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Protein Overview: ALK2

General Information:
Name(s) found: ALK2 / YBL009W [SGD]
Description(s) found:
Found 26 descriptions.
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  • Protein kinase; accumulation and phosphorylation are periodic during the cell cycle; phosphorylated in response to DNA damage; contains characteristic motifs for degradation via the APC pathway; similar to Alk1p and to mammalian haspins [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 676 amino acids

    Gene Ontology:
    Cellular Component: cellular_component [ND]
    Biological Process: mitosis [IEPLink to PubMed article][IMPLink to PubMed article]
    protein amino acid phosphorylation [IDALink to PubMed article]
    meiosis [IEPLink to PubMed article]
    Molecular Function: protein kinase activity [IDALink to PubMed article]
    protein serine/threonine kinase activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNFDAVADQQ MTDRRYFALE VAESDDADSS LNSSSMGSPA VDVGRKVYKI TSHKGSAEDE  60
   61 SQSFFTSSDS PTSKTRPVGK TIENDDYYGK RSSTGSSLKQ LFNKININDT AHSSNKENVS 120
  121 QSVLSENKLL SPSKRLSKQG LTKVTNSKFR TPLRPISNQS TLSRDEPVKD FRSLKFRSGS 180
  181 DFKCWGDEKT SSHVHSSSVN SVNSFTSTTS SSKWKFWKND NLLSRSLSSR SVNDQDPNFV 240
  241 QPKPTNSLQK KSSISSFHNS IFGGGKHTEK KRNSGFIMPD HQSTKELNHK HSSSNLSFRS 300
  301 LKHKTSHSSL NKLKVRRKGN TQELNHPIKK TCQISLPVPD QVSKDKIQLK LKNSTSLASL 360
  361 SSEVTPINTL DYNDSILQQI LQLCDVKYIL HDLREAQSLG LFTLNTRSVQ LSHNFWQTYH 420
  421 SDMQTSLICK KVCLGALSDL TTSNLISLHE LKSLRLIQGT SGVANLLQAY VVPSNQCEND 480
  481 QNLILYLFFK YQGTPLSRCS NIDYSQALSI FWQCSSILYV AESKFQLEHR NLTLDHILID 540
  541 SKGNVTLIDM KCCRFLNIDN NKASYTRLDH HYFFQGRGTL QFEIYELMRS MLPQPISWAT 600
  601 FEPRTNLLWL YHLSSSLLKM AKKAVVSGAL NREENILIEL THLLDPARKH SKTIFKKELV 660
  661 IRTCGDLLSL KGEIMQ

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run ZDS1 Sample 3 - cpn + atp, from june 2005 McCusker D, et al (2007)
    View Run MLP2 #25 Asynchronous Prep3-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #21 Asynchronous Prep2-IMAC Phosphopeptide enrichment A1 Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..368] deduced N/A No confident structure predictions are available.
    2 View Details [369..489] PSI-BLAST 101.0 Cyclin-dependent PK, CDK2
    3 View Details [490..561] PSI-BLAST 101.0 Cyclin-dependent PK, CDK2
    4 View Details [562..612] PSI-BLAST 101.0 Cyclin-dependent PK, CDK2
    5 View Details [613..676] PSI-BLAST 101.0 Cyclin-dependent PK, CDK2

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • protein kinase activity
    		•  5.08693983533348 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  4.80278598786839 bayes_pls_golite062009
  • kinase activity
    		•  4.59756610116144 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  4.25355168820731 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  4.23864440079487 bayes_pls_golite062009
  • transferase activity
    		•  3.26787750561728 bayes_pls_golite062009
  • ATP binding
    		•  1.87003701072722 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  1.82650528610717 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  1.79644024762454 bayes_pls_golite062009
  • binding
    		•  1.69939147712641 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  1.56978145564551 bayes_pls_golite062009
  • ribonucleotide binding
    		•  1.56956819263374 bayes_pls_golite062009
  • purine nucleotide binding
    		•  1.54471996792105 bayes_pls_golite062009
  • nucleotide binding
    		•  1.53595022832543 bayes_pls_golite062009
  • catalytic activity
    		•  1.21655087018101 bayes_pls_golite062009
  • protein binding
    		•  1.17747188575743 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  1.17063753242103 bayes_pls_golite062009
  • receptor signaling protein serine/threonine kinase activity
    		•  1.05410128646972 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  0.98751004123886 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  0.439470338563384 bayes_pls_golite062009
  • magnesium ion binding
    		•  0.0936583701619971 bayes_pls_golite062009
    4 No functions predicted.
    5 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle