Protein Overview: NPC2

General Information:
Name(s) found:	NPC2 / YDL046W [SGD]
Description(s) found: SHOW ONLY BEST	gi\|73621330\|sp\|Q12408.1\|NPC2_YEAST RecName: Full=Phosphatidylglycerol/phosphatidylinositol transfer protein; Short=PG/PI-TP; AltName: Full=NPC2 homolog; Flags: Precursor [NCBI NR] gi\|6320157\|ref\|NP_010237.1\| Functional homolog of human NPC2/He1, which is a cholesterol-binding protein whose deficiency causes Niemann-Pick type C2 disease involving retention of cholesterol in lysosomes; Npc2p [Saccharomyces cerevisiae] [NCBI NR] gi\|51012793\|gb\|AAT92690.1\| YDL046W [Saccharomyces cerevisiae] [NCBI NR] pir\|\|S67579 probable membrane protein YDL046w - yeast (Saccharomyces cerevisiae) [NCBI NR] gi\|1431036\|emb\|CAA98606.1\| unnamed protein product [Saccharomyces cerevisiae] [NCBI NR] gi\|1279670\|emb\|CAA96443.1\| unknown [Saccharomyces cerevisiae] [NCBI NR] Phosphatidylglycerol/phosphatidylinositol transfer protein OS=Saccharomyces cerevisiae GN=NPC2 PE=1 SV=1 [Swiss-Prot] NPC2 Niemann-Pick type C2 disease homolog, involving retention of cholesterol in lysosomes [mips] Functional homolog of human NPC2/He1, which is a cholesterol-binding protein whose deficiency causes Niemann-Pick type C2 disease involving retention of cholesterol in lysosomes [SGD] YDL046W, Chr IV from 371236-371757 [yeast_orfs2] Chr IV from 371236-371757 [yeastorf3.fasta] >Q12408 (Q12408) Chromosome IV reading frame ORF YDL046W [4932.FASTACCERV.txt] NPC2 SGDID:S0002204, Chr IV from 371237-371758, Uncharacterized ORF [yeastflysequest.fasta] Npc2p [Saccharomyces cerevisiae]gi\|51012793\|gb\|AAT92690.1\| YDL046W [Saccharomyces cerevisiae]gi\|1279670\|emb\|CAA96443.1\| unknown [Saccharomyces cerevisiae]gi\|1431036\|emb\|CAA98606.1\| unnamed protein product [Saccharomyces cerevisiae]gi\|2132419\|pir\|\|S675 [nrdb_11152004_Chlamydomonas] (Q12408) ORF YDL046w (Hypothetical protein) [cerv4932.FASTAC] NPC2 SGDID:S000002204, Chr IV from 371237-371758, Verified ORF, "Functional homolog of human NPC2/He1, which is a cholesterol-binding protein whose deficiency causes Niemann-Pick type C2 disease involving retention of cholesterol in lysosomes" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] unnamed protein product [Saccharomyces cerevisiae] [nr-271106-contam.fasta] unknown [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Functional homolog of human NPC2/He1, which is a cholesterol-binding protein whose deficiency causes Niemann-Pick type C2 disease involving retention of cholesterol in lysosomes; Npc2p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] YDL046W [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Phosphatidylglycerol/phosphatidylinositol transfer protein precursor (PG/PI-TP) (NPC2 homolog) [nr-271106-contam.fasta] [chemostatdb.fasta] Phosphatidylglycerol/phosphatidylinositol transfer protein OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=NPC2 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] NPC2 SGDID:S000002204, Chr IV from 371240-371761, Genome Release 64-1-1, Verified ORF, "Functional homolog of human NPC2/He1, which is a cholesterol-binding protein whose deficiency causes Niemann-Pick type C2 disease involving retention of cholesterol in lysosomes" [yeast-030211-contam.fasta] NPC2 SGDID:S000002204, Chr IV from 371240-371761, Genome Release 64-2-1, Verified ORF, "Functional homolog of human NPC2/He1; human NPC2 is a cholesterol-binding protein whose deficiency causes Niemann-Pick type C2 disease involving retention of cholesterol in lysosomes" [20141208_orf_trans.fasta] YDL046W SGDID:S000002204, Chr IV from 371240-371761, Genome Release 64-1-1, Verified ORF, "Functional homolog of human NPC2/He1, which is a cholesterol-binding protein whose deficiency causes Niemann-Pick type C2 disease involving retention of cholesterol in lysosomes" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
Organism:	Saccharomyces cerevisiae
Length:	173 amino acids
Gene Ontology:
Cellular Component:	fungal-type vacuole lumen [IDA] fungal-type vacuole [IDA]
Biological Process:	sterol transport [IGI][ISS]
Molecular Function:	molecular_function [ND]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTHSLKALFA LLFLYTAAVN AGVIGIFNAL PPPNTKPING ESPLYQCDIL DKQLVEIKEV  60
   61 NLDPNPPVRG ENLTISANGE VFETIEEGAY IDVEVRLGYI RLLSQTFDLC ETLEDNDIEG 120
  121 LSCPIEPGEY NIKKIVEIPG EVPPGKYVVV ARAYTEKDDL ITCLTGEVIF PPR

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	CDC13	NPC2	1	Unpublished Fields Lab Data
View Screen	LIA1	NPC2	1	Unpublished Fields Lab Data
View Screen	HMT1	NPC2	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	NPC2	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..173]	FFAS03	4.94	Epididymal secretory protein E1 (Niemann-Pick C2 protein)

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

[View Details]

Source: Reynolds et al. 2008. Manuscript submitted

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2