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Protein Overview: BPH1

General Information:
Name(s) found: BPH1 / YCR032W [SGD]
Description(s) found:
Found 26 descriptions.
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  • PProtein homologous to human Chediak-Higashi syndrome and murine Beige proteins, which are implicated in disease syndromes due to defective lysosomal trafficking; mutant phenotype and genetic interactions suggest a role in protein sorting [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 2167 amino acids

    Gene Ontology:
    Cellular Component: soluble fraction [IDALink to PubMed article]
    mitochondrion [IDALink to PubMed articleLink to PubMed article]
    peripheral to membrane of membrane fraction [IDALink to PubMed article]
    Biological Process: cellular cell wall organization [IMPLink to PubMed article]
    response to pH [IMPLink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNSIINAASK VLRLQDDVKK ATIILGDILI LQPINHEVEP DVENLVQHEL TKIIQGYPIQ  60
   61 DNMIINSKKG TVEDDLCELN NYTCFALSKS FDLCHDSRNF NIAQPKRWIQ LLETLTDSVS 120
  121 FAVIVQIILT LSNISLINKQ TLGKLKKLRI RIFEILSNKN DSWKSTLLQK NLIEWYIFML 180
  181 SVDCTPLELQ NLYLHKELKF CNGILNSLTL QVSDPRSQNY LQFENTYKLF QIQKSSRINN 240
  241 SFLFYIEFNS VTSNRIMTIE RHIYLEIKEG QFCISNDNYI IGLFENFEFE AGTLYFIGVL 300
  301 IDHNNRITLY VDGSMINQLT LFENSICQLS TCELGSMICS IKVYRFYLWD GLLTEFAINI 360
  361 LQAIGTNYQY TFSKKKEGPE VLSLCQDFLI AKAHLMARPT TEISSTKYID EIELLEMENI 420
  421 IIDVNPNDIL QDFTESSNFT VKFEESTNSK NIPEVGKCYF YRSSNLVSKF VSIDSIRLAF 480
  481 LNMTESGSID DLFHHVSHLM NLLRNIDILN WFKKDFGFPL FAYTLKQKIT QDLSQPLNIQ 540
  541 FFNLFLEFCG WDFNDISKSI ILDTDAYENI VLNLDLWYMN EDQSSLASGG LEIIRFLFFQ 600
  601 ISSLMEASIY SKFNSNKFND MNILEKLCLS YQAVTKRENQ NSKFNELSSD LISVFVTLLK 660
  661 SNTDKRHLQW FLHLSYYFIK RKDVRSTEII LQAVDQLFSF YLDQGSDENA KILSEIIPLK 720
  721 LILMIMDQIV ENNESNPITC LNILFKVVLT NKPLFKQFYK NDGLKLILTM LCKVGKSYRE 780
  781 EIISLLLTYS IGNYTTANEI FSGAEDMIGG ISNDKITAKE IIYLAVNFIE WHVINSNASD 840
  841 SSSVLDLNNH ILRFVEDLKS LSAVPINESV FDPKKSYVMV SLLDLSIALN ESEDISKFKS 900
  901 SSKVISELIK GNIMCALTKY AAYDFEVYMS TFFCHSTEYK LVYPKTVMNN SSYLELSFIV 960
  961 TLLPEILNDL VDSNNNLNLM MLKHPYTMSN LLYFLRKFRP DTSQIVMPKD FYFSSYTCLL1020
 1021 HCVIQIDKSS FYHFKNVSKS QLLQDFKICI MNLIYSNTLK QIIWEKEEYE MFSESLMAHQ1080
 1081 EVLFAHGACD NETVGLLLIF FANRLRDCGY NKAVFNCMKV IIKNKERKLK EVACFFDPAN1140
 1141 KSEVLEGLSN ILSCNNSETM NLITEQYPFF FNNTQQVRFI NIVTNILFKN NNFSPISVRQ1200
 1201 IKNQVYEWKN ARSEYVTQNN KKCLILFRKD NTSLDFKIKK SISRYTYNLK TDREENAVFY1260
 1261 RNNLNLLIFH LKHTLEIQSN PNSSCKWSSD FAEDFDGMKR RLLPAWEPKY EPLINEEDAN1320
 1321 QDTITGGNRQ RRESGSILSY EFIEHMETLE SEPVGDLNEN RKILRLLKDN DSIATIWNCS1380
 1381 LIIGLEIKEG ILIHGSNYLY FVSDYYFSLE DKKILKLSEV SQESRDMTVS LINGPDVKRV1440
 1441 STFLKHEVFV WKLLDITFVT KRPFLLRDVA IELLFKERVS AFFSFYNKRV RDDVLRVLNK1500
 1501 IPKHLPADPI FSSVLQEIND RGNSIVARNG IGKASIASKF TSVFSANNSL IDGFEISKKW1560
 1561 VRGEISNFYY LLSINILAGR SFNDLTQYPV FPWVIADYES NVLDLENPKT YRDLSKPMGA1620
 1621 QSEKRKLQFI ERYEALASLE NADSAPFHYG THYSSAMIVS SYLIRLKPFV ESFLLLQGGS1680
 1681 FGPADRLFSS LERAWSSASS ENTTDVRELT PEFFFLPEFL INVNSYDFGT DQSGKKVDDV1740
 1741 VLPPWANGDP KVFIQKNREA LESPYVSAHL HEWIDLIFGY KQKGDIAVKS VNVFNRLSYP1800
 1801 GAVNLDNIDD ENERRAITGI IHNFGQTPLQ IFQEPHPEKI ACNVQQLTTE VWRKVPMKPI1860
 1861 FEKTIFNLNE KNRSVDYVIH DPSYFDSLYW RGFAFPNLFF RTEESLVSLR IVHKNWLKIG1920
 1921 LDIFKKTHMA QITSFAYWKL GEFITGDKNG LIKVWKYRKD KHSVSGNLEN KKTMFGHLCE1980
 1981 LKEMRCYHDY NTLLTLDISG LVYVWDMINF ELVRQITNDA QKVAISQHAG SIMVLTKNNA2040
 2041 ISIFNLNGQI YTSKKFEPAK IVSSIDFFDF TKLDAGYRKH IYWKEMEILL VGFEDGTIEI2100
 2101 YELFLNFHNE WAIKLLKQLC TEKGKAITSI KGQGKTYLSQ KRRKDTAEPH EIEVIAGTLD2160
 2161 GRLAIWY

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) BPH1 YOL057W

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..1252] deduced N/A No confident structure predictions are available.
    2 View Details [1253..1432] MSA 1.024984 View MSA. No confident structure predictions are available.
    3 View Details [1433..1522] deduced N/A No confident structure predictions are available.
    4 View Details [1523..1803] Pfam 177.853872 Beige/BEACH domain No confident structure predictions are available.
    5 View Details [1804..2167] PSI-BLAST 72.0 beta1-subunit of the signal-transducing G protein heterotrimer
    6 View Details [1279..1366] deduced N/A No confident structure predictions are available.
    7 View Details [1367..1841] PSI-BLAST 167.0 Crystal structure of the PH-BEACH domains of human LRBA/BGL
    8 View Details [1842..2167] PSI-BLAST 71.30103 F-box/WD-repeat protein 1 (beta-TRCP1)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.
    7 No functions predicted.
    8
    Term Confidence Notes
  • binding
    		•  1.8484919978091 bayes_pls_golite062009
  • protein binding
    		•  1.42618832381942 bayes_pls_golite062009
  • transporter activity
    		•  0.482752505032799 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.78

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle