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View Structure Prediction Details

Protein: APE3
Organism: Saccharomyces cerevisiae
Length: 563 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for APE3.

Description E-value Query
Range
Subject
Range
APE3 - Vacuolar aminopeptidase Y, processed to mature form by Prb1p
APE3_YEAST - Aminopeptidase Y OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=APE3 PE=1 SV=1
0.0 [27..563] [1..537]
gi|44982813, gi|... - gi|45187996|ref|NP_984219.1| ADR123Wp [Ashbya gossypii ATCC 10895], gi|44982813|gb|AAS52043.1| ADR12...
gi|44982813 - gi|44982813|gb|AAS52043.1| ADR123Wp [Ashbya gossypii ATCC 10895]
2.0E-79 [47..562] [16..519]
TFR1_MOUSE - Transferrin receptor protein 1 OS=Mus musculus GN=Tfrc PE=1 SV=1
5.0E-74 [18..554] [55..624]
gi|46124299, gi|... - gi|46124299|ref|XP_386703.1| hypothetical protein FG06527.1 [Gibberella zeae PH-1], gi|42555469|gb|E...
2.0E-73 [60..563] [4..510]
gi|68483206, gi|... - gi|68483206|ref|XP_714438.1| hypothetical protein CaO19.3591 [Candida albicans SC5314], gi|46436001|...
orf19.3591 - APE3 CGDID:CAL0006018 Assembly 19, Contig19-10184 (7249, 8901) CDS, translated using codon table 12 ...
2.0E-72 [64..563] [50..550]
TFR1_FELCA - Transferrin receptor protein 1 OS=Felis catus GN=TFRC PE=1 SV=1
6.0E-70 [18..555] [58..631]
TFR1_CANLF - Transferrin receptor protein 1 OS=Canis lupus familiaris GN=TFRC PE=1 SV=1
3.0E-69 [18..555] [58..632]
TFRC - transferrin receptor (p90, CD71)
4.0E-69 [19..555] [56..622]
TFR1_CRIGR - Transferrin receptor protein 1 OS=Cricetulus griseus GN=TFRC PE=2 SV=1
7.0E-69 [18..555] [55..619]

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Predicted Domain #1
Region A:
Residues: [1-195]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGTKPCSAFQ QLVEEAKKKK KTETPTMHFS LKQLAVAAFY ATNLGSAYVI PQFFQEAFQQ  60
   61 EEPIENYLPQ LNDDDSSAVA ANIPKPHIPY FMKPHVESEK LQDKIKVDDL NATAWDLYRL 120
  121 ANYSTPDYGH PTRVIGSKGH NKTMEYILNV FDDMQDYYDV SLQEFEALSG KIISFNLSDA 180
  181 ETGKSFANTT AFALS

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [196-319]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PPVDGFVGKL VEIPNLGCEE KDYASVVPPR HNEKQIALIE RGKCPFGDKS NLAGKFGFTA  60
   61 VVIYDNEPKS KEGLHGTLGE PTKHTVATVG VPYKVGKKLI ANIALNIDYS LYFAMDSYVE 120
  121 FIKT

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 16.040959
Match: PF02225.8
Description: No description for PF02225.8 was found.

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [320-563]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QNIIADTKHG DPDNIVALGA HSDSVEEGPG INDDGSGTIS LLNVAKQLTH FKINNKVRFA  60
   61 WWAAEEEGLL GSNFYAYNLT KEENSKIRVF MDYDMMASPN YEYEIYDANN KENPKGSEEL 120
  121 KNLYVDYYKA HHLNYTLVPF DGRSDYVGFI NNGIPAGGIA TGAEKNNVNN GKVLDRCYHQ 180
  181 LCDDVSNLSW DAFITNTKLI AHSVATYADS FEGFPKRETQ KHKEVDILNA QQPQFKYRAD 240
  241 FLII

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 31.30103
Match: 1cp7A_
Description: Aminopeptidase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
peptidase activity 4.69852272549237 bayes_pls_golite062009
hydrolase activity 4.23257784904124 bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides 4.21193944512431 bayes_pls_golite062009
exopeptidase activity 1.5759162922092 bayes_pls_golite062009
catalytic activity 1.3989281287879 bayes_pls_golite062009
metallopeptidase activity 1.13008914743741 bayes_pls_golite062009
carboxypeptidase activity 0.891655769761122 bayes_pls_golite062009
metalloexopeptidase activity 0.472688733072762 bayes_pls_golite062009
endopeptidase activity 0.444575216242393 bayes_pls_golite062009
binding 0.306621556591446 bayes_pls_golite062009
metallocarboxypeptidase activity 0.180859448845431 bayes_pls_golite062009
aminopeptidase activity 0.0966237570696103 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle