Protein Overview: MPS1

General Information:
Name(s) found:	MPS1 / YDL028C [SGD]
Description(s) found: Found 24 descriptions. SHOW ALL	Dual-specificity kinase required for spindle pole body (SPB) duplication and spindle checkpoint function; substrates include SPB proteins Spc42p, Spc110p, and Spc98p, mitotic exit network protein Mob1p, and checkpoint protein Mad1p [SGD]
Organism:	Saccharomyces cerevisiae
Length:	764 amino acids
Gene Ontology:
Cellular Component:	spindle pole body [IDA] condensed nuclear chromosome kinetochore [IDA]
Biological Process:	mitotic cell cycle spindle assembly checkpoint [TAS] spindle pole body duplication in nuclear envelope [TAS] glycolipid transport [IMP]
Molecular Function:	protein serine/threonine/tyrosine kinase activity [IDA][IMP][ISS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSTNSFHDYV DLKSRTNTRQ FSDDEEFTTP PKLSNFGSAL LSHTEKTSAS EILSSHNNDK  60
   61 IANRLEEMDR SSSRSHPPPS MGNLTSGHTS TSSHSTLFGR YLRNNHQTSM TTMNTSDIEI 120
  121 NVGNSLDKSF ERIRNLRQNM KEDITAKYAE RRSKRFLISN RTTKLGPAKR AMTLTNIFDE 180
  181 DVPNSPNQPI NARETVELPL EDSHQTNFKE RRENTDYDSI DFGDLNPIQY IKKHNLPTSD 240
  241 LPLISQIYFD KQREENRQAA LRKHSSRELL YKSRSSSSSL SSNNLLANKD NSITSNNGSQ 300
  301 PRRKVSTGSS SSKSSIEIRR ALKENIDTSN NSNFNSPIHK IYKGISRNKD SDSEKREVLR 360
  361 NISINANHAD NLLQQENKRL KRSLDDAITN ENINSKNLEV FYHRPAPKPP VTKKVEIVEP 420
  421 AKSASLSNNR NIITVNDSQY EKIELLGRGG SSRVYKVKGS GNRVYALKRV SFDAFDDSSI 480
  481 DGFKGEIELL EKLKDQKRVI QLLDYEMGDG LLYLIMECGD HDLSQILNQR SGMPLDFNFV 540
  541 RFYTKEMLLC IKVVHDAGIV HSDLKPANFV LVKGILKIID FGIANAVPEH TVNIYRETQI 600
  601 GTPNYMAPEA LVAMNYTQNS ENQHEGNKWK VGRPSDMWSC GCIIYQMIYG KPPYGSFQGQ 660
  661 NRLLAIMNPD VKIPFPEHTS NNEKIPKSAI ELMKACLYRN PDKRWTVDKV LSSTFLQPFM 720
  721 ISGSIMEDLI RNAVRYGSEK PHISQDDLND VVDTVLRKFA DYKI

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Qiu et al. (2008)		MPS1 TID3

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	MLP2	#29 Asynchronous Prep5-TiO2 Flowthrough	Keck JM, et al. (2011)

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	HTA1	MPS1	1	Unpublished Fields Lab Data
View Screen	SNP1	MPS1	1	Unpublished Fields Lab Data
View Screen	UBC7	MPS1	1	Unpublished Fields Lab Data

Microscopy / Localization Data

New Feature: Upload Your Own Microscopy Data

	PROTEIN(S)	PUBLICATION
View Data	MPS1	Huh WK, et al. (2003)

Protein Structure Data

[What does the above image mean?]
[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..189]	deduced	N/A	No confident structure predictions are available.
2	View Details	[190..314]	PSI-BLAST	6.69897	pak1 autoregulatory domain
3	View Details	[315..410]	deduced	N/A	Confident ab initio structure predictions are available.
4	View Details	[411..481] [503..517] [753..764]	PSI-BLAST	264.0	cAMP-dependent PK, catalytic subunit
5	View Details	[482..502] [518..752]	PSI-BLAST	264.0	cAMP-dependent PK, catalytic subunit

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2