Protein Overview: CAB5

General Information:
Name(s) found:	CAB5 / YDR196C [SGD]
Description(s) found: Found 31 descriptions. SHOW ALL	Probable dephospho-CoA kinase (DPCK) that catalyzes the last step in coenzyme A biosynthesis; null mutant lethality is complemented by E. coli coaE (encoding DPCK); detected in purified mitochondria in high-throughput studies [SGD]
Organism:	Saccharomyces cerevisiae
Length:	241 amino acids
Gene Ontology:
Cellular Component:	nuclear envelope [IDA] mitochondrion [IDA] endoplasmic reticulum [IDA]
Biological Process:	coenzyme A biosynthetic process [ISS]
Molecular Function:	dephospho-CoA kinase activity [ISS ]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLVVGLTGGI ACGKSTVSRR LRDKYKLPIV DADKIARQVV EPGQNAYDQI VLYFKDKIPN  60
   61 LLLEDGHLNR EALGKWVFSH KEDLQALNGI THPAIRYAMF KEIGYYYLKG YRMCVLDVPL 120
  121 LFEGNLDSIC GVTVSVICTQ ELQLERLMTR NPELSEEDAK NRLNSQMSTE ERMARSDYIL 180
  181 QNNSTLVDLY EQIESVVKKI QPSKLRTVLE YFPPFGAVSA SSIVMSRLLM KKLQNKKSSA 240
  241 V

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Gavin AC, et al. (2002)		CAB5 CDC6

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	CAB5	No Comments	Hazbun TR, et al. (2003)
View Run	CAB5	No Comments	Hazbun TR, et al. (2003)
View Run	ZDS1	Sample 3 - cpn + atp, from june 2005	McCusker D, et al (2007)

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	CAB5	ARC35	2	Hazbun TR, et al. (2003)

Microscopy / Localization Data

New Feature: Upload Your Own Microscopy Data

	PROTEIN(S)	PUBLICATION
View Data	CAB5 and SPC42	Hazbun TR, et al. (2003)
View Data	CAB5 and TRX3	Hazbun TR, et al. (2003)
View Data	CAB5	Huh WK, et al. (2003)

Protein Structure Data

[What does the above image mean?]
[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..36] [93..241]	PSI-BLAST	247.94696	Dephospho-CoA kinase
2	View Details	[37..92]	PSI-BLAST	247.94696	Dephospho-CoA kinase

Functions predicted (by domain):

Gene Ontology predictions

Term	Confidence	Notes
dephospho-CoA kinase activity	2.08198137437575	bayes_pls_golite062009
catalytic activity	1.00104173493322	bayes_pls_golite062009
nucleic acid binding	0.727912309521959	bayes_pls_golite062009
DNA binding	0.263924823205515	bayes_pls_golite062009
nucleoside-triphosphatase activity	0.0880086189831292	bayes_pls_golite062009
pyrophosphatase activity	0.0746809525189132	bayes_pls_golite062009
binding	0.0673679334754882	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	0.0557582578674931	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	0.0529869469040288	bayes_pls_golite062009

No functions predicted.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

[View Details]

Source: Reynolds et al. 2008. Manuscript submitted

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2