YRC Public Data Repository - Protein Structure Prediction

Protein:	HIS2
Organism:	Saccharomyces cerevisiae
Length:	335 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HIS2.

Description	E-value	Query Range	Subject Range
HIS9_YEAST - Histidinol-phosphatase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HIS2 PE=1 SV=2 HIS2 - Histidinolphosphatase, catalyzes the eighth step in histidine biosynthesis; mutations cause histidin... gi\|190406598 - gi\|190406598\|gb\|EDV09865.1\| histidinolphosphatase [Saccharomyces cerevisiae RM11-1a]	0.0	[1..335]	[1..335]
gi\|16413019, gi\|... - pir\|\|AC1505 histidinol phosphate phosphatase homolog hisJ - Listeria innocua (strain Clip11262), gi\|... gi\|16799654 - gi\|16799654\|ref\|NP_469922.1\| histidinol-phosphatase [Listeria innocua Clip11262]	1.0E-56	[3..288]	[4..270]
gi\|153173445, gi... - gi\|254828363\|ref\|ZP_05233050.1\| histidinol-phosphatase [Listeria monocytogenes FSL N3-165], gi\|15317... gi\|16409946, gi\|... - pir\|\|AC1146 histidinol phosphate phosphatase homolog hisJ [imported] - Listeria monocytogenes (strai... gi\|16802613 - gi\|16802613\|ref\|NP_464098.1\| histidinol-phosphatase [Listeria monocytogenes EGD-e] gi\|224502129 - gi\|224502129\|ref\|ZP_03670436.1\| histidinol-phosphatase [Listeria monocytogenes FSL R2-561]	8.0E-56	[3..288]	[4..270]
gi\|221315232 - gi\|221315232\|ref\|ZP_03597037.1\| histidinol-phosphatase [Bacillus subtilis subsp. subtilis str. NCIB ... gi\|221320150 - gi\|221320150\|ref\|ZP_03601444.1\| histidinol-phosphatase [Bacillus subtilis subsp. subtilis str. JH642... gi\|221324431 - gi\|221324431\|ref\|ZP_03605725.1\| histidinol-phosphatase [Bacillus subtilis subsp. subtilis str. SMY] HIS9_BACSU - Histidinol-phosphatase OS=Bacillus subtilis GN=hisK PE=1 SV=1 HIS9_BACSU - Histidinol-phosphatase OS=Bacillus subtilis (strain 168) GN=hisK PE=1 SV=1	1.0E-51	[3..288]	[5..262]
HIS9_DEIRA - Probable histidinol-phosphatase OS=Deinococcus radiodurans GN=hisK PE=3 SV=1 HIS9_DEIRA - Probable histidinol-phosphatase OS=Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 1687...	2.0E-50	[3..297]	[6..246]
HIS9_BACHD - Histidinol-phosphatase OS=Bacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 915... HIS9_BACHD - Histidinol-phosphatase OS=Bacillus halodurans GN=hisK PE=3 SV=1	2.0E-49	[2..288]	[4..262]
gi\|18310038, gi\|... - gi\|18310038\|ref\|NP_561972.1\| histidinol-phosphatase [Clostridium perfringens str. 13], gi\|18144717\|d...	2.0E-49	[3..294]	[8..267]
HIS9_LACLA - Histidinol-phosphatase OS=Lactococcus lactis subsp. lactis GN=hisK PE=3 SV=2 HIS9_LACLA - Histidinol-phosphatase OS=Lactococcus lactis subsp. lactis (strain IL1403) GN=hisK PE=1 SV=2	3.0E-38	[3..294]	[5..244]

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Predicted Domain #1

Region A:
Residues: [1-88]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MHSHHSHSGD YSAHGTDPLD SVVDQVVNLN FHTYCLTEHI PRIEAKFIYP EEQSLGKNPE  60
   61 EVITKLETSF KNFMSHAQEI KTRYADRP

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [89-335]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DVRTKFIIGM EIESCDMAHI EYAKRLMKEN NDILKFCVGS VHHVNGIPID FDQQQWYNSL  60
   61 HSFNDNLKHF LLSYFQSQYE MLINIKPLVV GHFDLYKLFL PNDMLVNQKS GNCNEETGVP 120
  121 VASLDVISEW PEIYDAVVRN LQFIDSYGGA IEINTSALRK RLEEPYPSKT LCNLVKKHCG 180
  181 SRFVLSDDAH GVAQVGVCYD KVKKYIVDVL QLEYICYLEE SQSPENLLTV KRLPISQFVN 240
  241 DPFWANI

[Run NCBI BLAST on this sequence.]

Detection Method:	Pfam
Confidence:	11.958607
Match:	PF02811
Description:	PHP domain

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits