Protein Overview: HIS2

General Information:
Name(s) found:	HIS2 / YFR025C [SGD]
Description(s) found: SHOW ONLY BEST	gi\|836780\|dbj\|BAA09264.1\| histidinol phosphatase [Saccharomyces cerevisiae] [NCBI NR] gi\|14318548\|ref\|NP_116681.1\| Histidinolphosphatase, catalyzes the eighth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control; His2p [Sacchar [NCBI NR] pir\|\|S56280 histidinol-phosphatase (EC 3.1.3.15) - yeast (Saccharomyces cerevisiae) [NCBI NR] HIS2 Histidinol phosphatase [mips] Histidinolphosphatase, catalyzes the eighth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control [SGD] HIS2, Chr VI from 203730-204737, reverse complement [yeast_orfs2] Chr VI from 203730-204737, reverse complement [yeastorf3.fasta] Chr VI from 204738-203731, reverse complement [yeastorf5.fasta] HIS2 SGDID:S0001921, Chr VI from 204738-203731, reverse complement, Verified ORF [yeastflysequest.fasta] His2p [Saccharomyces cerevisiae]gi\|1084555\|pir\|\|S56280 histidinol-phosphatase (EC 3.1.3.15) - yeast (Saccharomyces cerevisiae)gi\|836780\|dbj\|BAA09264.1\| histidinol phosphatase [Saccharomyces cerevisiae] [nrdb_11152004_Chlamydomonas] HIS2 SGDID:S000001921, Chr VI from 204738-203731, reverse complement, Verified ORF, "Histidinolphosphatase, catalyzes the eighth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] histidinol phosphatase [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Histidinolphosphatase, catalyzes the eighth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control; His2p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] HIS2 SGDID:S000001921, Chr VI from 204738-203731, reverse complement, Verified ORF, "Histidinolphosphatase, catalyzes the eighth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control" [yeast-bovrabprots.fasta] [chemostatdb.fasta] Histidinol-phosphatase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HIS2 PE=1 SV=2 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] HIS2 SGDID:S000001921, Chr VI from 204750-203743, Genome Release 64-1-1, reverse complement, Verified ORF, "Histidinolphosphatase, catalyzes the eighth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control" [yeast-030211-contam.fasta] HIS2 SGDID:S000001921, Chr VI from 204750-203743, Genome Release 64-2-1, reverse complement, Verified ORF, "Histidinolphosphatase; catalyzes the eighth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control" [20141208_orf_trans.fasta] YFR025C SGDID:S000001921, Chr VI from 204750-203743, Genome Release 64-1-1, reverse complement, Verified ORF, "Histidinolphosphatase, catalyzes the eighth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
Organism:	Saccharomyces cerevisiae
Length:	335 amino acids
Gene Ontology:
Cellular Component:	intracellular [TAS]
Biological Process:	histidine biosynthetic process [TAS]
Molecular Function:	histidinol-phosphatase activity [TAS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MHSHHSHSGD YSAHGTDPLD SVVDQVVNLN FHTYCLTEHI PRIEAKFIYP EEQSLGKNPE  60
   61 EVITKLETSF KNFMSHAQEI KTRYADRPDV RTKFIIGMEI ESCDMAHIEY AKRLMKENND 120
  121 ILKFCVGSVH HVNGIPIDFD QQQWYNSLHS FNDNLKHFLL SYFQSQYEML INIKPLVVGH 180
  181 FDLYKLFLPN DMLVNQKSGN CNEETGVPVA SLDVISEWPE IYDAVVRNLQ FIDSYGGAIE 240
  241 INTSALRKRL EEPYPSKTLC NLVKKHCGSR FVLSDDAHGV AQVGVCYDKV KKYIVDVLQL 300
  301 EYICYLEESQ SPENLLTVKR LPISQFVNDP FWANI

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Krogan NJ, et al. (2006)		BRN1 HIS2 SMC2 SMC4 YCG1 YCS4

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	MLP2	#12 Mitotic Prep1-TiO2 Flowthrough	Keck JM, et al. (2011)
View Run	MLP2	#11 Mitotic Prep1-TiO2 enriched, new search criteria	Keck JM, et al. (2011)

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

	PROTEIN(S)	PUBLICATION
View Data	HIS2	Huh WK, et al. (2003)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..88]	deduced	N/A	No confident structure predictions are available.
2	View Details	[89..335]	Pfam	11.958607	PHP domain No confident structure predictions are available.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Protein Overview: HIS2

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: