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View Structure Prediction Details

Protein: NPP1
Organism: Saccharomyces cerevisiae
Length: 742 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for NPP1.

Description E-value Query
Range
Subject
Range
NPP1_YEAST - Ectonucleotide pyrophosphatase/phosphodiesterase 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 /...
NPP1 - Nucleotide pyrophosphatase/phosphodiesterase family member; mediates extracellular nucleotide phosph...
0.0 [1..742] [1..742]
gi|16588834 - gi|16588834|gb|AAL26912.1| ecto-nucleotide pyrophosphatase [Rattus norvegicus]
4.0E-89 [156..616] [180..594]
ENPP3 - ectonucleotide pyrophosphatase/phosphodiesterase 3
2.0E-88 [144..616] [132..560]
gi|148672837, gi... - gi|15099945|gb|AAK84174.1|AF339910_1 ectonucleotide pyrophosphatase/phosphodiesterase 1 allotype b [...
2.0E-88 [156..616] [180..594]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
3.0E-88 [156..616] [180..594]

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Predicted Domain #1
Region A:
Residues: [1-136]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MELQNDLESL DNELNDFSED PFRDDFITDE DAVRSGWRSA WTRMKYWFYK NRLKWTNNPI  60
   61 VIGDAKDSRD GSNFRRGIPL YELDANGQPI DTELVDENEL SFGTGFHSKV PFKIIFRTLF 120
  121 GSLVFAIFLI LMINIA

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [137-493]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KPHHSTRVLS HFGSPEFDPY VKYFNGTHEF FPLTIVISLD GFHPSLISKR NTPFLHDLYE  60
   61 LKYDGGMNIT STPFMVPSFP TETFPNHWTL VTGQYPIHHG IVSNVFWDPD LNEEFHPGVL 120
  121 DPRIWNNNDT EPIWQTVQSA FDGDIPFKAA THMWPGSDVN YTKYNEEKLQ PEHKNPIARE 180
  181 RTPFYFDEFN AKEPLSQKLS KIIEYVDMST LNERPQLILG YVPNVDAFGH KHGYPSESEY 240
  241 YYEDFTETLG EVDTFLKQLV ESLQERNLTS FTNLVIVSDH GMSDIVVPSN VIIWEDLLDE 300
  301 KLRKDYVSHA YLEGPMMAIS LKDSGNINEV YHNLKTSIDE DKYTVYVNGN FPKEWNF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 38.221849
Match: 1e1zP_
Description: Arylsulfatase A
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [494-550]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NDGKNHHMAS IWIVPEPGYA VMKKEQLKKV AKGDHKDKNE DNVFTIGSHG YDNNAID

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [551-636]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRSVFIGMGP YFPQGYIEPF QNTEIYNLLC DICGVAEKDR NSNDGTGMLM NQLREPQSSE  60
   61 EVEIEDDFDY LVSKFGEFST YNIIWG

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [637-742]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GYPEETEQDN VDNDNDDNDD GNTDEIAAMP SSSLTIKLEM TTSIPSATET LLGETSPSSR  60
   61 SSSSSSIQAS ATASTVGDWL QDIINDAKDL IDDIIDSIDD LVDSDT

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle