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View Structure Prediction Details

Protein: HEM14
Organism: Saccharomyces cerevisiae
Length: 539 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HEM14.

Description E-value Query
Range
Subject
Range
PPOX_YEAST - Protoporphyrinogen oxidase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HEM14 PE=1 SV...
HEM14 - Protoporphyrinogen oxidase, a mitochondrial enzyme that catalyzes the seventh step in the heme biosy...
1.0E-70 [1..539] [1..539]
gi|6715441, gi|1... - gi|6715441|gb|AAF26417.1|AF218052_1 protoporphyrinogen IX oxidase [Zea mays], gi|162458869|ref|NP_00...
4.0E-69 [2..537] [44..525]
PPOC_ORYSJ - Protoporphyrinogen oxidase, chloroplastic OS=Oryza sativa subsp. japonica GN=PPOX1 PE=2 SV=1
1.0E-68 [5..537] [49..526]
gi|8648059 - gi|8648059|dbj|BAA96808.1| protoporphyrinogen oxidase (Protox-I) [Spinacia oleracea]
1.0E-67 [13..538] [83..553]
gi|13991882 - gi|13991882|gb|AAK51545.1| phytoene desaturase [Citrus x paradisi]
2.0E-67 [6..539] [75..533]
gi|14423414 - gi|14423414|gb|AAK62389.1|AF386944_1 Unknown protein [Arabidopsis thaliana]
3.0E-67 [8..537] [53..527]
gi|193795408, gi... - gi|193795408|gb|ACF21784.1| phytoene desaturase [Gentiana lutea], gi|18146805|dbj|BAB82461.1| phytoe...
6.0E-67 [6..539] [102..560]
CRTI_NARPS - Phytoene dehydrogenase, chloroplastic/chromoplastic OS=Narcissus pseudonarcissus GN=PDS1 PE=1 SV=1
7.0E-67 [6..539] [92..550]
gi|4586308 - gi|4586308|dbj|BAA76348.1| protoporphyrinogen IX oxidase [Glycine max]
2.0E-66 [8..537] [10..487]

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Predicted Domain #1
Region A:
Residues: [1-539]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLLPLTKLKP RAKVAVVGGG VSGLCFTYFL SKLRPDVEIT LFESQNRTGG WIYSCNTRDM  60
   61 SGNPIMLEKG PRTLRGVSDG TVLIMDTLKD LGKEAVIQSI DKGCIADKKF LLDPSDKLVQ 120
  121 VPNSISTTVK FLLNPLGKGL ITGMMGEWFR KKSPHPGQDE SVESICDRRF GNNYISNNMI 180
  181 SALLRGIYGD DVSLLSAKRT FKKIYYNELK HGSNTQAMID NMRGKSRSKK TENLHQSLTG 240
  241 CLNDYSNAFG KDRSKLLDLS NTLKKYPMLG LAGGLETFPK IVRNALNEFK NVKIVTGNPV 300
  301 TQIMKRPANE TTIGLKAKSG DQYETFDHLR LTITPPKIAK LLPKDQNSLS KLLDEIQSNT 360
  361 IILVNYYLPN KDVIDADLQG FGYLVPKSNK NPGKLLGVIF DSVIERNFKP LFDKLSTNPN 420
  421 ALNKYTKVTA MIGGCMLNEH GVPVVPSREV TINAVKDALN NHLGISNKDL EAGQWEFTIA 480
  481 DRCLPRFHVG YDAWQERAER KLQESYGQTV SVGGMGFSRS PGVPDVIVDG FNDALQLSK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 59.30103
Match: 1h8qA_
Description: No description for 1h8qA_ was found.

Predicted functions:

Term Confidence Notes
oxidoreductase activity, acting on NADH or NADPH 5.26950448055146 bayes_pls_golite062009
oxidoreductase activity 2.2944515778721 bayes_pls_golite062009
oxygen-dependent protoporphyrinogen oxidase activity 1.3578742399915 bayes_pls_golite062009
binding 1.26657667590853 bayes_pls_golite062009
oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor 1.20561532241252 bayes_pls_golite062009
oxidoreductase activity, acting on sulfur group of donors 1.07656675953489 bayes_pls_golite062009
catalytic activity 1.03127962968326 bayes_pls_golite062009
oxidoreductase activity, acting on the CH-NH group of donors 0.945028138297487 bayes_pls_golite062009
transporter activity 0.890824576391732 bayes_pls_golite062009
transmembrane transporter activity 0.706117386114413 bayes_pls_golite062009
hydrogen ion transmembrane transporter activity 0.705416796630992 bayes_pls_golite062009
oxidoreductase activity, acting on the CH-NH2 group of donors 0.575252508985992 bayes_pls_golite062009
substrate-specific transporter activity 0.491481205015383 bayes_pls_golite062009
nucleic acid binding 0.386071802386842 bayes_pls_golite062009
transcription regulator activity 0.284200164472054 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.26114823844682 bayes_pls_golite062009
DNA binding 0.175069486065946 bayes_pls_golite062009
protein binding 0.0281459437915129 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle