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Protein Overview: MPS1

General Information:
Name(s) found: MPS1 / YDL028C [SGD]
Description(s) found:
Found 24 descriptions.
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  • Dual-specificity kinase required for spindle pole body (SPB) duplication and spindle checkpoint function; substrates include SPB proteins Spc42p, Spc110p, and Spc98p, mitotic exit network protein Mob1p, and checkpoint protein Mad1p [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 764 amino acids

    Gene Ontology:
    Cellular Component: spindle pole body [IDALink to PubMed article]
    condensed nuclear chromosome kinetochore [IDALink to PubMed article]
    Biological Process: mitotic cell cycle spindle assembly checkpoint [TASLink to PubMed article]
    spindle pole body duplication in nuclear envelope [TASLink to PubMed article]
    glycolipid transport [IMPLink to PubMed article]
    Molecular Function: protein serine/threonine/tyrosine kinase activity [IDALink to PubMed article][IMPLink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSTNSFHDYV DLKSRTNTRQ FSDDEEFTTP PKLSNFGSAL LSHTEKTSAS EILSSHNNDK  60
   61 IANRLEEMDR SSSRSHPPPS MGNLTSGHTS TSSHSTLFGR YLRNNHQTSM TTMNTSDIEI 120
  121 NVGNSLDKSF ERIRNLRQNM KEDITAKYAE RRSKRFLISN RTTKLGPAKR AMTLTNIFDE 180
  181 DVPNSPNQPI NARETVELPL EDSHQTNFKE RRENTDYDSI DFGDLNPIQY IKKHNLPTSD 240
  241 LPLISQIYFD KQREENRQAA LRKHSSRELL YKSRSSSSSL SSNNLLANKD NSITSNNGSQ 300
  301 PRRKVSTGSS SSKSSIEIRR ALKENIDTSN NSNFNSPIHK IYKGISRNKD SDSEKREVLR 360
  361 NISINANHAD NLLQQENKRL KRSLDDAITN ENINSKNLEV FYHRPAPKPP VTKKVEIVEP 420
  421 AKSASLSNNR NIITVNDSQY EKIELLGRGG SSRVYKVKGS GNRVYALKRV SFDAFDDSSI 480
  481 DGFKGEIELL EKLKDQKRVI QLLDYEMGDG LLYLIMECGD HDLSQILNQR SGMPLDFNFV 540
  541 RFYTKEMLLC IKVVHDAGIV HSDLKPANFV LVKGILKIID FGIANAVPEH TVNIYRETQI 600
  601 GTPNYMAPEA LVAMNYTQNS ENQHEGNKWK VGRPSDMWSC GCIIYQMIYG KPPYGSFQGQ 660
  661 NRLLAIMNPD VKIPFPEHTS NNEKIPKSAI ELMKACLYRN PDKRWTVDKV LSSTFLQPFM 720
  721 ISGSIMEDLI RNAVRYGSEK PHISQDDLND VVDTVLRKFA DYKI

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Qiu et al. (2008) MPS1 TID3

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data MPS1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..189] deduced N/A No confident structure predictions are available.
    2 View Details [190..314] PSI-BLAST 6.69897 pak1 autoregulatory domain
    3 View Details [315..410] deduced N/A Confident ab initio structure predictions are available.
    4 View Details [411..481]
    [503..517]
    [753..764]    		 PSI-BLAST 264.0 cAMP-dependent PK, catalytic subunit
    5 View Details [482..502]
    [518..752]    		 PSI-BLAST 264.0 cAMP-dependent PK, catalytic subunit


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle