Protein Overview: KRE29

General Information:
Name(s) found:	KRE29 / YER038C [SGD]
Description(s) found: SHOW ONLY BEST	gi\|731455\|sp\|P40026.1\|KRE29_YEAST RecName: Full=DNA repair protein KRE29; AltName: Full=Killer toxin-resistance protein 29 [NCBI NR] gi\|6320876\|ref\|NP_010955.1\| Essential subunit of the Mms21-Smc5-Smc6 complex; protein of unknown function; required for growth and DNA repair; heterozygous mutant shows haploinsufficiency in K1 killer toxin resistance; Kre29p [Saccharomyces cerevisiae] [NCBI NR] gi\|603271\|gb\|AAB64573.1\| Yer038cp [Saccharomyces cerevisiae] [NCBI NR] pir\|\|S50541 hypothetical protein YER038c - yeast (Saccharomyces cerevisiae) [NCBI NR] (P40026) Hypothetical 53.8 kDa protein in PIP1-GLN3 intergenic region [Swiss-Prot] DNA repair protein KRE29 OS=Saccharomyces cerevisiae GN=KRE29 PE=1 SV=1 [Swiss-Prot] KRE29 Killer toxin REsistant protein [mips] Essential subunit of the Mms21-Smc5-Smc6 complex, required for growth and DNA repair; heterozygous mutant shows haploinsufficiency in K1 killer toxin resistance [SGD] KRE29, Chr V from 226857-228251, reverse complement [yeast_orfs2] Chr V from 226857-228251, reverse complement [yeastorf3.fasta] Chr V from 228251-226857, reverse complement [yeastorf5.fasta] KRE29 SGDID:S0000840, Chr V from 228251-226857, reverse complement, Verified ORF [yeastflysequest.fasta] Essential protein of unknown function; heterozygous mutant shows haploinsufficiency in K1 killer toxin resistance [Saccharomyces cerevisiae]gi\|731455\|sp\|P40026\|YEM8_YEAST Hypothetical 53.8 kDa protein in PIP1-GLN3 intergenic regiongi\|1077648\|pir\|\|S50541 [nrdb_11152004_Chlamydomonas] KRE29 SGDID:S000000840, Chr V from 228251-226857, reverse complement, Verified ORF, "Essential protein of unknown function; heterozygous mutant shows haploinsufficiency in K1 killer toxin resistance" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] KRE29 SGDID:S000000840, Chr V from 228251-226857, reverse complement, Verified ORF, "Essential subunit of the Mms21-Smc5-Smc6 complex; protein of unknown function; required for growth and DNA repair; heterozygous mutant shows haploinsufficiency in K1 kill [yeast-contam.fasta] KRE29 SGDID:S000000840, Chr V from 228251-226857, reverse complement, Verified ORF, "Essential subunit of the Mms21-Smc5-Smc6 complex, required for growth and DNA repair; heterozygous mutant shows haploinsufficiency in K1 killer toxin resistance" [yeast-200209-contam.fasta] DNA repair protein KRE29 (Killer toxin-resistance protein 29) [nr-271106-contam.fasta] Essential subunit of the Mms21-Smc5-Smc6 complex; protein of unknown function; required for growth and DNA repair; heterozygous mutant shows haploinsufficiency in K1 killer toxin resistance; Kre29p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Yer038cp [Saccharomyces cerevisiae] [nr-271106-contam.fasta] KRE29 SGDID:S000000840, Chr V from 228251-226857, reverse complement, Verified ORF, "Essential subunit of the Mms21-Smc5-Smc6 complex; protein of unknown function; required for growth and DNA repair; heterozygous mutant shows haploinsufficiency in K1 killer toxin resistance" [yeast-contam_custom.fasta] [chemostatdb.fasta] DNA repair protein KRE29 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=KRE29 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] KRE29 SGDID:S000000840, Chr V from 228252-226858, Genome Release 64-1-1, reverse complement, Verified ORF, "Essential subunit of the Mms21-Smc5-Smc6 complex, required for growth and DNA repair; heterozygous mutant shows haploinsufficiency in K1 killer toxin resistance" [yeast-030211-contam.fasta] KRE29 SGDID:S000000840, Chr V from 228252-226858, Genome Release 64-2-1, reverse complement, Verified ORF, "Subunit of the SMC5-SMC6 complex; this complex is involved in removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; heterozygous mutant shows haploinsufficiency in K1 killer toxin resistance" [20141208_orf_trans.fasta] YER038C SGDID:S000000840, Chr V from 228252-226858, Genome Release 64-1-1, reverse complement, Verified ORF, "Essential subunit of the Mms21-Smc5-Smc6 complex, required for growth and DNA repair; heterozygous mutant shows haploinsufficiency in K1 killer toxin resistance" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
Organism:	Saccharomyces cerevisiae
Length:	464 amino acids
Gene Ontology:
Cellular Component:	nucleus [IDA] cytoplasm [IDA] Smc5-Smc6 complex [IPI]
Biological Process:	DNA repair [IMP]
Molecular Function:	molecular_function [ND]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGSVNSSPNE EFETVPDSQI SGFDSPLIPT SVGSYFRDDD DDEKVHPNFI SDPENDSLNS  60
   61 DEEFSSLENS DLNLSGAKAE SGDDFDPILK RTIISKRKAP SNNEDEEIVK TPRKLVNYVP 120
  121 LKIFNLGDSF DDTITTTVAK LQDLKKEILD SPRSNKSIVI TSNTVAKSEL QKSIKFSGSI 180
  181 PEIYLDVVTK ETISDKYKDW HFISKNCHYE QLMDLEMKDT AYSFLFGSSR SQGKVPEFVH 240
  241 LKCPSITNLL VLFGVNQEKC NSLKINYEKK ENSRYDNLCT IFPVNKMLKF LMYFYSDDDN 300
  301 DDVREFFLKA FICLILDRKV FNAMESDHRL CFKVLELFNE AHFINSYFEI VDKNDFFLHY 360
  361 RLLQIFPHLQ SALLRRRFSE KQGRTETIQQ NIIKEFNEFF DCKNYKNLLY FILTMYGSKF 420
  421 IPFGPKCQVT EYFKDCILDI SNETTNDVEI SILKGILNLF SKIR

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Hazbun TR, et al. (2003)		KRE29 MMS21 NSE4 NSE5 SMC5 SMC6
View Details	Qiu et al. (2008)		KRE29 NSE3 NSE5

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	NSE5	No Comments	Hazbun TR, et al. (2003)
View Run	SMC5	No Comments	Hazbun TR, et al. (2003)
View Run	NSE5	No Comments	Hazbun TR, et al. (2003)
View Run	SMC5	No Comments	Hazbun TR, et al. (2003)
View Run	NSE5	No Comments	Hazbun TR, et al. (2003)
View Run	ZDS1	Sample 3 - cpn + atp, from june 2005	McCusker D, et al (2007)

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	NSE5	KRE29	2	Hazbun TR, et al. (2003)
View Screen	THO1	KRE29	1	Unpublished Fields Lab Data
View Screen	LSM8	KRE29	1	Unpublished Fields Lab Data
View Screen	SPT21	KRE29	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	KRE29	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..464]	deduced	N/A	No confident structure predictions are available.
2	View Details	[234..464]	deduced	N/A	No confident structure predictions are available.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2