YRC Public Data Repository - Protein Structure Prediction

Protein:	MXR1
Organism:	Saccharomyces cerevisiae
Length:	184 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MXR1.

Description	E-value	Query Range	Subject Range
MSRA_YEAST - Peptide methionine sulfoxide reductase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=M... gi\|151944752 - gi\|151944752\|gb\|EDN63011.1\| peptide methionine sulfoxide reductase [Saccharomyces cerevisiae YJM789] MXR1 - Methionine-S-sulfoxide reductase, involved in the response to oxidative stress; protects iron-sulfur... gi\|190405604 - gi\|190405604\|gb\|EDV08871.1\| peptide methionine sulfoxide reductase [Saccharomyces cerevisiae RM11-1a...	8.0E-73	[1..184]	[1..184]
gi\|14029838 - gi\|14029838\|gb\|AAK52833.1\| methionine sulfoxide reductase [Saccharomyces pastorianus]	8.0E-72	[1..184]	[1..184]
gi\|12832275 - gi\|12832275\|dbj\|BAB22035.1\| unnamed protein product [Mus musculus]	2.0E-65	[6..174]	[53..217]
MSRA_SHIFL - Peptide methionine sulfoxide reductase MsrA OS=Shigella flexneri GN=msrA PE=3 SV=2 MSRA_ECOLI - Peptide methionine sulfoxide reductase msrA (EC 1.8.4.11) (Protein-methionine-S-oxide reductase) (Pe... gi\|30043753, gi\|... - gi\|30065489\|ref\|NP_839660.1\| methionine sulfoxide reductase A [Shigella flexneri 2a str. 2457T], gi\|... EG11433 - methionine sulfoxide reductase A / Methionine sulfoxide reductase A; specific for S diastereoisomers MSRA_SHIF8 - Peptide methionine sulfoxide reductase MsrA OS=Shigella flexneri serotype 5b (strain 8401) GN=msrA P... MSRA_SHISS - Peptide methionine sulfoxide reductase MsrA OS=Shigella sonnei (strain Ss046) GN=msrA PE=3 SV=1 MSRA_ECOHS - Peptide methionine sulfoxide reductase MsrA OS=Escherichia coli O9:H4 (strain HS) GN=msrA PE=3 SV=1 EG11433 - methionine sulfoxide reductase A / Methionine sulfoxide reductase A; specific for S diastereoisomers MSRA_ECO24 - Peptide methionine sulfoxide reductase MsrA OS=Escherichia coli O139:H28 (strain E24377A / ETEC) GN=... gi\|188487558, gi... - gi\|188492359\|ref\|ZP_02999629.1\| methionine-S-sulfoxide reductase [Escherichia coli 53638], gi\|188487... MSRA_ECODH - Peptide methionine sulfoxide reductase MsrA OS=Escherichia coli (strain K12 / DH10B) GN=msrA PE=3 SV... gi\|89110939, gi\|... - gi\|89110939\|ref\|AP_004719.1\| methionine sulfoxide reductase A [Escherichia coli str. K-12 substr. W3... gi\|56480565, gi\|... - gi\|56480565\|ref\|NP_709979.2\| methionine sulfoxide reductase A [Shigella flexneri 2a str. 301], gi\|56... MSRA_ECO55 - Peptide methionine sulfoxide reductase MsrA OS=Escherichia coli (strain 55989 / EAEC) GN=msrA PE=3 S... gi\|251787472, gi... - gi\|251787472\|ref\|YP_003001776.1\| hypothetical protein B21_04053 [Escherichia coli BL21], gi\|24237974... MSRA_ECOLC - Peptide methionine sulfoxide reductase MsrA OS=Escherichia coli (strain ATCC 8739 / DSM 1576 / Crook... MSRA_ECOBW - Peptide methionine sulfoxide reductase MsrA OS=Escherichia coli (strain K12 / MC4100 / BW2952) GN=ms... gi\|194426648, gi... - gi\|194426648\|ref\|ZP_03059202.1\| methionine-S-sulfoxide reductase [Escherichia coli B171], gi\|1944153... gi\|253976053, gi... - gi\|254164152\|ref\|YP_003047260.1\| methionine sulfoxide reductase A [Escherichia coli B str. REL606], ... gi\|193069821, gi... - gi\|193069821\|ref\|ZP_03050771.1\| methionine-S-sulfoxide reductase [Escherichia coli E110019], gi\|1929... gi\|253775152, gi... - gi\|254290902\|ref\|YP_003056650.1\| methionine sulfoxide reductase A [Escherichia coli BL21(DE3)], gi\|2... gi\|193063624, gi... - gi\|193063624\|ref\|ZP_03044712.1\| methionine-S-sulfoxide reductase [Escherichia coli E22], gi\|19293061... gi\|191167258, gi... - gi\|191167258\|ref\|ZP_03029076.1\| methionine-S-sulfoxide reductase [Escherichia coli B7A], gi\|19090271... MSRA_ECO45 - Peptide methionine sulfoxide reductase MsrA OS=Escherichia coli O45:K1 (strain S88 / ExPEC) GN=msrA ... MSRA_ECO8A - Peptide methionine sulfoxide reductase MsrA OS=Escherichia coli O8 (strain IAI1) GN=msrA PE=3 SV=1 gi\|194437804, gi... - gi\|194437804\|ref\|ZP_03069899.1\| methionine-S-sulfoxide reductase [Escherichia coli 101-1], gi\|194423... gi\|194417846, gi... - gi\|194433865\|ref\|ZP_03066138.1\| methionine-S-sulfoxide reductase [Shigella dysenteriae 1012], gi\|194... gi\|124528285, gi... - gi\|124528285\|ref\|ZP_01699609.1\| peptide methionine sulfoxide reductase [Escherichia coli B], gi\|1245...	2.0E-65	[8..171]	[35..195]
MSRA - methionine sulfoxide reductase A	5.0E-65	[6..174]	[55..219]
MSRA4_ARATH - Peptide methionine sulfoxide reductase A4, chloroplastic OS=Arabidopsis thaliana GN=MSR4 PE=1 SV=2	6.0E-65	[3..169]	[77..236]
MSRA_RAT - Mitochondrial peptide methionine sulfoxide reductase OS=Rattus norvegicus GN=Msra PE=1 SV=1	7.0E-65	[6..174]	[53..217]
MSRA_BRANA - Peptide methionine sulfoxide reductase OS=Brassica napus GN=PMSR PE=2 SV=1	8.0E-65	[2..169]	[75..235]
MSRA_SALTY - Peptide methionine sulfoxide reductase msrA OS=Salmonella typhimurium GN=msrA PE=3 SV=1 MSRA_SALTY - Peptide methionine sulfoxide reductase MsrA OS=Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC ... gi\|167991183, gi... - gi\|205330272\|gb\|EDZ17036.1\| peptide-methionine (S)-S-oxide reductase [Salmonella enterica subsp. ent... gi\|197264861, gi... - gi\|197264861\|ref\|ZP_03164935.1\| peptide-methionine (S)-S-oxide reductase [Salmonella enterica subsp.... MSRA_SALTY - Peptide methionine sulfoxide reductase MsrA OS=Salmonella typhimurium GN=msrA PE=3 SV=1 MSRA_SALNS - Peptide methionine sulfoxide reductase MsrA OS=Salmonella newport (strain SL254) GN=msrA PE=3 SV=1 gi\|195632867, gi... - gi\|195632867\|gb\|EDX51321.1\| peptide-methionine (S)-S-oxide reductase [Salmonella enterica subsp. ent... gi\|205348662, gi... - gi\|205348662\|gb\|EDZ35293.1\| peptide-methionine (S)-S-oxide reductase [Salmonella enterica subsp. ent... lcl\|NC_016856.1_... - [gene=msrA] [protein=methionine sulfoxide reductase A] [protein_id=YP_005240725.1] [location=complem...	1.0E-64	[8..171]	[35..195]

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Predicted Domain #1

Region A:
Residues: [1-184]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSLISKTIK YDPAKDKLIT LACGCFWGTE HMYRKYLNDR IVDCKVGYAN GEESKKDSPS  60
   61 SVSYKRVCGG DTDFAEVLQV SYNPKVITLR ELTDFFFRIH DPTTSNSQGP DKGTQYRSGL 120
  121 FAHSDADLKE LAKIKEEWQP KWGNKIATVI EPIKNFYDAE EYHQLYLDKN PQGYACPTHY 180
  181 LREM

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	294.0
Match:	1fvaA_
Description:	Peptide methionine sulfoxide reductase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
oxidoreductase activity, acting on sulfur group of donors, disulfide as acceptor	7.33214277590189	bayes_pls_golite062009
peptide-methionine-(S)-S-oxide reductase activity	7.05871760837663	bayes_pls_golite062009
oxidoreductase activity, acting on sulfur group of donors	4.45221508174489	bayes_pls_golite062009
catalytic activity	2.02168745464921	bayes_pls_golite062009
binding	1.21670366786992	bayes_pls_golite062009
protein binding	0.0950083680136139	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: