Protein Overview: YOS9

General Information:
Name(s) found:	YOS9 / YDR057W [SGD]
Description(s) found: Found 31 descriptions. SHOW ALL	ER quality-control lectin; integral subunit of the HRD ligase; binds to glycans with terminal alpha-1,6 linked mannose on misfolded N-glycosylated proteins and participates in targeting proteins to ERAD; member of the OS-9 protein family [SGD]
Organism:	Saccharomyces cerevisiae
Length:	542 amino acids
Gene Ontology:
Cellular Component:	endoplasmic reticulum lumen [IDA]
Biological Process:	ER-associated protein catabolic process [IMP ]
Molecular Function:	sugar binding [IMP][ISS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQAKIIYALS AISALIPLGS SLLAPIEDPI VSNKYLISYI DEDDWSDRIL QNQSVMNSGY  60
   61 IVNMGDDLEC FIQNASTQLN DVLEDSNEHS NSEKTALLTK TLNQGVKTIF DKLNERCIFY 120
  121 QAGFWIYEYC PGIEFVQFHG RVNTKTGEIV NRDESLVYRL GKPKANVEER EFELLYDDVG 180
  181 YYISEIIGSG DICDVTGAER MVEIQYVCGG SNSGPSTIQW VRETKICVYE AQVTIPELCN 240
  241 LELLAKNEDQ KNASPILCRM PAKSKIGSNS IDLITKYEPI FLGSGIYFLR PFNTDERDKL 300
  301 MVTDNAMSNW DEITETYYQK FGNAINKMLS LRLVSLPNGH ILQPGDSCVW LAEVVDMKDR 360
  361 FQTTLSLNIL NSQRAEIFFN KTFTFNEDNG NFLSYKIGDH GESTELGQIT HSNKADINTA 420
  421 EIRSDEYLIN TDNELFLRIS KEIAEVKELL NEIVSPHEME VIFENMRNQP NNDFELALMN 480
  481 KLKSSLNDDN KVEQINNARM DDDESTSHTT RDIGEAGSQT TGNTESEVTN VAAGVFIEHD 540
  541 EL

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	MLP2	#32 Asynchronous Prep-No Phosphopeptide enrichment	Keck JM, et al. (2011)

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	PTC4	YOS9	1	Unpublished Fields Lab Data
View Screen	CNS1	YOS9	1	Unpublished Fields Lab Data
View Screen	YHR122W	YOS9	1	Hazbun TR, et al. (2003)
View Screen	GRR1	YOS9	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..265]	MSA	11.02097	View MSA. No confident structure predictions are available.
2	View Details	[266..542]	deduced	N/A	No confident structure predictions are available.
3	View Details	[241..414]	deduced	N/A	No confident structure predictions are available.
4	View Details	[415..542]	deduced	N/A	No confident structure predictions are available.

Functions predicted (by domain):

Gene Ontology predictions

No functions predicted.

Term	Confidence	Notes
binding	1.16931544864195	bayes_pls_golite062009
receptor activity	0.66788201077791	bayes_pls_golite062009
catalytic activity	0.282237710666423	bayes_pls_golite062009
transmembrane receptor activity	0.272927118711356	bayes_pls_golite062009
signal transducer activity	0.26239044372713	bayes_pls_golite062009
molecular transducer activity	0.26239044372713	bayes_pls_golite062009
protein binding	0.192633833830859	bayes_pls_golite062009
transmembrane receptor protein kinase activity	0.0376900612956657	bayes_pls_golite062009

No functions predicted.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

[View Details]

Source: Reynolds et al. 2008. Manuscript submitted

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2