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Protein Overview: ERS1

General Information:
Name(s) found: ERS1 / YCR075C [SGD]
Description(s) found:
Found 27 descriptions.
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  • Protein with similarity to human cystinosin, which is a H(+)-driven transporter involved in L-cystine export from lysosomes and implicated in the disease cystinosis; contains seven transmembrane domains [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 260 amino acids

    Gene Ontology:
    Cellular Component: endosome [IDALink to PubMed article]
    vacuole [IDALink to PubMed article]
    Biological Process: L-cystine transport [IGILink to PubMed article][ISSLink to PubMed article]
    Molecular Function: L-cystine transmembrane transporter activity [IGILink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVSLDDILGI VYVTSWSISM YPPIITNWRH KSASAISMDF VMLNTAGYSY LVISIFLQLY  60
   61 CWKMTGDESD LGRPKLTQFD FWYCLHGCLM NVVLLTQVVA GARIWRFPGK GHRKMNPWYL 120
  121 RILLASLAIF SLLTVQFMYS NYWYDWHNSR TLAYCNNLFL LKISMSLIKY IPQVTHNSTR 180
  181 KSMDCFPIQG VFLDVTGGIA SLLQLIWQLS NDQGFSLDTF VTNFGKVGLS MVTLIFNFIF 240
  241 IMQWFVYRSR GHDLASEYPL

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Qiu et al. (2008) ERS1 GAP1 MUP1 SAM3

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..108] deduced N/A Confident ab initio structure predictions are available.
    2 View Details [109..260] MSA 1.009964 View MSA. No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle