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View Structure Prediction Details

Protein: BPH1
Organism: Saccharomyces cerevisiae
Length: 2167 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for BPH1.

Description E-value Query
Range
Subject
Range
gi|4806 - gi|4806|emb|CAA41798.1| YCR591 [Saccharomyces cerevisiae]
0.0 [335..2167] [1..1833]
gi|10047289 - gi|10047289|dbj|BAB13433.1| KIAA1607 protein [Homo sapiens]
0.0 [1278..2166] [362..1266]
LRBA_MOUSE - Lipopolysaccharide-responsive and beige-like anchor protein OS=Mus musculus GN=Lrba PE=1 SV=1
0.0 [1264..2167] [1954..2849]
gi|4587572, gi|2... - gi|4587572|gb|AAD25803.1|AC006550_11 Similar to gb|U70015 lysosomal trafficking regulator from Mus m...
0.0 [1321..2166] [2708..3568]

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Predicted Domain #1
Region A:
Residues: [1-1252]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNSIINAASK VLRLQDDVKK ATIILGDILI LQPINHEVEP DVENLVQHEL TKIIQGYPIQ  60
   61 DNMIINSKKG TVEDDLCELN NYTCFALSKS FDLCHDSRNF NIAQPKRWIQ LLETLTDSVS 120
  121 FAVIVQIILT LSNISLINKQ TLGKLKKLRI RIFEILSNKN DSWKSTLLQK NLIEWYIFML 180
  181 SVDCTPLELQ NLYLHKELKF CNGILNSLTL QVSDPRSQNY LQFENTYKLF QIQKSSRINN 240
  241 SFLFYIEFNS VTSNRIMTIE RHIYLEIKEG QFCISNDNYI IGLFENFEFE AGTLYFIGVL 300
  301 IDHNNRITLY VDGSMINQLT LFENSICQLS TCELGSMICS IKVYRFYLWD GLLTEFAINI 360
  361 LQAIGTNYQY TFSKKKEGPE VLSLCQDFLI AKAHLMARPT TEISSTKYID EIELLEMENI 420
  421 IIDVNPNDIL QDFTESSNFT VKFEESTNSK NIPEVGKCYF YRSSNLVSKF VSIDSIRLAF 480
  481 LNMTESGSID DLFHHVSHLM NLLRNIDILN WFKKDFGFPL FAYTLKQKIT QDLSQPLNIQ 540
  541 FFNLFLEFCG WDFNDISKSI ILDTDAYENI VLNLDLWYMN EDQSSLASGG LEIIRFLFFQ 600
  601 ISSLMEASIY SKFNSNKFND MNILEKLCLS YQAVTKRENQ NSKFNELSSD LISVFVTLLK 660
  661 SNTDKRHLQW FLHLSYYFIK RKDVRSTEII LQAVDQLFSF YLDQGSDENA KILSEIIPLK 720
  721 LILMIMDQIV ENNESNPITC LNILFKVVLT NKPLFKQFYK NDGLKLILTM LCKVGKSYRE 780
  781 EIISLLLTYS IGNYTTANEI FSGAEDMIGG ISNDKITAKE IIYLAVNFIE WHVINSNASD 840
  841 SSSVLDLNNH ILRFVEDLKS LSAVPINESV FDPKKSYVMV SLLDLSIALN ESEDISKFKS 900
  901 SSKVISELIK GNIMCALTKY AAYDFEVYMS TFFCHSTEYK LVYPKTVMNN SSYLELSFIV 960
  961 TLLPEILNDL VDSNNNLNLM MLKHPYTMSN LLYFLRKFRP DTSQIVMPKD FYFSSYTCLL1020
 1021 HCVIQIDKSS FYHFKNVSKS QLLQDFKICI MNLIYSNTLK QIIWEKEEYE MFSESLMAHQ1080
 1081 EVLFAHGACD NETVGLLLIF FANRLRDCGY NKAVFNCMKV IIKNKERKLK EVACFFDPAN1140
 1141 KSEVLEGLSN ILSCNNSETM NLITEQYPFF FNNTQQVRFI NIVTNILFKN NNFSPISVRQ1200
 1201 IKNQVYEWKN ARSEYVTQNN KKCLILFRKD NTSLDFKIKK SISRYTYNLK TD

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [1253-1432]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 REENAVFYRN NLNLLIFHLK HTLEIQSNPN SSCKWSSDFA EDFDGMKRRL LPAWEPKYEP  60
   61 LINEEDANQD TITGGNRQRR ESGSILSYEF IEHMETLESE PVGDLNENRK ILRLLKDNDS 120
  121 IATIWNCSLI IGLEIKEGIL IHGSNYLYFV SDYYFSLEDK KILKLSEVSQ ESRDMTVSLI 180
  181 

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [1433-1522]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NGPDVKRVST FLKHEVFVWK LLDITFVTKR PFLLRDVAIE LLFKERVSAF FSFYNKRVRD  60
   61 DVLRVLNKIP KHLPADPIFS SVLQEINDRG 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [1523-1803]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NSIVARNGIG KASIASKFTS VFSANNSLID GFEISKKWVR GEISNFYYLL SINILAGRSF  60
   61 NDLTQYPVFP WVIADYESNV LDLENPKTYR DLSKPMGAQS EKRKLQFIER YEALASLENA 120
  121 DSAPFHYGTH YSSAMIVSSY LIRLKPFVES FLLLQGGSFG PADRLFSSLE RAWSSASSEN 180
  181 TTDVRELTPE FFFLPEFLIN VNSYDFGTDQ SGKKVDDVVL PPWANGDPKV FIQKNREALE 240
  241 SPYVSAHLHE WIDLIFGYKQ KGDIAVKSVN VFNRLSYPGA V

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 177.853872
Match: PF02138
Description: Beige/BEACH domain

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [1804-2167]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NLDNIDDENE RRAITGIIHN FGQTPLQIFQ EPHPEKIACN VQQLTTEVWR KVPMKPIFEK  60
   61 TIFNLNEKNR SVDYVIHDPS YFDSLYWRGF AFPNLFFRTE ESLVSLRIVH KNWLKIGLDI 120
  121 FKKTHMAQIT SFAYWKLGEF ITGDKNGLIK VWKYRKDKHS VSGNLENKKT MFGHLCELKE 180
  181 MRCYHDYNTL LTLDISGLVY VWDMINFELV RQITNDAQKV AISQHAGSIM VLTKNNAISI 240
  241 FNLNGQIYTS KKFEPAKIVS SIDFFDFTKL DAGYRKHIYW KEMEILLVGF EDGTIEIYEL 300
  301 FLNFHNEWAI KLLKQLCTEK GKAITSIKGQ GKTYLSQKRR KDTAEPHEIE VIAGTLDGRL 360
  361 AIWY

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 72.0
Match: 1gg2B_
Description: beta1-subunit of the signal-transducing G protein heterotrimer
Matching Structure (courtesy of the PDB):

Predicted Domain #6
Region A:
Residues: [1279-1366]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SNPNSSCKWS SDFAEDFDGM KRRLLPAWEP KYEPLINEED ANQDTITGGN RQRRESGSIL  60
   61 SYEFIEHMET LESEPVGDLN ENRKILRL

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #7
Region A:
Residues: [1367-1841]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LKDNDSIATI WNCSLIIGLE IKEGILIHGS NYLYFVSDYY FSLEDKKILK LSEVSQESRD  60
   61 MTVSLINGPD VKRVSTFLKH EVFVWKLLDI TFVTKRPFLL RDVAIELLFK ERVSAFFSFY 120
  121 NKRVRDDVLR VLNKIPKHLP ADPIFSSVLQ EINDRGNSIV ARNGIGKASI ASKFTSVFSA 180
  181 NNSLIDGFEI SKKWVRGEIS NFYYLLSINI LAGRSFNDLT QYPVFPWVIA DYESNVLDLE 240
  241 NPKTYRDLSK PMGAQSEKRK LQFIERYEAL ASLENADSAP FHYGTHYSSA MIVSSYLIRL 300
  301 KPFVESFLLL QGGSFGPADR LFSSLERAWS SASSENTTDV RELTPEFFFL PEFLINVNSY 360
  361 DFGTDQSGKK VDDVVLPPWA NGDPKVFIQK NREALESPYV SAHLHEWIDL IFGYKQKGDI 420
  421 AVKSVNVFNR LSYPGAVNLD NIDDENERRA ITGIIHNFGQ TPLQIFQEPH PEKIA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 167.0
Match: 1t77A
Description: Crystal structure of the PH-BEACH domains of human LRBA/BGL
Matching Structure (courtesy of the PDB):

Predicted Domain #8
Region A:
Residues: [1842-2167]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 CNVQQLTTEV WRKVPMKPIF EKTIFNLNEK NRSVDYVIHD PSYFDSLYWR GFAFPNLFFR  60
   61 TEESLVSLRI VHKNWLKIGL DIFKKTHMAQ ITSFAYWKLG EFITGDKNGL IKVWKYRKDK 120
  121 HSVSGNLENK KTMFGHLCEL KEMRCYHDYN TLLTLDISGL VYVWDMINFE LVRQITNDAQ 180
  181 KVAISQHAGS IMVLTKNNAI SIFNLNGQIY TSKKFEPAKI VSSIDFFDFT KLDAGYRKHI 240
  241 YWKEMEILLV GFEDGTIEIY ELFLNFHNEW AIKLLKQLCT EKGKAITSIK GQGKTYLSQK 300
  301 RRKDTAEPHE IEVIAGTLDG RLAIWY

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 71.30103
Match: 1p22A
Description: F-box/WD-repeat protein 1 (beta-TRCP1)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 1.8484919978091 bayes_pls_golite062009
protein binding 1.42618832381942 bayes_pls_golite062009
transporter activity 0.482752505032799 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle