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Protein Overview: APE3

General Information:
Name(s) found: APE3 / YBR286W [SGD]
Description(s) found:
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  • ref|NP_009845.1| Ape3p [Saccharomyces cerevisiae] [NCBI NR]
  • Vacuolar aminopeptidase Y, processed to mature form by Prb1p [SGD]
  • APE3, Chr II from 774579-776270 [yeast_orfs2]
  • Chr II from 774579-776270 [yeastorf3.fasta]
  • Chr II from 774578-776269 [yeastorf4.fasta]
  • Chr II from 774576-776267 [yeastorf5.fasta]
  • APE3 SGDID:S0000490, Chr II from 774580-776271, Verified ORF [yeastflysequest.fasta]
  • APE3 SGDID:S0000490, Chr II from 774618-776309, Verified ORF [10112005cervSGD.fasta]
  • Ape3p [Saccharomyces cerevisiae] [nrdb_11152004_Chlamydomonas]
    • Organism: Saccharomyces cerevisiae
    Length: 563 amino acids

    Gene Ontology:
    Cellular Component: fungal-type vacuole [IDALink to PubMed article]
    Biological Process: telomere maintenance [IMPLink to PubMed article]
    vacuolar protein catabolic process [IDALink to PubMed article]
    Molecular Function: aminopeptidase activity [IDALink to PubMed article][IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGTKPCSAFQ QLVEEAKKKK KTETPTMHFS LKQLAVAAFY ATNLGSAYVI PQFFQEAFQQ  60
   61 EEPIENYLPQ LNDDDSSAVA ANIPKPHIPY FMKPHVESEK LQDKIKVDDL NATAWDLYRL 120
  121 ANYSTPDYGH PTRVIGSKGH NKTMEYILNV FDDMQDYYDV SLQEFEALSG KIISFNLSDA 180
  181 ETGKSFANTT AFALSPPVDG FVGKLVEIPN LGCEEKDYAS VVPPRHNEKQ IALIERGKCP 240
  241 FGDKSNLAGK FGFTAVVIYD NEPKSKEGLH GTLGEPTKHT VATVGVPYKV GKKLIANIAL 300
  301 NIDYSLYFAM DSYVEFIKTQ NIIADTKHGD PDNIVALGAH SDSVEEGPGI NDDGSGTISL 360
  361 LNVAKQLTHF KINNKVRFAW WAAEEEGLLG SNFYAYNLTK EENSKIRVFM DYDMMASPNY 420
  421 EYEIYDANNK ENPKGSEELK NLYVDYYKAH HLNYTLVPFD GRSDYVGFIN NGIPAGGIAT 480
  481 GAEKNNVNNG KVLDRCYHQL CDDVSNLSWD AFITNTKLIA HSVATYADSF EGFPKRETQK 540
  541 HKEVDILNAQ QPQFKYRADF LII

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..195] MSA 1.118986 View MSA. No confident structure predictions are available.
    2 View Details [196..319] Pfam 16.040959 No description for PF02225.8 was found. No confident structure predictions are available.
    3 View Details [320..563] PSI-BLAST 31.30103 Aminopeptidase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • peptidase activity
    		•  4.69852272549237 bayes_pls_golite062009
  • hydrolase activity
    		•  4.23257784904124 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  4.21193944512431 bayes_pls_golite062009
  • exopeptidase activity
    		•  1.5759162922092 bayes_pls_golite062009
  • catalytic activity
    		•  1.3989281287879 bayes_pls_golite062009
  • metallopeptidase activity
    		•  1.13008914743741 bayes_pls_golite062009
  • carboxypeptidase activity
    		•  0.891655769761122 bayes_pls_golite062009
  • metalloexopeptidase activity
    		•  0.472688733072762 bayes_pls_golite062009
  • endopeptidase activity
    		•  0.444575216242393 bayes_pls_golite062009
  • binding
    		•  0.306621556591446 bayes_pls_golite062009
  • metallocarboxypeptidase activity
    		•  0.180859448845431 bayes_pls_golite062009
  • aminopeptidase activity
    		•  0.0966237570696103 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle