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Protein Overview: MXR1

General Information:
Name(s) found: MXR1 / YER042W [SGD]
Description(s) found:
Found 31 descriptions.
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  • Methionine-S-sulfoxide reductase, involved in the response to oxidative stress; protects iron-sulfur clusters from oxidative inactivation along with MXR2; involved in the regulation of lifespan [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 184 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    Biological Process: response to oxidative stress [IGILink to PubMed article][IMPLink to PubMed articleLink to PubMed article]
    Molecular Function: peptide-methionine-(S)-S-oxide reductase activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSLISKTIK YDPAKDKLIT LACGCFWGTE HMYRKYLNDR IVDCKVGYAN GEESKKDSPS  60
   61 SVSYKRVCGG DTDFAEVLQV SYNPKVITLR ELTDFFFRIH DPTTSNSQGP DKGTQYRSGL 120
  121 FAHSDADLKE LAKIKEEWQP KWGNKIATVI EPIKNFYDAE EYHQLYLDKN PQGYACPTHY 180
  181 LREM

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run MLP2 #24 Asynchronous Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data MXR1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..184] PSI-BLAST 294.0 Peptide methionine sulfoxide reductase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • oxidoreductase activity, acting on sulfur group of donors, disulfide as acceptor
    		•  7.33214277590189 bayes_pls_golite062009
  • peptide-methionine-(S)-S-oxide reductase activity
    		•  7.05871760837663 bayes_pls_golite062009
  • oxidoreductase activity, acting on sulfur group of donors
    		•  4.45221508174489 bayes_pls_golite062009
  • catalytic activity
    		•  2.02168745464921 bayes_pls_golite062009
  • binding
    		•  1.21670366786992 bayes_pls_golite062009
  • protein binding
    		•  0.0950083680136139 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle