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Protein Overview: COS111

General Information:
Name(s) found: COS111 / YBR203W [SGD]
Description(s) found:
Found 25 descriptions.
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  • Protein required for resistance to the antifungal drug ciclopirox olamine; not related to the subtelomerically-encoded COS family; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 924 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [IDALink to PubMed article]
    Biological Process: signal transduction [IMPLink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSASRLQNV NIVSNNYSRY GTSVYDKLYH SNGSGSNNAG KNSTTVGKLS SISQKSRSKQ  60
   61 RHGSNCSRSM SQSPLSTFKS PLSNQNQSSA PDDLASIGQR RSDDVTSLDN ETIITMNSRK 120
  121 SRIKKKYKSL ISTSSKKFMN KLYDHGASSD SFSIFSLKTS HSGKHENSRF EKLRKRKYHA 180
  181 WGKFADINDL PVEIIAKILS EFELGRDQKT LVRCLYVSKK FYKATKIVLY RLPYFTSTYR 240
  241 VAQFVTSLRL HPDNGAYVKV LDLSHLKPGI IGQDSKDSQG LDDDGHSRRH RRRRRRSTNT 300
  301 SLNLPPATPT STISNEDDAN SGLIKDDASN GSEVEDLALA GWRDWRYRNE PLYSSPLLNS 360
  361 FKLKKVVSRS SSITSTSSGN STGVHSTRRQ RSNSSVASIT TSIMSSIYNT SHVSLSSTTS 420
  421 NTSNGNISSG SNLSRVSTAG SLKKASAKST RSSPQKAKPI SDITSSSWFR MRLSSRNRKA 480
  481 RTANTINLKN SKDKSDDDFK VLKHDSGHPS NYRSSTLKFS IEQPFSTHHP YANKFLLKYA 540
  541 PYKDLPLGYI LHMLNLCPNL VELNLSNLVI CTDFKLINQR SERRRMTSSL LPAVQESSVS 600
  601 AGPEKDLEIV YMTDSGKGYE YYEGLSKKHS RSSSLGTNPS SWIGGQANWT DYPPPIDAQT 660
  661 KTREEHRRNN TLNNKNVVLK KLNPFEIFEM ICNRNEEKGG YCSLTKVKMN DIVWCRQYMV 720
  721 KYFVMRSWRN DLDYKSMENN SYERHLFSFR DSGLDRNFSW ACNAKLHEFV ALMVMDHLSN 780
  781 LDDLGLEELF NIKSEKLYIK NYCCRDPDIL EISNLFDIRY GAGSEADATS DSNLEAESLQ 840
  841 FRLTILKTEK PTSFWLTKVS KDYVSLVVKL CVDDDIDMDK MKVGKPTLRI DSITHNLISR 900
  901 LKELRRVDLR RNVGENSYYA GSII

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Ho Y, et al. (2002) COS111 NAP1 SKP1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #13 Mitotic Prep2-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #11 Mitotic Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..184] deduced N/A No confident structure predictions are available.
    2 View Details [185..297] Pfam 2.638272 F-box domain Confident ab initio structure predictions are available.
    3 View Details [298..924] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle