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Protein Overview: ABD1

General Information:
Name(s) found: ABD1 / YBR236C [SGD]
Description(s) found:
Found 26 descriptions.
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  • Methyltransferase, catalyzes the transfer of a methyl group from S-adenosylmethionine to the GpppN terminus of capped mRNA [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 436 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IPILink to PubMed article]
    DNA-directed RNA polymerase II, holoenzyme [IPILink to PubMed article]
    Biological Process: mRNA capping [IDALink to PubMed article]
    Molecular Function: mRNA (guanine-N7-)-methyltransferase activity [IDALink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSTKPEKPIW MSQEDYDRQY GSITGDESST VSKKDSKVTA NAPGDGNGSL PVLQSSSILT  60
   61 SKVSDLPIEA ESGFKIQKRR HERYDQEERL RKQRAQKLRE EQLKRHEIEM TANRSINVDQ 120
  121 IVREHYNERT IIANRAKRNL SPIIKLRNFN NAIKYMLIDK YTKPGDVVLE LGCGKGGDLR 180
  181 KYGAAGISQF IGIDISNASI QEAHKRYRSM RNLDYQVVLI TGDCFGESLG VAVEPFPDCR 240
  241 FPCDIVSTQF CLHYAFETEE KARRALLNVA KSLKIGGHFF GTIPDSEFIR YKLNKFPKEV 300
  301 EKPSWGNSIY KVTFENNSYQ KNDYEFTSPY GQMYTYWLED AIDNVPEYVV PFETLRSLAD 360
  361 EYGLELVSQM PFNKFFVQEI PKWIERFSPK MREGLQRSDG RYGVEGDEKE AASYFYTMFA 420
  421 FRKVKQYIEP ESVKPN

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Gavin AC, et al. (2002) ABD1 AOS1 IWR1 RPB11 RPB2 RPB3 RPB4 RPB5 RPB7 RPB8 RPB9 RPO21 RPO26 SPT4 SPT5 TAF14 TFG1 TFG2

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #11 Mitotic Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen CTF13 ABD1 1 Unpublished Fields Lab Data
    View Screen NAF1 ABD1 1 Hazbun TR, et al. (2003)

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data ABD1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..94] deduced N/A No confident structure predictions are available.
    2 View Details [95..147]
    [288..347]    		 PSI-BLAST 1760.522879 No description for 1ic3A_ was found.
    3 View Details [148..287]
    [348..436]    		 PSI-BLAST 1760.522879 No description for 1ic3A_ was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • mRNA (guanine-N7-)-methyltransferase activity
    		•  4.23788594273427 bayes_pls_golite062009
  • mRNA methyltransferase activity
    		•  4.23788594273427 bayes_pls_golite062009
  • S-adenosylmethionine-dependent methyltransferase activity
    		•  2.50181720310228 bayes_pls_golite062009
  • methyltransferase activity
    		•  2.39031546273566 bayes_pls_golite062009
  • transferase activity, transferring one-carbon groups
    		•  2.30769384783609 bayes_pls_golite062009
  • N-methyltransferase activity
    		•  2.26670816231281 bayes_pls_golite062009
  • RNA methyltransferase activity
    		•  1.86200407013263 bayes_pls_golite062009
  • rRNA methyltransferase activity
    		•  1.3386061065513 bayes_pls_golite062009
  • catalytic activity
    		•  1.25333584501255 bayes_pls_golite062009
  • RNA binding
    		•  1.10729923226801 bayes_pls_golite062009
  • transferase activity
    		•  1.07321114919891 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.914549843668268 bayes_pls_golite062009
  • tRNA methyltransferase activity
    		•  0.868107614027708 bayes_pls_golite062009
  • DNA binding
    		•  0.86027591375666 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.616949327277483 bayes_pls_golite062009
  • binding
    		•  0.383237930789959 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle