YRC Public Data Repository - Protein Structure Prediction

Protein:	ABD1
Organism:	Saccharomyces cerevisiae
Length:	436 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ABD1.

Description	E-value	Query Range	Subject Range
ABD1 - Methyltransferase, catalyzes the transfer of a methyl group from S-adenosylmethionine to the GpppN t... MCES_YEAST - mRNA cap guanine-N7 methyltransferase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=AB... gi\|151946622 - gi\|151946622\|gb\|EDN64844.1\| RNA (guanine-7-)methyltransferase [Saccharomyces cerevisiae YJM789]	0.0	[1..436]	[1..436]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	2.0E-52	[69..427]	[2..344]
gi\|3560474 - gi\|3560474\|gb\|AAC34951.1\| S-adenosyl-methionine-sterol-C- methyltransferase [Nicotiana tabacum]	4.0E-52	[69..427]	[2..344]
gi\|3560531 - gi\|3560531\|gb\|AAC34988.1\| cycloartenol-C24-methyltransferase [Oryza sativa subsp. japonica]	1.0E-51	[69..427]	[2..349]
gi\|15150518, gi\|... - gi\|22595614\|gb\|AAN02647.1\| mRNA capping enzyme large subunit [lumpy skin disease virus], gi\|15150518... gi\|15150518, gi\|... - gi\|15150518\|ref\|NP_150513.1\| LSDV079 mRNA capping enzyme large subunit [Lumpy skin disease virus NI-... gi\|22595614 - gi\|22595614\|gb\|AAN02647.1\| mRNA capping enzyme large subunit [Lumpy skin disease virus NW-LW]	2.0E-50	[35..423]	[460..841]
MCES_MOUSE - mRNA cap guanine-N7 methyltransferase OS=Mus musculus GN=Rnmt PE=1 SV=1	2.0E-49	[58..423]	[76..463]
gi\|170664715 - gi\|170664715\|gb\|ACB28871.1\| m76R [recombinant virus 6918VP60-T2] gi\|6523931, gi\|1... - gi\|9633712\|ref\|NP_051790.1\| m76R [Myxoma virus], gi\|6523931\|gb\|AAF14964.1\|AF170726_80 m76R [Myxoma v...	4.0E-49	[35..423]	[453..834]
MCEL_VACCC - mRNA-capping enzyme catalytic subunit OS=Vaccinia virus (strain Copenhagen) GN=D1R PE=3 SV=1 gi\|9791031, gi\|7... - gi\|9791031\|ref\|NP_063758.1\| mRNA capping enzyme, large subunit [Vaccinia virus], gi\|74315\|pir\|\|QQVZV...	7.0E-49	[35..423]	[460..843]

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Predicted Domain #1

Region A:
Residues: [1-94]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSTKPEKPIW MSQEDYDRQY GSITGDESST VSKKDSKVTA NAPGDGNGSL PVLQSSSILT  60
   61 SKVSDLPIEA ESGFKIQKRR HERYDQEERL RKQR

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [95-147]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AQKLREEQLK RHEIEMTANR SINVDQIVRE HYNERTIIAN RAKRNLSPII KLR

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [288-347]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FIRYKLNKFP KEVEKPSWGN SIYKVTFENN SYQKNDYEFT SPYGQMYTYW LEDAIDNVPE  60
   61

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1760.522879
Match:	1ic3A_
Description:	No description for 1ic3A_ was found.

Predicted functions:

Term	Confidence	Notes
mRNA (guanine-N7-)-methyltransferase activity	4.23788594273427	bayes_pls_golite062009
mRNA methyltransferase activity	4.23788594273427	bayes_pls_golite062009
S-adenosylmethionine-dependent methyltransferase activity	2.50181720310228	bayes_pls_golite062009
methyltransferase activity	2.39031546273566	bayes_pls_golite062009
transferase activity, transferring one-carbon groups	2.30769384783609	bayes_pls_golite062009
N-methyltransferase activity	2.26670816231281	bayes_pls_golite062009
RNA methyltransferase activity	1.86200407013263	bayes_pls_golite062009
rRNA methyltransferase activity	1.3386061065513	bayes_pls_golite062009
catalytic activity	1.25333584501255	bayes_pls_golite062009
RNA binding	1.10729923226801	bayes_pls_golite062009
transferase activity	1.07321114919891	bayes_pls_golite062009
transcription regulator activity	0.914549843668268	bayes_pls_golite062009
tRNA methyltransferase activity	0.868107614027708	bayes_pls_golite062009
DNA binding	0.86027591375666	bayes_pls_golite062009
nucleic acid binding	0.616949327277483	bayes_pls_golite062009
binding	0.383237930789959	bayes_pls_golite062009

Predicted Domain #3

Region A:
Residues: [148-287]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NFNNAIKYML IDKYTKPGDV VLELGCGKGG DLRKYGAAGI SQFIGIDISN ASIQEAHKRY  60
   61 RSMRNLDYQV VLITGDCFGE SLGVAVEPFP DCRFPCDIVS TQFCLHYAFE TEEKARRALL 120
  121 NVAKSLKIGG HFFGTIPDSE

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [348-436]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YVVPFETLRS LADEYGLELV SQMPFNKFFV QEIPKWIERF SPKMREGLQR SDGRYGVEGD  60
   61 EKEAASYFYT MFAFRKVKQY IEPESVKPN

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1760.522879
Match:	1ic3A_
Description:	No description for 1ic3A_ was found.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: