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Protein Overview: HEM14

General Information:
Name(s) found: HEM14 / YER014W [SGD]
Description(s) found:
Found 25 descriptions.
SHOW ALL
  • Protoporphyrinogen oxidase, a mitochondrial enzyme that catalyzes the seventh step in the heme biosynthetic pathway, converting protoporphyrinogen IX to protoporphyrin IX; inhibited by diphenyl ether-type herbicides [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 539 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [IDALink to PubMed articleLink to PubMed article][ISSLink to PubMed article]
    Biological Process: heme biosynthetic process [IMPLink to PubMed article]
    Molecular Function: oxygen-dependent protoporphyrinogen oxidase activity [IMPLink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLLPLTKLKP RAKVAVVGGG VSGLCFTYFL SKLRPDVEIT LFESQNRTGG WIYSCNTRDM  60
   61 SGNPIMLEKG PRTLRGVSDG TVLIMDTLKD LGKEAVIQSI DKGCIADKKF LLDPSDKLVQ 120
  121 VPNSISTTVK FLLNPLGKGL ITGMMGEWFR KKSPHPGQDE SVESICDRRF GNNYISNNMI 180
  181 SALLRGIYGD DVSLLSAKRT FKKIYYNELK HGSNTQAMID NMRGKSRSKK TENLHQSLTG 240
  241 CLNDYSNAFG KDRSKLLDLS NTLKKYPMLG LAGGLETFPK IVRNALNEFK NVKIVTGNPV 300
  301 TQIMKRPANE TTIGLKAKSG DQYETFDHLR LTITPPKIAK LLPKDQNSLS KLLDEIQSNT 360
  361 IILVNYYLPN KDVIDADLQG FGYLVPKSNK NPGKLLGVIF DSVIERNFKP LFDKLSTNPN 420
  421 ALNKYTKVTA MIGGCMLNEH GVPVVPSREV TINAVKDALN NHLGISNKDL EAGQWEFTIA 480
  481 DRCLPRFHVG YDAWQERAER KLQESYGQTV SVGGMGFSRS PGVPDVIVDG FNDALQLSK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #14 Mitotic Prep2-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #11 Mitotic Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data HEM14 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..539] PSI-BLAST 59.30103 No description for 1h8qA_ was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • oxidoreductase activity, acting on NADH or NADPH
    		•  5.26950448055146 bayes_pls_golite062009
  • oxidoreductase activity
    		•  2.2944515778721 bayes_pls_golite062009
  • oxygen-dependent protoporphyrinogen oxidase activity
    		•  1.3578742399915 bayes_pls_golite062009
  • binding
    		•  1.26657667590853 bayes_pls_golite062009
  • oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor
    		•  1.20561532241252 bayes_pls_golite062009
  • oxidoreductase activity, acting on sulfur group of donors
    		•  1.07656675953489 bayes_pls_golite062009
  • catalytic activity
    		•  1.03127962968326 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-NH group of donors
    		•  0.945028138297487 bayes_pls_golite062009
  • transporter activity
    		•  0.890824576391732 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.706117386114413 bayes_pls_golite062009
  • hydrogen ion transmembrane transporter activity
    		•  0.705416796630992 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-NH2 group of donors
    		•  0.575252508985992 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.491481205015383 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.386071802386842 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.284200164472054 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.26114823844682 bayes_pls_golite062009
  • DNA binding
    		•  0.175069486065946 bayes_pls_golite062009
  • protein binding
    		•  0.0281459437915129 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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    Created and Maintained by: Michael Riffle