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Protein Overview: YRF1-2

General Information:
Name(s) found: YRF1-2 / YER190W [SGD]
Description(s) found:
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  • gi|971261|gb|AAB65037.1| Yer190wp [Saccharomyces cerevisiae] [NCBI NR]
  • gi|6321038|ref|NP_011117.1| Helicase encoded by the Y' element of subtelomeric regions, highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p; Yrf1-2p [Saccharomyces cerevisiae] [NCBI NR]
  • gi|2506763|sp|P40105.2|YRF12_YEAST RecName: Full=Y' element ATP-dependent helicase protein 1 copy 2 [NCBI NR]
  • pir||S59693 hypothetical protein YER190w - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • (P40105) Y'helicase protein 1 copy 2 [Swiss-Prot]
  • Y' element ATP-dependent helicase protein 1 copy 2 OS=Saccharomyces cerevisiae GN=YRF1-2 PE=2 SV=2 [Swiss-Prot]
  • YRF1-2 Y`-helicase protein 1 [mips]
  • Helicase encoded by the Y' element of subtelomeric regions, highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p; induced by treatment with 8-methoxypsoralen and UVA irradiation [SGD]
  • YRF1-2, Chr V from 571475-576520 [yeast_orfs2]
  • Chr V from 571475-576520 [yeastorf3.fasta]
  • YRF1-2 SGDID:S0000992, Chr V from 571475-576520, Verified ORF [yeastflysequest.fasta]
  • Helicase encoded by the Y' element of subtelomeric regions, highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p [Saccharomyces cerevisiae]gi|2506763|sp|P40105|YRF2_YEAST Y'helicase protein 1 copy 2 [nrdb_11152004_Chlamydomonas]
  • YRF1-2 SGDID:S000000992, Chr V from 571475-576520, Verified ORF, "Helicase encoded by the Y' element of subtelomeric regions, highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • YRF1-2 SGDID:S000000992, Chr V from 571475-576520, Verified ORF, "Helicase encoded by the Y' element of subtelomeric regions, highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p; induced by treatment [SGD_S-cerevisiae_na_08-19-2008_con_reversed.fasta]
  • Yer190wp [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Helicase encoded by the Y' element of subtelomeric regions, highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p; Yrf1-2p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Y'helicase protein 1 copy 2 [nr-271106-contam.fasta]
  • YRF1-2 SGDID:S000000992, Chr V from 571475-576520, Verified ORF, "Helicase encoded by the Y' element of subtelomeric regions, highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p; induced by treatment with 8-methoxypsoralen and UVA irradiation" [yeast-bovrabprots.fasta]
  • [chemostatdb.fasta]
  • Y' element ATP-dependent helicase protein 1 copy 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=YRF1-2 PE=2 SV=2 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • YRF1-2 SGDID:S000000992, Chr V from 571480-576525, Genome Release 64-1-1, Verified ORF, "Helicase encoded by the Y' element of subtelomeric regions, highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p; induced by treatment with 8-methoxypsoralen and UVA irradiation" [yeast-030211-contam.fasta]
  • YRF1-2 SGDID:S000000992, Chr V from 571480-576525, Genome Release 64-2-1, Verified ORF, "Helicase encoded by the Y' element of subtelomeric regions; highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p; induced by treatment with 8-methoxypsoralen and UVA irradiation" [20141208_orf_trans.fasta]
  • YER190W SGDID:S000000992, Chr V from 571480-576525, Genome Release 64-1-1, Verified ORF, "Helicase encoded by the Y' element of subtelomeric regions, highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p; induced by treatment with 8-methoxypsoralen and UVA irradiation" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 1681 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IC]
    Biological Process: telomere maintenance via recombination [IGILink to PubMed article]
    Molecular Function: DNA helicase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVYTLFQVHT LKFNRKDYDT LSLFYLNRGY YNELSFRVLE RCHEKASARP NDSSTMRTFT  60
   61 DFVSGAPIVR SLQKSTIRKY GYNLAPYMFL LLHVDELSIF SAYQASLPGE KKVDTERLKR 120
  121 DLCPRKPTEI KYFSQICNDM MNKKDRLGDI LHIILRACAL NFGAGPRGGA GDEEDRSITN 180
  181 EEPIIPSVDE HGLKVCKLRS PNTPRRLRKT LDAVKALLVS SCACTARDLD IFDDNNGVAM 240
  241 WKWIKILYHE VAQETALKDS YRITLVPSSD GVSVCGKLFN REYVRGFYFA CKAQFDNLWE 300
  301 ELNDCFYMPT VVDIASLILR NREVLFREPK RGIDEYLEND SFLQMIPVKY REIVLPKLRR 360
  361 DTNKMTAALK NKVTVAIDEL TVPLMWMIHF AVGYPYRYPE LQLLAFAGPQ RNVYVDDTTR 420
  421 RIQLYTDYNK NGSSEPRLKT LDGLTSDYVF YFVTVLRQMQ ICALGNSYDA FNHDPWMDVV 480
  481 GFEDPDQVTN RDISRIVLYS YMFLNTAKGC LVEYATFRQY MRELPKNAPQ KLNFREMRQG 540
  541 LIALGRHCVG SRFETDLYES ATSELMANHS VQTGRNIYGV DSFSLTSVSG TTATLLQERA 600
  601 SERWIQWLGL ESDYHCSFSS TRNAEDVVAG EAASSDHHQK ISRVTRKRPR EPKSTNDILV 660
  661 AGQKLFGSSF EFRDLHQLRL CHEIYMADTP SVAVQAPPGY GKTELFHLPL IALASKGDVK 720
  721 YVSFLFVPYT VLLANCMIRL SRCGCLNVAP VRNFIEEGCD GVTDLYVGIY DDLASTNFTD 780
  781 RIAAWENIVE CTFRTNNVKL GYLIVDEFHN FETEVYRQSQ FGGITNLDFD AFEKAIFLSG 840
  841 TAPEAVADAA LQRIGLTGLA KKSMDINELK RSEDLSRGLS SYPTRMFNLI KEKSEVPLGH 900
  901 VHKIWKKVES QPEEALKLLL ALFEIEPESK AIVVASTTNE VEELACSWRK YFRVVWIHGK 960
  961 LGAAEKVSRT KEFVTDGSMR VLIGTKLVTE GIDIKQLMMV IMLDNRLNII ELIQGVGRLR1020
 1021 DGGLCYLLSR KNSWAARNRK GELPPIKEGC ITEQVREFYG LESKKGKKGQ HVGCCGSRTD1080
 1081 LSADTVELIE RMDRLAEKQA TASMSIVALP SSFQESNSSD RCRKYCSSDE DSDTCIHGSA1140
 1141 NASTNATTNS STNATTTAST NVRTSATTTA SINVRTSATT TESTNSSTNA TTTASTNVRT1200
 1201 SATTTASINV RTSATTTEST NSNTSATTTE STDSNTSATT TESTDSNTSA TTTASTNSST1260
 1261 NATTTASTNS STNATTTEST NASAKEDANK DGNAEDNRFH PVTDINKESY KRKGSQMVLL1320
 1321 ERKKLKAQFP NTSENMNVLQ FLGFRSDEIK HLFLYGIDVY FCPEGVFTQY GLCKGCQKMF1380
 1381 ELCVCWAGQK VSYRRMAWEA LAVERMLRND EEYKEYLEDI EPYHGDPVGY LKYFSVKRGE1440
 1441 IYSQIQRNYA WYLAITRRRE TISVLDSTRG KQGSQVFRMS GRQIKELYYK VWSNLRESKT1500
 1501 EVLQYFLNWD EKKCREEWEA KDDTVFVEAL EKVGVFQRLR SMTSAGLQGP QYVKLQFSRH1560
 1561 HRQLRSRYEL SLGMHLRDQL ALGVTPSKVP HWTAFLSMLI GLFCNKTFRQ KLEYLLEQIS1620
 1621 EVWLLPHWLD LANVEVLAAD NTRVPLYMLM VAVHKELDSD DVPDGRFDIL LCRDSSREVG1680
 1681 E

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run RLF2 phosphorylation data - cascade search Green EM, et al (2005)
    View Run MLP2 #24 Asynchronous Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..63] MSA 1.011987 View MSA. No confident structure predictions are available.
    2 View Details [64..393] ORFEUS 7.14 Alpha subunit of glutamate synthase, C-terminal domain; Alpha subunit of glutamate synthase, central and FMN domains; Alpha subunit of glutamate synthase, N-terminal domain
    3 View Details [394..580] deduced N/A No confident structure predictions are available.
    4 View Details [581..1079] PSI-BLAST 164.9897 Initiation factor 4a
    5 View Details [1080..1335] ORFEUS 12.41 Sec24
    6 View Details [1336..1681] ORFEUS 7.11 Hemolysin E (HlyE, ClyA, SheA)
    7 View Details [1585..1681] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.82

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle