YRC Public Data Repository - Protein Structure Prediction

Protein:	ABD1
Organism:	Saccharomyces cerevisiae
Length:	436 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ABD1.

Description	E-value	Query Range	Subject Range
ABD1 - Methyltransferase, catalyzes the transfer of a methyl group from S-adenosylmethionine to the GpppN t... MCES_YEAST - mRNA cap guanine-N7 methyltransferase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=AB... gi\|151946622 - gi\|151946622\|gb\|EDN64844.1\| RNA (guanine-7-)methyltransferase [Saccharomyces cerevisiae YJM789]	0.0	[1..436]	[1..436]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	2.0E-52	[69..427]	[2..344]
gi\|3560474 - gi\|3560474\|gb\|AAC34951.1\| S-adenosyl-methionine-sterol-C- methyltransferase [Nicotiana tabacum]	4.0E-52	[69..427]	[2..344]
gi\|3560531 - gi\|3560531\|gb\|AAC34988.1\| cycloartenol-C24-methyltransferase [Oryza sativa subsp. japonica]	1.0E-51	[69..427]	[2..349]
gi\|15150518, gi\|... - gi\|22595614\|gb\|AAN02647.1\| mRNA capping enzyme large subunit [lumpy skin disease virus], gi\|15150518... gi\|15150518, gi\|... - gi\|15150518\|ref\|NP_150513.1\| LSDV079 mRNA capping enzyme large subunit [Lumpy skin disease virus NI-... gi\|22595614 - gi\|22595614\|gb\|AAN02647.1\| mRNA capping enzyme large subunit [Lumpy skin disease virus NW-LW]	2.0E-50	[35..423]	[460..841]
MCES_MOUSE - mRNA cap guanine-N7 methyltransferase OS=Mus musculus GN=Rnmt PE=1 SV=1	2.0E-49	[58..423]	[76..463]
gi\|170664715 - gi\|170664715\|gb\|ACB28871.1\| m76R [recombinant virus 6918VP60-T2] gi\|6523931, gi\|1... - gi\|9633712\|ref\|NP_051790.1\| m76R [Myxoma virus], gi\|6523931\|gb\|AAF14964.1\|AF170726_80 m76R [Myxoma v...	4.0E-49	[35..423]	[453..834]
MCEL_VACCC - mRNA-capping enzyme catalytic subunit OS=Vaccinia virus (strain Copenhagen) GN=D1R PE=3 SV=1 gi\|9791031, gi\|7... - gi\|9791031\|ref\|NP_063758.1\| mRNA capping enzyme, large subunit [Vaccinia virus], gi\|74315\|pir\|\|QQVZV...	7.0E-49	[35..423]	[460..843]

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Predicted Domain #1

Region A:
Residues: [1-94]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSTKPEKPIW MSQEDYDRQY GSITGDESST VSKKDSKVTA NAPGDGNGSL PVLQSSSILT  60
   61 SKVSDLPIEA ESGFKIQKRR HERYDQEERL RKQR

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

		MCM Score	SCOP Match	SCOP Description
View	Download	0.237	a.60.8	HRDC-like
View	Download	0.290	b.34.8	Fumarylacetoacetate hydrolase, FAH, N-terminal domain

Predicted Domain #2

Region A:
Residues: [95-147]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AQKLREEQLK RHEIEMTANR SINVDQIVRE HYNERTIIAN RAKRNLSPII KLR

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [288-347]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FIRYKLNKFP KEVEKPSWGN SIYKVTFENN SYQKNDYEFT SPYGQMYTYW LEDAIDNVPE  60
   61

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1760.522879
Match:	1ic3A_
Description:	No description for 1ic3A_ was found.

Predicted functions:

Term	Confidence	Notes
mRNA (guanine-N7-)-methyltransferase activity	4.23788594273427	bayes_pls_golite062009
mRNA methyltransferase activity	4.23788594273427	bayes_pls_golite062009
S-adenosylmethionine-dependent methyltransferase activity	2.50181720310228	bayes_pls_golite062009
methyltransferase activity	2.39031546273566	bayes_pls_golite062009
transferase activity, transferring one-carbon groups	2.30769384783609	bayes_pls_golite062009
N-methyltransferase activity	2.26670816231281	bayes_pls_golite062009
RNA methyltransferase activity	1.86200407013263	bayes_pls_golite062009
rRNA methyltransferase activity	1.3386061065513	bayes_pls_golite062009
catalytic activity	1.25333584501255	bayes_pls_golite062009
RNA binding	1.10729923226801	bayes_pls_golite062009
transferase activity	1.07321114919891	bayes_pls_golite062009
transcription regulator activity	0.914549843668268	bayes_pls_golite062009
tRNA methyltransferase activity	0.868107614027708	bayes_pls_golite062009
DNA binding	0.86027591375666	bayes_pls_golite062009
nucleic acid binding	0.616949327277483	bayes_pls_golite062009
binding	0.383237930789959	bayes_pls_golite062009

Predicted Domain #3

Region A:
Residues: [148-287]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NFNNAIKYML IDKYTKPGDV VLELGCGKGG DLRKYGAAGI SQFIGIDISN ASIQEAHKRY  60
   61 RSMRNLDYQV VLITGDCFGE SLGVAVEPFP DCRFPCDIVS TQFCLHYAFE TEEKARRALL 120
  121 NVAKSLKIGG HFFGTIPDSE

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [348-436]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YVVPFETLRS LADEYGLELV SQMPFNKFFV QEIPKWIERF SPKMREGLQR SDGRYGVEGD  60
   61 EKEAASYFYT MFAFRKVKQY IEPESVKPN

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1760.522879
Match:	1ic3A_
Description:	No description for 1ic3A_ was found.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: