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Protein Overview: BRE4

General Information:
Name(s) found: BRE4 / YDL231C [SGD]
Description(s) found:
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  • gi|74583651|sp|Q07660.1|BRE4_YEAST RecName: Full=Protein BRE4; AltName: Full=Brefeldin A-sensitivity protein 4 [NCBI NR]
  • gi|6319970|ref|NP_010050.1| Zinc finger protein containing five transmembrane domains; null mutant exhibits strongly fragmented vacuoles and sensitivity to brefeldin A, a drug which is known to affect intracellular transport; Bre4p [Saccharomyces cerevisi [NCBI NR]
  • pir||S67794 probable membrane protein YDL231c - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|1431390|emb|CAA98810.1| unnamed protein product [Saccharomyces cerevisiae] [NCBI NR]
  • Protein BRE4 OS=Saccharomyces cerevisiae GN=BRE4 PE=1 SV=1 [Swiss-Prot]
  • BRE4 Protein involved in endocytosis [mips]
  • Zinc finger protein containing five transmembrane domains; null mutant exhibits strongly fragmented vacuoles and sensitivity to brefeldin A, a drug which is known to affect intracellular transport [SGD]
  • BRE4, Chr IV from 38868-42245, reverse complement [yeast_orfs2]
  • Chr IV from 38868-42245, reverse complement [yeastorf3.fasta]
  • Chr IV from 42245-38868, reverse complement [yeastorf5.fasta]
  • >Q07660 (Q07660) Chromosome IV reading frame ORF YDL231C [4932.FASTACCERV.txt]
  • BRE4 SGDID:S0002390, Chr IV from 42245-38868, reverse complement, Verified ORF [yeastflysequest.fasta]
  • Bre4p [Saccharomyces cerevisiae]gi|1431390|emb|CAA98810.1| unnamed protein product [Saccharomyces cerevisiae]gi|2132462|pir||S67794 probable membrane protein YDL231c - yeast (Saccharomyces cerevisiae) [nrdb_11152004_Chlamydomonas]
  • (Q07660) S.cerevisiae chromosome IV reading frame ORF YDL231c [cerv4932.FASTAC]
  • BRE4 SGDID:S000002390, Chr IV from 42245-38868, reverse complement, Verified ORF, "Zinc finger protein containing five transmembrane domains; null mutant exhibits strongly fragmented vacuoles and sensitivity to brefeldin A, a drug which is known to affect [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • unnamed protein product [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Zinc finger protein containing five transmembrane domains; null mutant exhibits strongly fragmented vacuoles and sensitivity to brefeldin A, a drug which is known to affect intracellular transport; Bre4p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Protein BRE4 (Brefeldin A-sensitivity protein 4) [nr-271106-contam.fasta]
  • BRE4 SGDID:S000002390, Chr IV from 42245-38868, reverse complement, Verified ORF, "Zinc finger protein containing five transmembrane domains; null mutant exhibits strongly fragmented vacuoles and sensitivity to brefeldin A, a drug which is known to affect intracellular transport" [yeast-bovrabprots.fasta]
  • [chemostatdb.fasta]
  • Protein BRE4 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=BRE4 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • BRE4 SGDID:S000002390, Chr IV from 42244-38867, Genome Release 64-1-1, reverse complement, Verified ORF, "Zinc finger protein containing five transmembrane domains; null mutant exhibits strongly fragmented vacuoles and sensitivity to brefeldin A, a drug which is known to affect intracellular transport" [yeast-030211-contam.fasta]
  • BRE4 SGDID:S000002390, Chr IV from 42244-38867, Genome Release 64-2-1, reverse complement, Verified ORF, "Zinc finger protein containing five transmembrane domains; null mutant exhibits strongly fragmented vacuoles and sensitivity to brefeldin A, a drug which is known to affect intracellular transport" [20141208_orf_trans.fasta]
  • YDL231C SGDID:S000002390, Chr IV from 42244-38867, Genome Release 64-1-1, reverse complement, Verified ORF, "Zinc finger protein containing five transmembrane domains; null mutant exhibits strongly fragmented vacuoles and sensitivity to brefeldin A, a drug which is known to affect intracellular transport" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 1125 amino acids

    Gene Ontology:
    Cellular Component: integral to membrane [ISSLink to PubMed article]
    Biological Process: endocytosis [IMPLink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKRYERDRSP TPDPDIVKGS YSQTSLRSLH ELNYKNPAGI SGLSFAGSPQ QSVASLSQMR  60
   61 LENLVKDKHW EEVEDFGLEE LRDGFFDAAF TKPDSKARSP NSDIDDDNGA ARKKLQSGFT 120
  121 KLSEYVWTAI YRPIIHFPRD IRKNGVSIFK FFIAYFIAIV ICVIRPSGRW IGHEFRYFLP 180
  181 IAVLIHHPVR NIGVQLEMTI SSIIGASFGL GWSALAWYIS TATKPTANYQ GGILFQSLTM 240
  241 ALLFAIWLRS VYRRFFYFTT SFSISIIFTH TVRLASSKFD LKWQIFWDFG ISYLFGLLLS 300
  301 LLVCVCVSPH SGNAELMEHY NKCLQTTKTF LMALVDTELI KSKEQIYLAQ VKMVKTLNID 360
  361 LSQGFRDFVN QLTISRFDLQ SLKSLRNSLT AMETSLRVLP IAPKIFNDDE LKKMYEELEK 420
  421 YRSDSATLSK EASASPQSSG IPTRENTPSA FKPIGPGLLK NEIYINALKA SFSKSIFNLI 480
  481 LEMIFVLENL SRVLKKYESP NQKNNLDECV KILSHSHSKL KRKIYKLDVC YRDFVNSSFF 540
  541 SQELLNDEES VDIFLFLRYL RNSARQLVTV IHDCQVLGEN IHWRIALPSY PLSRALTRLP 600
  601 KQCVLDEGAG NVLHYFEAKR DVDEIFERVY NTYTSRHKYN KGEEEALRLD SQGGDEKSQN 660
  661 RKNHTISIRA IDHNDFNFHT TQNPWRFKLW KLSRILSGDE CKWTLKITFC MIFLCLPTWL 720
  721 PESYHWYQEF HCWWAPLTFY LLAHRRYSGN WALVMRRLIC GIVGIFWGWA ANQSRHFGSP 780
  781 YVVCTFAGLI VVPFSINFLV YRNTKSSFTA LMCFTIIALE PYSKPNRHYN LTTAGIWKST 840
  841 WVTGLALIIG ILVSIPINWI VWPFRARTEL RDSMSSLLAH LGQSYQTVAD RYLYRDADDA 900
  901 PTDLTFAFSH IREVRLTQSL EAIRELLKKA RHEPIIISNF NPEKYASLIN SCQFLLSKII 960
  961 EARISGAFFE IWDQDFDIET TRALLSLRRD SVSSVIFVFY ILSNCFRSKN KIPRYLPNPI1020
 1021 MSRKKLYHFI KKFSEMKDQS HSNLNSGGNS MEKNLFKKIY QQKASSSGQQ QLPLPSVANS1080
 1081 SEIDSEKMHW TEVHGIAFAR AFTDISEALF QVESCAKDIL GEENF

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen CAB2 BRE4 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..103] deduced N/A No confident structure predictions are available.
    2 View Details [104..341] MSA 1.002927 View MSA. No confident structure predictions are available.
    3 View Details [342..1125] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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