Protein Overview: PHM8

General Information:
Name(s) found:	PHM8 / YER037W [SGD]
Description(s) found: SHOW ONLY BEST	gi\|731454\|sp\|P40025.1\|PHM8_YEAST RecName: Full=Phosphate metabolism protein 8 [NCBI NR] gi\|6320875\|ref\|NP_010954.1\| Protein of unknown function, expression is induced by low phosphate levels and by inactivation of Pho85p; Phm8p [Saccharomyces cerevisiae] [NCBI NR] gi\|603270\|gb\|AAB64572.1\| Yer037wp [Saccharomyces cerevisiae] [NCBI NR] pir\|\|S50540 hypothetical protein YER037w - yeast (Saccharomyces cerevisiae) [NCBI NR] (P40025) Hypothetical 37.7 kDa protein in PIP1-GLN3 intergenic region [Swiss-Prot] Phosphate metabolism protein 8 OS=Saccharomyces cerevisiae GN=PHM8 PE=1 SV=1 [Swiss-Prot] PHM8 Protein of unknown function, expression is induced by low phosphate levels and by inactivation of Pho85p [mips] Protein of unknown function, expression is induced by low phosphate levels and by inactivation of Pho85p [SGD] PHM8, Chr V from 225888-226853 [yeast_orfs2] Chr V from 225888-226853 [yeastorf3.fasta] PHM8 SGDID:S0000839, Chr V from 225888-226853, Verified ORF [yeastflysequest.fasta] Phm8p [Saccharomyces cerevisiae]gi\|731454\|sp\|P40025\|YEM7_YEAST Hypothetical 37.7 kDa protein in PIP1-GLN3 intergenic regiongi\|603270\|gb\|AAB64572.1\| Yer037wp [Saccharomyces cerevisiae]gi\|1077647\|pir\|\|S50540 hypothetical protein YER037w - yeast (Saccharo [nrdb_11152004_Chlamydomonas] PHM8 SGDID:S000000839, Chr V from 225888-226853, Verified ORF, "Protein of unknown function, expression is induced by low phosphate levels and by inactivation of Pho85p" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] Phosphate metabolism protein 8 [nr-271106-contam.fasta] Yer037wp [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Protein of unknown function, expression is induced by low phosphate levels and by inactivation of Pho85p; Phm8p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] [chemostatdb.fasta] Phosphate metabolism protein 8 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PHM8 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] PHM8 SGDID:S000000839, Chr V from 225889-226854, Genome Release 64-1-1, Verified ORF, "Lysophosphatidic acid (LPA) phosphatase involved in LPA hydrolysis in response to phosphate starvation; phosphatase activity is soluble and Mg2+ dependent; expression is induced by low phosphate levels and by inactivation of Pho85p" [yeast-030211-contam.fasta] PHM8 SGDID:S000000839, Chr V from 225889-226854, Genome Release 64-2-1, Verified ORF, "Lysophosphatidic acid (LPA) phosphatase, nucleotidase; principle and physiological nucleotidase working on GMP, UMP and CMP; involved in LPA hydrolysis in response to phosphate starvation and ribose salvage pathway; phosphatase activity is soluble and Mg2+ dependent; expression is induced by low phosphate levels and by inactivation of Pho85p; PHM8 has a paralog, SDT1, that arose from the whole genome duplication" [20141208_orf_trans.fasta] TR4981\|c0_g1_i1\|g.3321 ORF TR4981\|c0_g1_i1\|g.3321 TR4981\|c0_g1_i1\|m.3321 type:complete len:322 (+) TR4981\|c0_g1_i1:84-1049(+) [DBVPG6044_S_cerevisiae-Sep2015-contam.fasta] YER037W SGDID:S000000839, Chr V from 225889-226854, Genome Release 64-1-1, Verified ORF, "Lysophosphatidic acid (LPA) phosphatase involved in LPA hydrolysis in response to phosphate starvation; phosphatase activity is soluble and Mg2+ dependent; expression is induced by low phosphate levels and by inactivation of Pho85p" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta] asmbl_7542\|g.5557 ORF asmbl_7542\|g.5557 asmbl_7542\|m.5557 type:complete len:322 (+) asmbl_7542:82-1047(+) [DBVPG6044_Trinity_v2_2_0_PASA_6May2016-contam.fasta] ID=asmbl_7520\|g.4720 ORF ID=asmbl_7520\|g.4720 ID=asmbl_7520\|m.4720 type:complete len:322 (+) ID=asmbl_7520:82-1047(+) [DBVPG6044_quiverGenomes_Trinity_v2_2_0_PASA_2June2016-contam.fasta]
Organism:	Saccharomyces cerevisiae
Length:	321 amino acids
Gene Ontology:
Cellular Component:	nucleus [IDA] cytoplasm [IDA]
Biological Process:	biological_process [ND]
Molecular Function:	molecular_function [ND]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTIAKDYRTI YRNQIKKQIR LNQEHLQSLT HLGSQINFEV DPPKLPDPDP ARKVFFFDID  60
   61 NTLYRKSTKV QLLMQQSLSN FFKYELGFDD DEAERLIESY YQEYGLSVKG LIKNKQIDDV 120
  121 LQYNTFIDDS LPLQDYLKPD WKLRELLINL KKKKLGKFDK LWLFTNSYKN HAIRCVKILG 180
  181 IADLFDGITY CHYDRPIEEE FICKPDPKFF ETAKLQSGLS SFANAWFIDD NESNVRSALS 240
  241 MGMGHVIHLI EDYQYESENI VTKDHKNKQQ FSILKDILEI PLIMDVEVYR PSSIAIKEME 300
  301 ELEEEGEAVN WSNQQINVQS S

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	RPA135	No Comments	Schneider, DA, et al. (2006)

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	HMT1	PHM8	1	Unpublished Fields Lab Data
View Screen	LOS1	PHM8	1	Unpublished Fields Lab Data
View Screen	UBC7	PHM8	1	Unpublished Fields Lab Data
View Screen	CTF13	PHM8	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	PHM8	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..72] [130..321]	PSI-BLAST	27.39794	Phosphonoacetaldehyde hydrolase
2	View Details	[73..129]	PSI-BLAST	27.39794	Phosphonoacetaldehyde hydrolase

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2