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Protein Overview: MIG3

General Information:
Name(s) found: MIG3 / YER028C [SGD]
Description(s) found:
Found 24 descriptions.
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  • Probable transcriptional repressor involved in response to toxic agents such as hydroxyurea that inhibit ribonucleotide reductase; phosphorylation by Snf1p or the Mec1p pathway inactivates Mig3p, allowing induction of damage response genes [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 394 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    Biological Process: negative regulation of transcription from RNA polymerase II promoter [IGILink to PubMed article]
    transcription initiation [TASLink to PubMed article]
    response to DNA damage stimulus [IGILink to PubMed article]
    Molecular Function: DNA binding [IDALink to PubMed article]
    sequence-specific DNA binding [IDALink to PubMed article]
    specific transcriptional repressor activity [IDALink to PubMed article][IGILink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNYLRDRFPP DNDQRPFRCE ICSRGFHRLE HKKRHGRTHT GEKPHKCTVQ GCPKSFSRSD  60
   61 ELKRHLRTHT KGVQRRRIKS KGSRKTVVNT ATAAPTTFNE NTGVSLTGIG QSKVPPILIS 120
  121 VAQNCDDVNI RNTGNNNGIV ETQAPAILVP VINIPNDPHP IPSSLSTTSI TSIASVYPST 180
  181 SPFQYLKSGF PEDPASTPYV HSSGSSLALG ELSSNSSIFS KSRRNLAAMS GPDSLSSSKN 240
  241 QSSASLLSQT SHPSKSFSRP PTDLSPLRRI MPSVNTGDME ISRTVSVSSS SSSLTSVTYD 300
  301 DTAAKDMGMG IFFDRPPVTQ KACRSNHKYK VNAVSRGRQH ERAQFHISGD DEDSNVHRQE 360
  361 SRASNTSPNV SLPPIKSILR QIDNFNSAPS YFSK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #31 Asynchronous Prep (Protease cleavage) Keck JM, et al. (2011)
    View Run MLP2 #03 Alpha Factor Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data MIG3 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..110] PSI-BLAST 130.522879 No description for 1lu6A_ was found.
    2 View Details [111..179] PSI-BLAST 5.0 Enhancer binding protein
    3 View Details [180..291] MSA 3.104994 View MSA. No confident structure predictions are available.
    4 View Details [292..394] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle