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View Structure Prediction Details

Protein: MPS1
Organism: Saccharomyces cerevisiae
Length: 764 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MPS1.

Description E-value Query
Range		 Subject
Range
gi|1197058 - gi|1197058|gb|AAA88731.1| protein kinase [Saccharomyces cerevisiae]
 0.0 [1..764] [1..764]
gi|15072452 - gi|15072452|gb|AAK40343.1| protein kinase 1 [Cryphonectria parasitica]
 0.0 [150..761] [10..591]
gi|9716257 - gi|9716257|emb|CAC01625.1| protein kinase C homologue [Tuber borchii]
 0.0 [206..761] [553..1109]
KPC2_APLCA - Calcium-independent protein kinase C OS=Aplysia californica GN=PRKC2 PE=1 SV=1
 0.0 [351..761] [314..703]
gi|15074866 - gi|15074866|emb|CAC48007.1| protein kinase C homologue [Tuber magnatum]
 0.0 [206..761] [418..974]
PRKCE - protein kinase C, epsilon
gi|168279093 - gi|168279093|dbj|BAG11426.1| protein kinase C epsilon type [synthetic construct]
 0.0 [327..761] [306..707]
KPCE_RABIT - Protein kinase C epsilon type OS=Oryctolagus cuniculus GN=PRKCE PE=2 SV=1
 0.0 [327..761] [306..706]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
 0.0 [327..761] [306..706]

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Predicted Domain #1
Region A:
Residues: [1-189] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSTNSFHDYV DLKSRTNTRQ FSDDEEFTTP PKLSNFGSAL LSHTEKTSAS EILSSHNNDK  60
   61 IANRLEEMDR SSSRSHPPPS MGNLTSGHTS TSSHSTLFGR YLRNNHQTSM TTMNTSDIEI 120
  121 NVGNSLDKSF ERIRNLRQNM KEDITAKYAE RRSKRFLISN RTTKLGPAKR AMTLTNIFDE 180
  181 DVPNSPNQP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [190-314] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 INARETVELP LEDSHQTNFK ERRENTDYDS IDFGDLNPIQ YIKKHNLPTS DLPLISQIYF  60
   61 DKQREENRQA ALRKHSSREL LYKSRSSSSS LSSNNLLANK DNSITSNNGS QPRRKVSTGS 120
  121 SSSKS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 6.69897
Match: 1f3mA_
Description: pak1 autoregulatory domain
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [315-410] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SIEIRRALKE NIDTSNNSNF NSPIHKIYKG ISRNKDSDSE KREVLRNISI NANHADNLLQ  60
   61 QENKRLKRSL DDAITNENIN SKNLEVFYHR PAPKPP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

    MCM
Score		 GO
Score		 GO
Term		 SCOP
Match		 SCOP Description
View Download 0.859 0.027 spindle pole body duplication in nuclear envelope a.4.12 TrpR-like

Predicted Domain #4
Region A:
Residues: [411-481] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VTKKVEIVEP AKSASLSNNR NIITVNDSQY EKIELLGRGG SSRVYKVKGS GNRVYALKRV  60
   61 SFDAFDDSSI D

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [503-517] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LDYEMGDGLL YLIME

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [753-764] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DTVLRKFADY KI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 264.0
Match: 1ctpE_
Description: cAMP-dependent PK, catalytic subunit
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [482-502] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GFKGEIELLE KLKDQKRVIQ L

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [518-752] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 CGDHDLSQIL NQRSGMPLDF NFVRFYTKEM LLCIKVVHDA GIVHSDLKPA NFVLVKGILK  60
   61 IIDFGIANAV PEHTVNIYRE TQIGTPNYMA PEALVAMNYT QNSENQHEGN KWKVGRPSDM 120
  121 WSCGCIIYQM IYGKPPYGSF QGQNRLLAIM NPDVKIPFPE HTSNNEKIPK SAIELMKACL 180
  181 YRNPDKRWTV DKVLSSTFLQ PFMISGSIME DLIRNAVRYG SEKPHISQDD LNDVV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 264.0
Match: 1ctpE_
Description: cAMP-dependent PK, catalytic subunit
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle