YRC Public Data Repository - Protein Structure Prediction

Protein:	NPC2
Organism:	Saccharomyces cerevisiae
Length:	173 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for NPC2.

Description	E-value	Query Range	Subject Range
NPC2_ASPOR - Phosphatidylglycerol/phosphatidylinositol transfer protein OS=Aspergillus oryzae (strain ATCC 42149 ... gi\|220694311, gi... - gi\|238496391\|ref\|XP_002379431.1\| ML domain protein, putative [Aspergillus flavus NRRL3357], gi\|22069... NPC2_ASPOR - Phosphatidylglycerol/phosphatidylinositol transfer protein OS=Aspergillus oryzae GN=pltp PE=1 SV=1	212.0	[0..11]	[166..11]
NPC2_SCHPO - Phosphatidylglycerol/phosphatidylinositol transfer protein OS=Schizosaccharomyces pombe (strain 972 ... SPAPB8E5.04c - phosphatidylglycerol /phosphatidylinositol transfer protein	183.0	[0..32]	[170..38]
gi\|6671934, gi\|1... - gi\|6671934\|gb\|AAF23194.1\|AC016795_7 unknown protein [Arabidopsis thaliana], gi\|28393843\|gb\|AAO42329....	174.0	[0..38]	[167..21]
NPC2_KLULA - Phosphatidylglycerol/phosphatidylinositol transfer protein OS=Kluyveromyces lactis (strain ATCC 8585... NPC2_KLULA - Phosphatidylglycerol/phosphatidylinositol transfer protein OS=Kluyveromyces lactis GN=NPC2 PE=3 SV=1	168.0	[0..31]	[171..31]
gi\|159129536 - gi\|159129536\|gb\|EDP54650.1\| ML domain protein, putative [Aspergillus fumigatus A1163] gi\|66853105, gi\|... - gi\|71001572\|ref\|XP_755467.1\| ML domain protein [Aspergillus fumigatus Af293], gi\|66853105\|gb\|EAL9342...	165.0	[0..11]	[166..84]
NPC2_ASHGO - Phosphatidylglycerol/phosphatidylinositol transfer protein OS=Ashbya gossypii (strain ATCC 10895 / C... NPC2_ASHGO - Phosphatidylglycerol/phosphatidylinositol transfer protein OS=Ashbya gossypii GN=NPC2 PE=3 SV=1	163.0	[0..35]	[172..38]
NPC2_ASPFU - Phosphatidylglycerol/phosphatidylinositol transfer protein OS=Aspergillus fumigatus GN=npc2 PE=3 SV=... NPC2_ASPFU - Phosphatidylglycerol/phosphatidylinositol transfer protein OS=Neosartorya fumigata (strain ATCC MYA-...	162.0	[0..11]	[166..11]

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Predicted Domain #1

Region A:
Residues: [1-173]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTHSLKALFA LLFLYTAAVN AGVIGIFNAL PPPNTKPING ESPLYQCDIL DKQLVEIKEV  60
   61 NLDPNPPVRG ENLTISANGE VFETIEEGAY IDVEVRLGYI RLLSQTFDLC ETLEDNDIEG 120
  121 LSCPIEPGEY NIKKIVEIPG EVPPGKYVVV ARAYTEKDDL ITCLTGEVIF PPR

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	4.94
Match:	1nepA
Description:	Epididymal secretory protein E1 (Niemann-Pick C2 protein)
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits