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Protein Overview: CNE1

General Information:
Name(s) found: CNE1 / YAL058W [SGD]
Description(s) found:
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  • gi|6319260|ref|NP_009343.1| Calnexin; integral membrane ER chaperone involved in folding and quality control of glycoproteins; chaperone activity is inhibited by Mpd1p, with which Cne1p interacts; 24% identical to mammalian calnexin; Ca+ binding not yet s [NCBI NR]
  • gi|595528|gb|AAC04976.1| Cne1p: calnexin homolog [Saccharomyces cerevisiae] [NCBI NR]
  • gi|5511|emb|CAA47100.1| calnexin homologue [Saccharomyces cerevisiae] [NCBI NR]
  • gi|51013291|gb|AAT92939.1| YAL058W [Saccharomyces cerevisiae] [NCBI NR]
  • pir||S29347 calnexin homolog YAL058w - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|171153|gb|AAA65967.1| calnexin [Saccharomyces cerevisiae] [NCBI NR]
  • gi|115549|sp|P27825.1|CALX_YEAST RecName: Full=Calnexin homolog; Flags: Precursor [NCBI NR]
  • Calnexin homolog OS=Saccharomyces cerevisiae GN=CNE1 PE=1 SV=1 [Swiss-Prot]
  • CNE1 Calnexin, involved in regulation of secretion [mips]
  • Calnexin; integral membrane ER chaperone involved in folding and quality control of glycoproteins; chaperone activity is inhibited by Mpd1p, with which Cne1p interacts; 24% identical to mammalian calnexin; Ca+ binding not yet shown in yeast [SGD]
  • CNE1, Chr I from 37465-38973 [yeast_orfs2]
  • Chr I from 37465-38973 [yeastorf3.fasta]
  • (P27825) Calnexin homolog precursor [4932.FASTACCERV.txt]
  • CNE1 SGDID:S0000054, Chr I from 37465-38973, Verified ORF [yeastflysequest.fasta]
  • Cne1p [Saccharomyces cerevisiae]gi|51013291|gb|AAT92939.1| YAL058W [Saccharomyces cerevisiae]gi|5511|emb|CAA47100.1| calnexin homologue [Saccharomyces cerevisiae]gi|115549|sp|P27825|CALX_YEAST Calnexin homolog precursorgi|320646|pir||S29347 calnexin h [nrdb_11152004_Chlamydomonas]
  • CNE1 SGDID:S000000054, Chr I from 37465-38973, Verified ORF, "Calnexin; integral membrane ER chaperone involved in the folding and quality control of glycoproteins, 24% identical and 31% similar to mammalian calnexin but the Ca+ binding typical of calnexi [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • CNE1 SGDID:S000000054, Chr I from 37465-38973, Verified ORF, "Calnexin; integral membrane ER chaperone involved in folding and quality control of glycoproteins; chaperone activity is inhibited by Mpd1p, with which Cne1p interacts; 24% identical to mammali [yeast-contam.fasta]
  • Calnexin homolog precursor [nr-271106-contam.fasta]
  • calnexin [nr-271106-contam.fasta]
  • calnexin homologue [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Calnexin; integral membrane ER chaperone involved in folding and quality control of glycoproteins; chaperone activity is inhibited by Mpd1p, with which Cne1p interacts; 24% identical to mammalian calnexin; Ca+ binding not yet shown in yeast; Cne1p [Saccha [nr-271106-contam.fasta]
  • Cne1p: calnexin homolog [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • YAL058W [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • CNE1 SGDID:S000000054, Chr I from 37465-38973, Verified ORF, "Calnexin; integral membrane ER chaperone involved in folding and quality control of glycoproteins; chaperone activity is inhibited by Mpd1p, with which Cne1p interacts; 24% identical to mammalian calnexin; Ca+ binding not yet shown in yeast" [yeast-bovrabprots.fasta]
  • [chemostatdb.fasta]
  • Calnexin homolog OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=CNE1 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • CNE1 SGDID:S000000054, Chr I from 37464-38972, Genome Release 64-1-1, Verified ORF, "Calnexin; integral membrane ER chaperone involved in folding and quality control of glycoproteins; chaperone activity is inhibited by Mpd1p, with which Cne1p interacts; 24% identical to mammalian calnexin; Ca+ binding not yet shown in yeast" [yeast-030211-contam.fasta]
  • CNE1 SGDID:S000000054, Chr I from 37464-38972, Genome Release 64-2-1, Verified ORF, "Calnexin; integral membrane ER chaperone involved in folding and quality control of glycoproteins; chaperone activity is inhibited by Mpd1p, with which Cne1p interacts; 24% identical to mammalian calnexin; Ca+ binding not yet shown in yeast" [20141208_orf_trans.fasta]
  • YAL058W SGDID:S000000054, Chr I from 37464-38972, Genome Release 64-1-1, Verified ORF, "Calnexin; integral membrane ER chaperone involved in folding and quality control of glycoproteins; chaperone activity is inhibited by Mpd1p, with which Cne1p interacts; 24% identical to mammalian calnexin; Ca+ binding not yet shown in yeast" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 502 amino acids

    Gene Ontology:
    Cellular Component: integral to endoplasmic reticulum membrane [IDALink to PubMed article]
    Biological Process: protein folding [IMPLink to PubMed article]
    ER-associated protein catabolic process [IMPLink to PubMed article]
    Molecular Function: unfolded protein binding [IMPLink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKFSAYLWWL FLNLALVKGT SLLSNVTLAE DSFWEHFQAY TNTKHLNQEW ITSEAVNNEG  60
   61 SKIYGAQWRL SQGRLQGSAW DKGIAVRTGN AAAMIGHLLE TPINVSETDT LVVQYEIKLD 120
  121 NSLTCGGAFI KLMSGFMNVE ALKHYAPDTE GVELVFGPDY CAPEINGVQF AINKVDKITH 180
  181 ESKLRYLQEM PLSKLTDTSQ SHLYTLIIDE SAQSFQILID GKTVMVREHI EDKKKVNFEP 240
  241 PITPPLMIPD VSVAKPHDWD DRIRIPDPEA VKLSDRDERD PLMIPHPDGT EPPEWNSSIP 300
  301 EYILDPNAQK PSWWKELEHG EWIPPMIKNP LCTAERGCGQ QIPGLINNAK YKGPGELNEI 360
  361 INPNYMGEWH PPEIENPLYY EEQHPLRIEN VISGVILEFW SGSPNMLISN IYVGKNVTEA 420
  421 QIIGNKTWLM RDRAFRGSDG PTERKFMNSR LGNLQTTFHN ERESPNPFDR IIDRILEQPL 480
  481 KFVLTAAVVL LTTSVLCCVV FT

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data CNE1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..247]
    [376..502]    		 PSI-BLAST 624.54902 Calnexin
    2 View Details [248..375] PSI-BLAST 624.54902 Calnexin

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • complement component C1q binding
    		•  4.81971897425786 bayes_pls_golite062009
  • steroid hormone receptor binding
    		•  4.11346029337178 bayes_pls_golite062009
  • androgen receptor binding
    		•  3.88449123711676 bayes_pls_golite062009
  • zymosan binding
    		•  3.41405218556083 bayes_pls_golite062009
  • nuclear hormone receptor binding
    		•  3.3517714661273 bayes_pls_golite062009
  • binding
    		•  3.24845777545007 bayes_pls_golite062009
  • hormone receptor binding
    		•  3.2405597896178 bayes_pls_golite062009
  • structural molecule activity
    		•  3.0286932947016 bayes_pls_golite062009
  • unfolded protein binding
    		•  2.94586353433162 bayes_pls_golite062009
  • protein binding
    		•  2.62442480878692 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.5786381493734 bayes_pls_golite062009
  • transcription repressor activity
    		•  2.42862869142896 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.33705817770533 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  2.16616430987996 bayes_pls_golite062009
  • actin binding
    		•  2.0669297251683 bayes_pls_golite062009
  • DNA binding
    		•  2.05388036301171 bayes_pls_golite062009
  • carbohydrate binding
    		•  1.90829797790335 bayes_pls_golite062009
  • sugar binding
    		•  1.89824804892868 bayes_pls_golite062009
  • receptor binding
    		•  1.70102429470678 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.69567186252006 bayes_pls_golite062009
  • signal transducer activity
    		•  1.69567186252006 bayes_pls_golite062009
  • cation binding
    		•  1.67588357161378 bayes_pls_golite062009
  • metal ion binding
    		•  1.67588357161378 bayes_pls_golite062009
  • ion binding
    		•  1.66900324045723 bayes_pls_golite062009
  • NACHT domain binding
    		•  1.53382521801494 bayes_pls_golite062009
  • integrin binding
    		•  1.36513827550387 bayes_pls_golite062009
  • transporter activity
    		•  1.29150662073327 bayes_pls_golite062009
  • chaperone binding
    		•  1.28860282614448 bayes_pls_golite062009
  • glycosaminoglycan binding
    		•  1.25720635817943 bayes_pls_golite062009
  • protein complex binding
    		•  1.23240411516711 bayes_pls_golite062009
  • RNA binding
    		•  1.22339134958708 bayes_pls_golite062009
  • heparin binding
    		•  1.15897181987617 bayes_pls_golite062009
  • transcription factor activity
    		•  1.15427978494805 bayes_pls_golite062009
  • transcription activator activity
    		•  1.11465354227601 bayes_pls_golite062009
  • polysaccharide binding
    		•  1.09475063562581 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.07075219961504 bayes_pls_golite062009
  • receptor activity
    		•  0.946182305131481 bayes_pls_golite062009
  • growth factor activity
    		•  0.850395354506359 bayes_pls_golite062009
  • pattern binding
    		•  0.83687933614214 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  0.814690646803591 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.801327928563072 bayes_pls_golite062009
  • mRNA binding
    		•  0.67699218614597 bayes_pls_golite062009
  • monosaccharide binding
    		•  0.5678336426881 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.546870122670733 bayes_pls_golite062009
  • extracellular matrix structural constituent
    		•  0.52360080681204 bayes_pls_golite062009
  • calcium ion binding
    		•  0.416416901481401 bayes_pls_golite062009
  • hydrolase activity
    		•  0.374282208763552 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  0.160855218996334 bayes_pls_golite062009
  • growth factor binding
    		•  0.0922754536898114 bayes_pls_golite062009
  • cytokine binding
    		•  0.0273545648165503 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle