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Protein Overview: NPP1

General Information:
Name(s) found: NPP1 / YCR026C [SGD]
Description(s) found:
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  • gi|32363486|sp|P25353.2|NPP1_YEAST RecName: Full=Ectonucleotide pyrophosphatase/phosphodiesterase 1; Short=E-NPP 1; Includes: RecName: Full=Alkaline phosphodiesterase 1; Includes: RecName: Full=Nucleotide pyrophosphatase; Short=NPPase [NCBI NR]
  • gi|14588938|emb|CAC42978.1| hypothetical protein [Saccharomyces cerevisiae] [NCBI NR]
  • gi|10383789|ref|NP_009955.2| Nucleotide pyrophosphatase/phosphodiesterase family member; mediates extracellular nucleotide phosphate hydrolysis along with Npp2p and Pho5p; activity and expression enhanced during conditions of phosphate starvation; Npp1p [ [NCBI NR]
  • (P25353) Uncharacterized protein YCR026C [Swiss-Prot]
  • Ectonucleotide pyrophosphatase/phosphodiesterase 1 OS=Saccharomyces cerevisiae GN=NPP1 PE=1 SV=2 [Swiss-Prot]
  • NPP1 Ecto-Nucleotide Pyrophosphatase/Phosphodiesterase [mips]
  • Nucleotide pyrophosphatase/phosphodiesterase family member; mediates extracellular nucleotide phosphate hydrolysis along with Npp2p and Pho5p; activity and expression enhanced during conditions of phosphate starvation [SGD]
  • YCR026C, Chr III from 164103-166331, reverse complement [yeast_orfs2]
  • Chr III from 164103-166331, reverse complement [yeastorf3.fasta]
  • Chr III from 166331-164103, reverse complement [yeastorf5.fasta]
  • (P25353) Hypothetical protein YCR026C [4932.FASTACCERV.txt]
  • YCR026C SGDID:S0000621, Chr III from 166334-164106, reverse complement, Uncharacterized ORF [yeastflysequest.fasta]
  • Ycr026cp [Saccharomyces cerevisiae]gi|14588938|emb|CAC42978.1| hypothetical protein [Saccharomyces cerevisiae]gi|32363486|sp|P25353|YCR6_YEAST Hypothetical protein YCR026C [nrdb_11152004_Chlamydomonas]
  • NPP1 SGDID:S000000621, Chr III from 166334-164106, reverse complement, Verified ORF, "Nucleotide pyrophosphatase/phosphodiesterase family member; mediates extracellular nucleotide phosphate hydrolysis along with Npp2p and Pho5p; activity and expression en [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • NPP1 SGDID:S000000621, Chr III from 166335-164107, reverse complement, Verified ORF, "Nucleotide pyrophosphatase/phosphodiesterase family member; mediates extracellular nucleotide phosphate hydrolysis along with Npp2p and Pho5p; activity and expression en [yeast-contam.fasta]
  • Nucleotide pyrophosphatase/phosphodiesterase family member; mediates extracellular nucleotide phosphate hydrolysis along with Npp2p and Pho5p; activity and expression enhanced during conditions of phosphate starvation; Npp1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • hypothetical protein [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Uncharacterized protein YCR026C [nr-271106-contam.fasta]
  • NPP1 SGDID:S000000621, Chr III from 166335-164107, reverse complement, Verified ORF, "Nucleotide pyrophosphatase/phosphodiesterase family member; mediates extracellular nucleotide phosphate hydrolysis along with Npp2p and Pho5p; activity and expression enhanced during conditions of phosphate starvation" [yeast-bovrabprots.fasta]
  • [chemostatdb.fasta]
  • Ectonucleotide pyrophosphatase/phosphodiesterase 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=NPP1 PE=1 SV=2 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • NPP1 SGDID:S000000621, Chr III from 166339-164111, Genome Release 64-1-1, reverse complement, Verified ORF, "Nucleotide pyrophosphatase/phosphodiesterase family member; mediates extracellular nucleotide phosphate hydrolysis along with Npp2p and Pho5p; activity and expression enhanced during conditions of phosphate starvation" [yeast-030211-contam.fasta]
  • NPP1 SGDID:S000000621, Chr III from 166339-164111, Genome Release 64-2-1, reverse complement, Verified ORF, "Nucleotide pyrophosphatase/phosphodiesterase; mediates extracellular nucleotide phosphate hydrolysis along with Npp2p and Pho5p; activity and expression enhanced during conditions of phosphate starvation; involved in spore wall assembly; NPP1 has a paralog, NPP2, that arose from the whole genome duplication, and an npp1 npp2 double mutant exhibits reduced dityrosine fluorescence relative to the single mutants" [20141208_orf_trans.fasta]
  • YCR026C SGDID:S000000621, Chr III from 166339-164111, Genome Release 64-1-1, reverse complement, Verified ORF, "Nucleotide pyrophosphatase/phosphodiesterase family member; mediates extracellular nucleotide phosphate hydrolysis along with Npp2p and Pho5p; activity and expression enhanced during conditions of phosphate starvation" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 742 amino acids

    Gene Ontology:
    Cellular Component: cellular_component [ND]
    Biological Process: cellular response to phosphate starvation [IEPLink to PubMed article][IMPLink to PubMed article]
    phosphate metabolic process [IMPLink to PubMed article][ISSLink to PubMed article]
    Molecular Function: phosphodiesterase I activity [ISSLink to PubMed article]
    nucleoside-triphosphatase activity [IGILink to PubMed article][IMPLink to PubMed article]
    nucleotide diphosphatase activity [ISSLink to PubMed article]
    nucleoside-triphosphate diphosphatase activity [IDALink to PubMed article][IGILink to PubMed article][IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MELQNDLESL DNELNDFSED PFRDDFITDE DAVRSGWRSA WTRMKYWFYK NRLKWTNNPI  60
   61 VIGDAKDSRD GSNFRRGIPL YELDANGQPI DTELVDENEL SFGTGFHSKV PFKIIFRTLF 120
  121 GSLVFAIFLI LMINIAKPHH STRVLSHFGS PEFDPYVKYF NGTHEFFPLT IVISLDGFHP 180
  181 SLISKRNTPF LHDLYELKYD GGMNITSTPF MVPSFPTETF PNHWTLVTGQ YPIHHGIVSN 240
  241 VFWDPDLNEE FHPGVLDPRI WNNNDTEPIW QTVQSAFDGD IPFKAATHMW PGSDVNYTKY 300
  301 NEEKLQPEHK NPIARERTPF YFDEFNAKEP LSQKLSKIIE YVDMSTLNER PQLILGYVPN 360
  361 VDAFGHKHGY PSESEYYYED FTETLGEVDT FLKQLVESLQ ERNLTSFTNL VIVSDHGMSD 420
  421 IVVPSNVIIW EDLLDEKLRK DYVSHAYLEG PMMAISLKDS GNINEVYHNL KTSIDEDKYT 480
  481 VYVNGNFPKE WNFNDGKNHH MASIWIVPEP GYAVMKKEQL KKVAKGDHKD KNEDNVFTIG 540
  541 SHGYDNNAID MRSVFIGMGP YFPQGYIEPF QNTEIYNLLC DICGVAEKDR NSNDGTGMLM 600
  601 NQLREPQSSE EVEIEDDFDY LVSKFGEFST YNIIWGGYPE ETEQDNVDND NDDNDDGNTD 660
  661 EIAAMPSSSL TIKLEMTTSI PSATETLLGE TSPSSRSSSS SSIQASATAS TVGDWLQDII 720
  721 NDAKDLIDDI IDSIDDLVDS DT

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #31 Asynchronous Prep (Protease cleavage) Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..136] MSA 1.02296 View MSA. No confident structure predictions are available.
    2 View Details [137..493] PSI-BLAST 38.221849 Arylsulfatase A
    3 View Details [494..550] deduced N/A No confident structure predictions are available.
    4 View Details [551..636] MSA 4.068989 View MSA. No confident structure predictions are available.
    5 View Details [637..742] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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