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Protein Overview: SED4

General Information:
Name(s) found: SED4 / YCR067C [SGD]
Description(s) found:
Found 26 descriptions.
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  • Integral endoplasmic reticulum membrane protein, functions as a positive regulator of Sar1p probably through inhibition of GTPase activation by Sec23p; binds Sec16p, participates in vesicle formation, similar to Sec12p [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1065 amino acids

    Gene Ontology:
    Cellular Component: integral to endoplasmic reticulum membrane [IDALink to PubMed article]
    endoplasmic reticulum [TASLink to PubMed article]
    Biological Process: ER to Golgi vesicle-mediated transport [IGILink to PubMed article][IMPLink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSGNSANYDV GYPIYGAKFI NEGTLLVAGG GGQFNSSFPN KITALKVNFQ KKKHIRRFRE  60
   61 ITLDSIDDAP TSLDCNNNLI LVGCNELFND SSMENVNHHL RKFVFEQEHL KFVASIDFNR 120
  121 TTDPSVFTKF VYINQRATVA AIASSEVPTV IRIIDPRNLT ENYEIETGRE VNDLHFAPNG 180
  181 ILLSYITSNS LEVASVRDGN FVARKTDFDK NLVLSNIRFL NDNTLLVAAS LSNSDGVSLL 240
  241 KLGVSSKGVK ILKTASFMFD LNGITSMDVS PNKKFVALSS NDNLVAIVSV EKLKLVQLVP 300
  301 RVHESTITKV TFSPDSRYLA STSMGNTINV LKLSGTSSSI LRNIWKFFLN FVLLVVLAGA 360
  361 IQLGYKHNVH GFIYKHAHDI YKSKFKENTT IDQGSSSYFT INDDYRGITE SADIISATDV 420
  421 ASDIETEFSS FDTSTMRTTT EDEQKFVWIS SSADSQFTSA DIPTSASSSS SSSSSSFYEE 480
  481 SVTNEPIVSS PTSEITKPLA SPTEPNIVEK PSLPLNSESI DLLSSSSNSI TEYPEPTPDL 540
  541 EEKLSSLIVE QSESEITTDR ESVSKLLSTE SPSLSHMPSS SSSSLSLSSS LTTSPTTALS 600
  601 TSTATAVTTT QTNPTNDAAN TSFLDNSKPA STREIYKTKI ITEVITKIEY RNIPASDSNA 660
  661 EAEQYVTTSS SMLLTPTDTM VSSPVSEIDP IASELERMVE TPTHSISIAS EFDSVASNLI 720
  721 PNEEILSTSA SQDSISSHPS TFSDSSITSG FQSIEVSTVT SSVLASESIP SISDSTFSKF 780
  781 HSISEPVSSA IVETATSSFS KTETKTSRVI AFSTEDSERS SALIDNSEYT SVLADNLEPT 840
  841 SVLADNSEPT SVLADSSEPT SVFTDAVQSP KTSVGQSSLS ESTNIEGTSM ASMIFSSSGA 900
  901 SIGALSDIGK GTLSVESASS TVAQPMPGVT TTAPSFVSSP HKISASSIDA SGFVQKEIMI 960
  961 EVQSSKDSSE AFGVRHKISE NVNTPVSRML TTEMQASGTV DVTEDVSLSS EVISALNVEI1020
 1021 TSLPNPVAPP QTIAAPLNNN SNTNIVNDDN AVAGTVNYAG LHDEL

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Qiu et al. (2008) ERV25 SED4

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #24 Asynchronous Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #26 Asynchronous Prep4-TiO2 Phosphopeptide enriched, Steps1-2 Keck JM, et al. (2011)
    View Run MLP2 #31 Asynchronous Prep (Protease cleavage) Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data SED4 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..93] PSI-BLAST 39.522879 No description for 1scgB_ was found.
    2 View Details [94..432] PSI-BLAST 59.221849 beta1-subunit of the signal-transducing G protein heterotrimer
    3 View Details [433..728] ORFEUS 13.88 Sec24
    4 View Details [729..926] ORFEUS 11.77 Fibrinogen
    5 View Details [927..1065] MSA 1.209997 View MSA. Confident ab initio structure predictions are available.
    6 View Details [889..1065] MSA 1.128993 View MSA. No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.52

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle