Protein Overview: NPC2

General Information:
Name(s) found:	NPC2 / YDL046W [SGD]
Description(s) found: Found 26 descriptions. SHOW ALL	Functional homolog of human NPC2/He1, which is a cholesterol-binding protein whose deficiency causes Niemann-Pick type C2 disease involving retention of cholesterol in lysosomes [SGD]
Organism:	Saccharomyces cerevisiae
Length:	173 amino acids
Gene Ontology:
Cellular Component:	fungal-type vacuole lumen [IDA] fungal-type vacuole [IDA]
Biological Process:	sterol transport [IGI][ISS]
Molecular Function:	molecular_function [ND]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTHSLKALFA LLFLYTAAVN AGVIGIFNAL PPPNTKPING ESPLYQCDIL DKQLVEIKEV  60
   61 NLDPNPPVRG ENLTISANGE VFETIEEGAY IDVEVRLGYI RLLSQTFDLC ETLEDNDIEG 120
  121 LSCPIEPGEY NIKKIVEIPG EVPPGKYVVV ARAYTEKDDL ITCLTGEVIF PPR

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

	PROTEIN(S)	PUBLICATION
View Data	NPC2	Huh WK, et al. (2003)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..173]	FFAS03	4.94	Epididymal secretory protein E1 (Niemann-Pick C2 protein)

Protein Overview: NPC2

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: