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Protein Overview: ARO80

General Information:
Name(s) found: ARO80 / YDR421W [SGD]
Description(s) found:
Found 26 descriptions.
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  • Zinc finger transcriptional activator of the Zn2Cys6 family; activates transcription of aromatic amino acid catabolic genes in the presence of aromatic amino acids [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 950 amino acids

    Gene Ontology:
    Cellular Component: nucleus [ICLink to PubMed article]
    Biological Process: aromatic amino acid family catabolic process [IMPLink to PubMed article]
    positive regulation of transcription from RNA polymerase II promoter [IMPLink to PubMed article]
    Molecular Function: specific RNA polymerase II transcription factor activity [IMPLink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSAKKRPSGN AAFELPKRRR TYQACISCRS RKVKCDLGPV DNPHDPPCAR CKRELKKCIF  60
   61 SSNKGTSNDL PPNSINAISL PSLGKSKQEI QNDSTSPILS DVPLSRKGIS SEKSFKSEGM 120
  121 KWKLELSSMQ NALEFLAQAA GTVAKEGAKE IIKEKSTTPK PLKSSLDATN KSATDEGLKR 180
  181 LSKSDSTNTL YENTADMLNH TLNTNRKTSQ LMEEIGKVRP PPTRKIDDFD YIGPDSLLTK 240
  241 EEAIELIEAF FLTMHPFFPN IPLQLHDPKE LAEYPILFCA ILTVSARYHP FDTLGLDNGE 300
  301 DGMRHIEVHD KLWVYCQKLI SQTIWAEAST RSIGTVLAFI IFTEWNPRSI HYKWSDYAND 360
  361 PELNNVNARG SKNISTRKDE EGLTGVGAIR RSDRMSWMLT GSAVRLAQDM GFIENSSKVF 420
  421 IVTHISETTS AMNMNQRSLL AESFSVLNLN LGKIENDGNE SNEDYLGNEK FYLNEILPDE 480
  481 ESKLRWKRVF ENSENDHDNE KNFLTDWERE FLNDEYVLYY SNKKDDTNLA QNHIPPFPLR 540
  541 FSFAQRAKIE IIRILSIAYE TIYCEKNKRK LATTDQRHNL SVLSVFSPLI EGWLSNYREL 600
  601 LVPLSDVPFS LADRKNKKQI FDNIDRINGE SIITDFNYCQ LYIFSLALQV DGKTSRLNMN 660
  661 EIVTSARYVE LAYRSAKEIL SSAKRVSRQG MLKYMPVRWV IRIIRSIAFI VKCYLTLTGS 720
  721 ELATNPDARN ILKLSAISVD ETFDIIRDTA VTLKEATPDE LHLCQRYAAI LMYLCTEMKL 780
  781 RKKSYLERPP LLRDGTTPLE SNRESSLEGQ DLTKKPIFSK RIGYNKTETT FEPSERPLTE 840
  841 EINSNSQNSN DTSSKGIVDP FVEQNNDITT ALLNNELFQG PSLSDEVTDW FGASEDIGLE 900
  901 FVEPWTELIE QRYMQCGDGD NNNFENLYNL FVNSNNINND INNSRPITRK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #19 Asynchronous Prep1-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #03 Alpha Factor Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #19b Asynchronous Prep1-new search criteria Keck JM, et al. (2011)
    View Run MLP2 #19a Asynchronous Prep1-new search criteria Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data ARO80 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..89] ORFEUS 8.95 Gal4; CD2-Gal4
    2 View Details [90..950] deduced N/A No confident structure predictions are available.
    3 View Details [291..415] MSA 3.026992 View MSA. No confident structure predictions are available.
    4 View Details [416..535] deduced N/A No confident structure predictions are available.
    5 View Details [536..726] deduced N/A No confident structure predictions are available.
    6 View Details [727..795] deduced N/A No confident structure predictions are available.
    7 View Details [796..865] deduced N/A No confident structure predictions are available.
    8 View Details [866..950] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • transcription regulator activity
    		•  4.34861813464065 bayes_pls_golite062009
  • DNA binding
    		•  4.03985756894684 bayes_pls_golite062009
  • nucleic acid binding
    		•  3.97978190843512 bayes_pls_golite062009
  • transcription factor activity
    		•  2.87348461329489 bayes_pls_golite062009
  • binding
    		•  2.82809978070212 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  2.77469997789536 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.70904317608141 bayes_pls_golite062009
  • transcription activator activity
    		•  2.1512787242583 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  2.08956709478484 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.
    7 No functions predicted.
    8 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle