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Protein Overview: BDH1

General Information:
Name(s) found: BDH1 / YAL060W [SGD]
Description(s) found:
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  • gi|731293|sp|P39714.1|BDH1_YEAST RecName: Full=(R,R)-butanediol dehydrogenase [NCBI NR]
  • gi|6319258|ref|NP_009341.1| NAD-dependent (R,R)-butanediol dehydrogenase, catalyzes oxidation of (R,R)-2,3-butanediol to (3R)-acetoin, oxidation of meso-butanediol to (3S)-acetoin, and reduction of acetoin; enhances use of 2,3-butanediol as an aerobic car [NCBI NR]
  • gi|595526|gb|AAC04974.1| Yal060wp [Saccharomyces cerevisiae] [NCBI NR]
  • pir||S51962 FUN49 protein - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • (R,R)-butanediol dehydrogenase OS=Saccharomyces cerevisiae GN=BDH1 PE=1 SV=1 [Swiss-Prot]
  • BDH1 Stereospecific (2R, 3R)-2,3-butanediol dehydrogenase [mips]
  • NAD-dependent (R,R)-butanediol dehydrogenase, catalyzes oxidation of (R,R)-2,3-butanediol to (3R)-acetoin, oxidation of meso-butanediol to (3S)-acetoin, and reduction of acetoin; enhances use of 2,3-butanediol as an aerobic carbon source [SGD]
  • YAL060W, Chr I from 35156-36304 [yeast_orfs2]
  • Chr I from 35156-36304 [yeastorf3.fasta]
  • (P39714) (R,R)-butanediol dehydrogenase (EC 1.1.1.4) [4932.FASTACCERV.txt]
  • BDH1 SGDID:S0000056, Chr I from 35156-36304, Verified ORF [yeastflysequest.fasta]
  • Bdh1p [Saccharomyces cerevisiae]gi|731293|sp|P39714|BDH1_YEAST (R,R)-butanediol dehydrogenasegi|595526|gb|AAC04974.1| Yal060wp [Saccharomyces cerevisiae]gi|1077489|pir||S51962 FUN49 protein - yeast (Saccharomyces cerevisiae) [nrdb_11152004_Chlamydomonas]
  • BDH1 SGDID:S000000056, Chr I from 35156-36304, Verified ORF, "NAD-dependent (2R,3R)-2,3-butanediol dehydrogenase, a zinc-containing medium-chain alcohol dehydrogenase, produces 2,3-butanediol from acetoin during fermentation and allows using 2,3-butanedio [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • BDH1 SGDID:S000000056, Chr I from 35156-36304, Verified ORF, "NAD-dependent (R,R)-butanediol dehydrogenase, catalyzes oxidation of (R,R)-2,3-butanediol to (3R)-acetoin, oxidation of meso-butanediol to (3S)-acetoin, and reduction of acetoin; enhances use o [SGD_S-cerevisiae_na_08-19-2008_con_reversed.fasta]
  • Yal060wp [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • NAD-dependent (2R,3R)-2,3-butanediol dehydrogenase, a zinc-containing medium-chain alcohol dehydrogenase, produces 2,3-butanediol from acetoin during fermentation and allows using 2,3-butanediol as a carbon source during aerobic growth; Bdh1p [Saccharomyc [nr-271106-contam.fasta]
  • (R,R)-butanediol dehydrogenase [nr-271106-contam.fasta]
  • BDH1 SGDID:S000000056, Chr I from 35156-36304, Verified ORF, "NAD-dependent (R,R)-butanediol dehydrogenase, catalyzes oxidation of (R,R)-2,3-butanediol to (3R)-acetoin, oxidation of meso-butanediol to (3S)-acetoin, and reduction of acetoin; enhances use of 2,3-butanediol as an aerobic carbon source" [yeast-bovrabprots.fasta]
  • BDH1 SGDID:S000000056, Chr I from 35156-36304, Verified ORF, "NAD-dependent (2R,3R)-2,3-butanediol dehydrogenase, a zinc-containing medium-chain alcohol dehydrogenase, produces 2,3-butanediol from acetoin during fermentation and allows using 2,3-butanediol as a carbon source during aerobic growth" [yeast-contam_custom.fasta]
  • [chemostatdb.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 382 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed articleLink to PubMed article]
    Biological Process: glucose catabolic process to butanediol [IDALink to PubMed article]
    Molecular Function: (R,R)-butanediol dehydrogenase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRALAYFKKG DIHFTNDIPR PEIQTDDEVI IDVSWCGICG SDLHEYLDGP IFMPKDGECH  60
   61 KLSNAALPLA MGHEMSGIVS KVGPKVTKVK VGDHVVVDAA SSCADLHCWP HSKFYNSKPC 120
  121 DACQRGSENL CTHAGFVGLG VISGGFAEQV VVSQHHIIPV PKEIPLDVAA LVEPLSVTWH 180
  181 AVKISGFKKG SSALVLGAGP IGLCTILVLK GMGASKIVVS EIAERRIEMA KKLGVEVFNP 240
  241 SKHGHKSIEI LRGLTKSHDG FDYSYDCSGI QVTFETSLKA LTFKGTATNI AVWGPKPVPF 300
  301 QPMDVTLQEK VMTGSIGYVV EAFEEVVRAI HNGDIAMEDC KQLITGKQRI EDGWEKGFQE 360
  361 LMDHKESNVK ILLTPNNHGE MK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) BDH1 BDH2
    View Details Krogan NJ, et al. (2006) BDH1 BDH2

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MIA40 No Comments Hazbun TR, et al. (2003)
    View Run MLP2 #31 Asynchronous Prep (Protease cleavage) Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data BDH1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..173]
    [343..382]    		 PSI-BLAST 388.154902 Ketose reductase (sorbitol dehydrogenase)
    2 View Details [174..342] PSI-BLAST 388.154902 Ketose reductase (sorbitol dehydrogenase)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • ethanol binding
    		•  3.52197234018599 bayes_pls_golite062009
  • NAD or NADH binding
    		•  3.39892156245282 bayes_pls_golite062009
  • retinol dehydrogenase activity
    		•  3.36841077419754 bayes_pls_golite062009
  • L-iditol 2-dehydrogenase activity
    		•  3.00103406168296 bayes_pls_golite062009
  • alcohol dehydrogenase (NAD) activity
    		•  2.94416173750168 bayes_pls_golite062009
  • retinol binding
    		•  2.90377414635828 bayes_pls_golite062009
  • chaperone binding
    		•  2.79912653573494 bayes_pls_golite062009
  • alcohol dehydrogenase activity, zinc-dependent
    		•  2.26153457113968 bayes_pls_golite062009
  • NADPH:quinone reductase activity
    		•  2.16668841986245 bayes_pls_golite062009
  • alcohol binding
    		•  2.01620480773869 bayes_pls_golite062009
  • all-trans retinal binding
    		•  1.96535395605564 bayes_pls_golite062009
  • benzaldehyde dehydrogenase activity
    		•  1.81250968237368 bayes_pls_golite062009
  • catalytic activity
    		•  1.79741889688267 bayes_pls_golite062009
  • oxidoreductase activity
    		•  0.9367410227151 bayes_pls_golite062009
  • S-(hydroxymethyl)glutathione dehydrogenase activity
    		•  0.779874038752102 bayes_pls_golite062009
  • oxidoreductase activity, acting on CH-OH group of donors
    		•  0.418775403210681 bayes_pls_golite062009
  • L-arabinitol 2-dehydrogenase activity
    		•  0.382131941157781 bayes_pls_golite062009
  • 3-hydroxyacyl-CoA dehydrogenase activity
    		•  0.36426941921419 bayes_pls_golite062009
  • glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) activity
    		•  0.361275519814065 bayes_pls_golite062009
  • coenzyme binding
    		•  0.35922330382799 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
    		•  0.32207755075663 bayes_pls_golite062009
  • binding
    		•  0.311888962066118 bayes_pls_golite062009
  • glyceraldehyde-3-phosphate dehydrogenase activity
    		•  0.298691872199351 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.179327587154303 bayes_pls_golite062009
  • DNA binding
    		•  0.0742540086107448 bayes_pls_golite062009
  • retinal binding
    		•  0.00342169427806049 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.56

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle