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Protein Overview: RAD61

General Information:
Name(s) found: RAD61 / YDR014W [SGD]
Description(s) found:
Found 29 descriptions.
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  • Subunit of a complex (Scc3p, Pds5p, Rad61p) that inhibits sister chromatid cohesion; inhibited by Eco1p-acetylated cohesin subunits Smc3p and Mcd1p; related to the human Wapl protein that controls the association of cohesin with chromatin [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 647 amino acids

    Gene Ontology:
    Cellular Component: nucleus [ISSLink to PubMed article]
    Biological Process: response to radiation [IMPLink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRAYGKRGPV LRTPFRSNKG LPSSSDVEFS DDDVNSVIPD VSSTISSSIA DHPIEGLLDE  60
   61 PRKAQDSSSS FDGANEKPSS QLDSKRNDQN VKIITSSDTS MAFMKDEKLS AFNFLDGSKA 120
  121 SKRKRRRTYQ KHDANITSSI EPDVQDEDSI TMHNEFESIR KIYNDINEFI LKLPRADDDI 180
  181 LNKMLENEMK MDDSIENNSI RTSKDKKYGK FRTILINKNK ENEIMGEEVD QKANTLSLNN 240
  241 ADNSNAEKEG LTSTNHYNEL KNMGDTIKYQ DDIEFLLSNS KSNDNTTVPI NEYFKKLLNL 300
  301 SLMIINDEEF FQYAKRYFKK EIIKLSFAQF RSDFPELILL QGYLLHKVSE SQSDFPPSFD 360
  361 NFSIELSKDD GKIRTKKNKH IKKLSHLNFE DFLRKTQFKT GLYYSLSLWE MHGNLSLDII 420
  421 KRISILASNK DLFSRHVKTF IPLLEKLITA SEFCHMYIEQ PEMFDSLISN LNNQFKDMLD 480
  481 DDSLIKILIL LTNMEVHNYT LWKEADMIFQ SSMNTILESI HPLTDAKVDN ILLHLGLCLN 540
  541 ICSRENSRLK LDGKLWYDMK TIFVKMIRDG SDTENRLVQG LFYLNFSFLI KQRKENSNLD 600
  601 PGELNLLLVE LEAFKSETSQ FNEGISNKIE IALNYLKSIY TSERITI

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run MLP2 #24 Asynchronous Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #03 Alpha Factor Prep1-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen SGT1 RAD61 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data RAD61 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..74] deduced N/A No confident structure predictions are available.
    2 View Details [75..354] MSA 1.00292 View MSA. No confident structure predictions are available.
    3 View Details [355..647] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle