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View Structure Prediction Details

Protein: MPS1
Organism: Saccharomyces cerevisiae
Length: 764 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MPS1.

Description E-value Query
Range		 Subject
Range
gi|1197058 - gi|1197058|gb|AAA88731.1| protein kinase [Saccharomyces cerevisiae]
 0.0 [1..764] [1..764]
gi|15072452 - gi|15072452|gb|AAK40343.1| protein kinase 1 [Cryphonectria parasitica]
 0.0 [150..761] [10..591]
gi|9716257 - gi|9716257|emb|CAC01625.1| protein kinase C homologue [Tuber borchii]
 0.0 [206..761] [553..1109]
KPC2_APLCA - Calcium-independent protein kinase C OS=Aplysia californica GN=PRKC2 PE=1 SV=1
 0.0 [351..761] [314..703]
gi|15074866 - gi|15074866|emb|CAC48007.1| protein kinase C homologue [Tuber magnatum]
 0.0 [206..761] [418..974]
PRKCE - protein kinase C, epsilon
gi|168279093 - gi|168279093|dbj|BAG11426.1| protein kinase C epsilon type [synthetic construct]
 0.0 [327..761] [306..707]
KPCE_RABIT - Protein kinase C epsilon type OS=Oryctolagus cuniculus GN=PRKCE PE=2 SV=1
 0.0 [327..761] [306..706]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
 0.0 [327..761] [306..706]

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Predicted Domain #1
Region A:
Residues: [1-189] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSTNSFHDYV DLKSRTNTRQ FSDDEEFTTP PKLSNFGSAL LSHTEKTSAS EILSSHNNDK  60
   61 IANRLEEMDR SSSRSHPPPS MGNLTSGHTS TSSHSTLFGR YLRNNHQTSM TTMNTSDIEI 120
  121 NVGNSLDKSF ERIRNLRQNM KEDITAKYAE RRSKRFLISN RTTKLGPAKR AMTLTNIFDE 180
  181 DVPNSPNQP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [190-314] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 INARETVELP LEDSHQTNFK ERRENTDYDS IDFGDLNPIQ YIKKHNLPTS DLPLISQIYF  60
   61 DKQREENRQA ALRKHSSREL LYKSRSSSSS LSSNNLLANK DNSITSNNGS QPRRKVSTGS 120
  121 SSSKS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 6.69897
Match: 1f3mA_
Description: pak1 autoregulatory domain
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [315-410] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SIEIRRALKE NIDTSNNSNF NSPIHKIYKG ISRNKDSDSE KREVLRNISI NANHADNLLQ  60
   61 QENKRLKRSL DDAITNENIN SKNLEVFYHR PAPKPP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score		 GO
Score		 GO
Term		 SCOP
Match		 SCOP Description
View Download 0.680 0.027 spindle pole body duplication in nuclear envelope a.4.1 Homeodomain-like
View Download 0.859 0.027 spindle pole body duplication in nuclear envelope a.4.12 TrpR-like
View Download 0.848 0.027 spindle pole body duplication in nuclear envelope a.37.1 A DNA-binding domain in eukaryotic transcription factors
View Download 0.698 0.027 spindle pole body duplication in nuclear envelope a.46.1 Methionine synthase domain
View Download 0.669 0.027 spindle pole body duplication in nuclear envelope a.4.12 TrpR-like
View Download 0.667 0.027 spindle pole body duplication in nuclear envelope a.4.1 Homeodomain-like
View Download 0.624 0.027 spindle pole body duplication in nuclear envelope a.4.6 C-terminal effector domain of the bipartite response regulators
View Download 0.597 0.027 spindle pole body duplication in nuclear envelope a.4.5 "Winged helix" DNA-binding domain
View Download 0.532 0.027 spindle pole body duplication in nuclear envelope a.4.5 "Winged helix" DNA-binding domain
View Download 0.529 0.027 spindle pole body duplication in nuclear envelope a.100.1 6-phosphogluconate dehydrogenase C-terminal domain-like
View Download 0.529 0.027 spindle pole body duplication in nuclear envelope a.4.1 Homeodomain-like
View Download 0.526 0.027 spindle pole body duplication in nuclear envelope a.65.1 Annexin
View Download 0.505 0.027 spindle pole body duplication in nuclear envelope a.4.6 C-terminal effector domain of the bipartite response regulators
View Download 0.501 0.027 spindle pole body duplication in nuclear envelope a.4.5 "Winged helix" DNA-binding domain
View Download 0.499 0.027 spindle pole body duplication in nuclear envelope a.135.1 Tetraspanin
View Download 0.486 0.027 spindle pole body duplication in nuclear envelope a.74.1 Cyclin-like
View Download 0.481 0.027 spindle pole body duplication in nuclear envelope a.4.12 TrpR-like
View Download 0.481 0.027 spindle pole body duplication in nuclear envelope a.73.1 Retrovirus capsid protein, N-terminal core domain
View Download 0.477 0.027 spindle pole body duplication in nuclear envelope a.4.5 "Winged helix" DNA-binding domain
View Download 0.477 0.027 spindle pole body duplication in nuclear envelope a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.467 0.027 spindle pole body duplication in nuclear envelope a.151.1 Glutamyl tRNA-reductase dimerization domain
View Download 0.447 0.027 spindle pole body duplication in nuclear envelope a.4.1 Homeodomain-like
View Download 0.447 0.027 spindle pole body duplication in nuclear envelope a.4.6 C-terminal effector domain of the bipartite response regulators
View Download 0.436 0.027 spindle pole body duplication in nuclear envelope a.4.11 RNA polymerase subunit RPB10
View Download 0.433 0.027 spindle pole body duplication in nuclear envelope a.60.1 SAM/Pointed domain
View Download 0.432 0.027 spindle pole body duplication in nuclear envelope a.56.1 CO dehydrogenase ISP C-domain like
View Download 0.422 0.027 spindle pole body duplication in nuclear envelope a.23.4 Mitochondrial import receptor subunit Tom20
View Download 0.412 0.027 spindle pole body duplication in nuclear envelope a.4.5 "Winged helix" DNA-binding domain
View Download 0.410 0.027 spindle pole body duplication in nuclear envelope a.4.6 C-terminal effector domain of the bipartite response regulators
View Download 0.410 0.027 spindle pole body duplication in nuclear envelope d.56.1 GroEL-intermediate domain like
View Download 0.404 0.027 spindle pole body duplication in nuclear envelope a.1.1 Globin-like
View Download 0.394 0.027 spindle pole body duplication in nuclear envelope a.56.1 CO dehydrogenase ISP C-domain like
View Download 0.390 0.027 spindle pole body duplication in nuclear envelope a.4.6 C-terminal effector domain of the bipartite response regulators
View Download 0.374 0.027 spindle pole body duplication in nuclear envelope d.58.43 Mechanosensitive channel protein MscS (YggB), C-terminal domain
View Download 0.356 0.027 spindle pole body duplication in nuclear envelope a.4.1 Homeodomain-like
View Download 0.345 0.027 spindle pole body duplication in nuclear envelope a.11.2 Second domain of FERM
View Download 0.340 0.027 spindle pole body duplication in nuclear envelope a.1.1 Globin-like
View Download 0.340 0.027 spindle pole body duplication in nuclear envelope a.4.6 C-terminal effector domain of the bipartite response regulators
View Download 0.340 0.027 spindle pole body duplication in nuclear envelope a.4.13 Sigma3 and sigma4 domains of RNA polymerase sigma factors
View Download 0.338 0.027 spindle pole body duplication in nuclear envelope a.4.1 Homeodomain-like
View Download 0.335 0.027 spindle pole body duplication in nuclear envelope a.24.7 FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)
View Download 0.333 0.027 spindle pole body duplication in nuclear envelope a.4.5 "Winged helix" DNA-binding domain
View Download 0.332 0.027 spindle pole body duplication in nuclear envelope a.7.5 Tubulin chaperone cofactor A
View Download 0.328 0.027 spindle pole body duplication in nuclear envelope a.4.5 "Winged helix" DNA-binding domain
View Download 0.328 0.027 spindle pole body duplication in nuclear envelope a.60.9 lambda integrase-like, N-terminal domain
View Download 0.324 0.027 spindle pole body duplication in nuclear envelope a.4.5 "Winged helix" DNA-binding domain
View Download 0.323 0.027 spindle pole body duplication in nuclear envelope a.4.6 C-terminal effector domain of the bipartite response regulators
View Download 0.322 0.027 spindle pole body duplication in nuclear envelope a.121.1 Tetracyclin repressor-like, C-terminal domain
View Download 0.319 0.027 spindle pole body duplication in nuclear envelope a.46.2 Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain
View Download 0.316 0.027 spindle pole body duplication in nuclear envelope a.118.11 Cytochrome c oxidase subunit E
View Download 0.314 0.027 spindle pole body duplication in nuclear envelope d.15.6 Superantigen toxins, C-terminal domain
View Download 0.314 0.027 spindle pole body duplication in nuclear envelope a.24.13 Domain of the SRP/SRP receptor G-proteins
View Download 0.311 0.027 spindle pole body duplication in nuclear envelope a.4.5 "Winged helix" DNA-binding domain
View Download 0.298 0.027 spindle pole body duplication in nuclear envelope d.68.3 SirA-like
View Download 0.296 0.027 spindle pole body duplication in nuclear envelope a.142.1 PTS-regulatory domain, PRD
View Download 0.292 0.027 spindle pole body duplication in nuclear envelope a.21.1 HMG-box
View Download 0.291 0.027 spindle pole body duplication in nuclear envelope a.36.1 Signal peptide-binding domain
View Download 0.290 0.027 spindle pole body duplication in nuclear envelope a.4.6 C-terminal effector domain of the bipartite response regulators
View Download 0.289 0.027 spindle pole body duplication in nuclear envelope a.118.1 ARM repeat
View Download 0.281 0.027 spindle pole body duplication in nuclear envelope a.28.1 ACP-like
View Download 0.278 0.027 spindle pole body duplication in nuclear envelope a.141.1 Frizzled cystein-rich domain
View Download 0.278 0.027 spindle pole body duplication in nuclear envelope a.77.1 DEATH domain
View Download 0.278 0.027 spindle pole body duplication in nuclear envelope a.118.9 ENTH/VHS domain
View Download 0.277 0.027 spindle pole body duplication in nuclear envelope d.188.1 Prokaryotic ribosomal protein L17
View Download 0.277 0.027 spindle pole body duplication in nuclear envelope a.80.1 DNA polymerase III clamp loader subunits, C-terminal domain
View Download 0.277 0.027 spindle pole body duplication in nuclear envelope a.74.1 Cyclin-like
View Download 0.273 0.027 spindle pole body duplication in nuclear envelope a.133.1 Phospholipase A2, PLA2
View Download 0.273 0.027 spindle pole body duplication in nuclear envelope a.11.1 Acyl-CoA binding protein
View Download 0.270 0.027 spindle pole body duplication in nuclear envelope a.60.6 DNA polymerase beta, N-terminal domain-like
View Download 0.266 0.027 spindle pole body duplication in nuclear envelope a.118.8 TPR-like
View Download 0.265 0.027 spindle pole body duplication in nuclear envelope g.57.1 Serine proteinase inhibitor lekti
View Download 0.262 0.027 spindle pole body duplication in nuclear envelope a.1.1 Globin-like
View Download 0.260 0.027 spindle pole body duplication in nuclear envelope a.2.3 Chaperone J-domain
View Download 0.260 0.027 spindle pole body duplication in nuclear envelope a.22.1 Histone-fold
View Download 0.258 0.027 spindle pole body duplication in nuclear envelope a.4.2 Methylated DNA-protein cysteine methyltransferase, C-terminal domain
View Download 0.254 0.027 spindle pole body duplication in nuclear envelope a.50.1 Anaphylotoxins (complement system)
View Download 0.249 0.027 spindle pole body duplication in nuclear envelope a.4.3 ARID-like
View Download 0.242 0.027 spindle pole body duplication in nuclear envelope a.39.3 Cloroperoxidase
View Download 0.242 0.027 spindle pole body duplication in nuclear envelope a.118.8 TPR-like
View Download 0.242 0.027 spindle pole body duplication in nuclear envelope a.4.1 Homeodomain-like
View Download 0.234 0.027 spindle pole body duplication in nuclear envelope a.4.5 "Winged helix" DNA-binding domain
View Download 0.233 0.027 spindle pole body duplication in nuclear envelope a.4.2 Methylated DNA-protein cysteine methyltransferase, C-terminal domain
View Download 0.233 0.027 spindle pole body duplication in nuclear envelope a.60.2 RuvA domain 2-like
View Download 0.228 0.027 spindle pole body duplication in nuclear envelope a.29.2 Bromodomain
View Download 0.227 0.027 spindle pole body duplication in nuclear envelope a.24.15 FAD-dependent thiol oxidase
View Download 0.227 0.027 spindle pole body duplication in nuclear envelope a.159.2 FF domain
View Download 0.219 0.027 spindle pole body duplication in nuclear envelope a.7.1 Spectrin repeat
View Download 0.216 0.027 spindle pole body duplication in nuclear envelope d.228.1 Replication modulator SeqA, C-terminal DNA-binding domain
View Download 0.214 0.027 spindle pole body duplication in nuclear envelope a.2.3 Chaperone J-domain
View Download 0.213 0.027 spindle pole body duplication in nuclear envelope a.118.1 ARM repeat
View Download 0.212 0.027 spindle pole body duplication in nuclear envelope a.118.16 Testis/brain RNA-binding protein (TB-RBP)
View Download 0.209 0.027 spindle pole body duplication in nuclear envelope a.4.9 Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3
View Download 0.204 0.027 spindle pole body duplication in nuclear envelope d.55.1 Ribosomal protein L22

Predicted Domain #4
Region A:
Residues: [411-481] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VTKKVEIVEP AKSASLSNNR NIITVNDSQY EKIELLGRGG SSRVYKVKGS GNRVYALKRV  60
   61 SFDAFDDSSI D

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [503-517] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LDYEMGDGLL YLIME

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [753-764] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DTVLRKFADY KI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 264.0
Match: 1ctpE_
Description: cAMP-dependent PK, catalytic subunit
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [482-502] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GFKGEIELLE KLKDQKRVIQ L

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [518-752] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 CGDHDLSQIL NQRSGMPLDF NFVRFYTKEM LLCIKVVHDA GIVHSDLKPA NFVLVKGILK  60
   61 IIDFGIANAV PEHTVNIYRE TQIGTPNYMA PEALVAMNYT QNSENQHEGN KWKVGRPSDM 120
  121 WSCGCIIYQM IYGKPPYGSF QGQNRLLAIM NPDVKIPFPE HTSNNEKIPK SAIELMKACL 180
  181 YRNPDKRWTV DKVLSSTFLQ PFMISGSIME DLIRNAVRYG SEKPHISQDD LNDVV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 264.0
Match: 1ctpE_
Description: cAMP-dependent PK, catalytic subunit
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle