Protein Overview: UGO1

General Information:
Name(s) found:	UGO1 / YDR470C [SGD]
Description(s) found: SHOW ONLY BEST	gi\|7839165\|ref\|NP_010758.2\| Protein of unknown function; outer membrane component of the mitochondrial fusion machinery; Ugo1p bind directly to Fzo1p and Mgm1p and thereby link these two GTPases during mitochondrial fusion; Ugo1p [Saccharomyces cerevisiae [NCBI NR] gi\|7654753\|gb\|AAB64924.2\| Ydr470cp; CAI: 0.15 [Saccharomyces cerevisiae] [NCBI NR] gi\|74583412\|sp\|Q03327.2\|UGO1_YEAST RecName: Full=Mitochondrial fusion and transport protein UGO1 [NCBI NR] Mitochondrial fusion and transport protein UGO1 OS=Saccharomyces cerevisiae GN=UGO1 PE=1 SV=2 [Swiss-Prot] UGO1 Outer membrane protein required for mitochondrial fusion [mips] Protein of unknown function; outer membrane component of the mitochondrial fusion machinery; Ugo1p bind directly to Fzo1p and Mgm1p and thereby link these two GTPases during mitochondrial fusion [SGD] UGO1, Chr IV from 1399695-1401203, reverse complement [yeast_orfs2] Chr IV from 1399695-1401203, reverse complement [yeastorf3.fasta] Chr IV from 1399694-1401202, reverse complement [yeastorf4.fasta] Chr IV from 1401202-1399694, reverse complement [yeastorf5.fasta] >Q03327 (Q03327) Ydr470cp [4932.FASTACCERV.txt] UGO1 SGDID:S0002878, Chr IV from 1401202-1399694, reverse complement, Verified ORF [yeastflysequest.fasta] UGO1 SGDID:S0002878, Chr IV from 1401204-1399696, reverse complement, Verified ORF [10112005cervSGD.fasta] Ydr470cp; CAI: 0.15 [Saccharomyces cerevisiae]gi\|7839165\|ref\|NP_010758.2\| Ugo1p [Saccharomyces cerevisiae] [nrdb_11152004_Chlamydomonas] (Q03327) Ydr470cp [cerv4932.FASTAC] UGO1 SGDID:S000002878, Chr IV from 1401204-1399696, reverse complement, Verified ORF, "Protein of unknown function; outer membrane component of the mitochondrial fusion machinery; Ugo1p bind directly to Fzo1p and Mgm1p and thereby link these two GTPases d [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] UGO1 SGDID:S000002878, Chr IV from 1401206-1399698, reverse complement, Verified ORF, "Protein of unknown function; outer membrane component of the mitochondrial fusion machinery; Ugo1p bind directly to Fzo1p and Mgm1p and thereby link these two GTPases d [yeast-contam.fasta] UGO1 SGDID:S000002878, Chr IV from 1401207-1399699, reverse complement, Verified ORF, "Protein of unknown function; outer membrane component of the mitochondrial fusion machinery; Ugo1p bind directly to Fzo1p and Mgm1p and thereby link these two GTPases d [SGD_S-cerevisiae_na_08-19-2008_con_reversed.fasta] Ydr470cp; CAI: 0.15 [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Protein of unknown function; outer membrane component of the mitochondrial fusion machinery; Ugo1p bind directly to Fzo1p and Mgm1p and thereby link these two GTPases during mitochondrial fusion; Ugo1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] UGO1 SGDID:S000002878, Chr IV from 1401207-1399699, reverse complement, Verified ORF, "Protein of unknown function; outer membrane component of the mitochondrial fusion machinery; Ugo1p bind directly to Fzo1p and Mgm1p and thereby link these two GTPases during mitochondrial fusion" [yeast-bovrabprots.fasta] UGO1 SGDID:S000002878, Chr IV from 1401206-1399698, reverse complement, Verified ORF, "Protein of unknown function; outer membrane component of the mitochondrial fusion machinery; Ugo1p bind directly to Fzo1p and Mgm1p and thereby link these two GTPases during mitochondrial fusion" [yeast-contam_custom.fasta] [chemostatdb.fasta]
Organism:	Saccharomyces cerevisiae
Length:	502 amino acids
Gene Ontology:
Cellular Component:	mitochondrion [IDA] mitochondrial outer membrane [IDA ]
Biological Process:	filamentous growth [IMP] mitochondrial fusion [IGI][IMP ][IPI] transport [ISS] mitochondrial genome maintenance [IMP]
Molecular Function:	transporter activity [ISS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNNNNVTEAT SRAQIRPYYD PDSFNAGYSA VFKPDEGVVD PHGYTIASKL NVINSSPTTK  60
   61 RMANALFKSS PMKKLSNSVN DGLSLEGSNG EITGLNNFEW AELVNIQKWR KIFGQLLDMF 120
  121 FRKYFQLLIQ QPFDVARLLI QVGEFKIFKT TVDTNKPQAP IILRDEEGDG AAREGEEDAY 180
  181 DEEEIDFFPI ERKIAEANST APIMAEETDH SHHEPTDISL TIAPQSLHTI DVINALFDQE 240
  241 GIRGLWKANN TTFIYNFLSL SIDTWFTGLL SSFLGVPDPY FMEVINSPDI SKSFILALGA 300
  301 GVFTSIILLP VDLIRTRLIV TSFKKKKNVK TDGKNMVTNT RSLRQLIRCW SWRKNGVSIP 360
  361 LDMWSLTILQ SINNSFFNKL FDLVIYNQFH IEKYSQTVMY NTMKFFSKSL ELFIKLPLEN 420
  421 LLRRCQLNYL LNDQRLSFKV DSTELIVKPK KYNGIWDVIR NNSNTNRGQL WNGWKVGVIS 480
  481 LICGYGLQMM NKVDINMEQE KF

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Krogan NJ, et al. (2006)		ECM3 UGO1 YML131W
View Details	Qiu et al. (2008)		MON1 PUF2 UGO1 YDL133W YGR149W YOR292C

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	ASF1	3908: TAP-tagged, includes hir2(delta) in background	Green EM, et al (2005)
View Run	RPA135	No Comments	Schneider, DA, et al. (2006)

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	UBC7	UGO1	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..153]	MSA	1.108992	View MSA. No confident structure predictions are available.
2	View Details	[154..502]	PSI-BLAST	59.522879	structure of mitochondrial ADP/ATP carrier in complex with carboxyatractyloside

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

[View Details]

Source: Reynolds et al. 2008. Manuscript submitted

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2