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Protein Overview: Pkcdelta-PC, Pkc...

General Information:
Name(s) found: Pkcdelta-PD / FBpp0289214 [FlyBase]
Pkcdelta-PC / FBpp0289213 [FlyBase]
Description(s) found:
Found 31 descriptions.
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  • The gene Protein kinase C Ã?&#142;Ã?´ is referred to in FlyBase by the symbol Dmel\PkcÃ?&#142;Ã?´ (CG42349, FBgn0259680). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:12326259..12347683. It has the cytological map location 11A10-11A11. Based on sequence similarity, it is predicted to have molecular function</span>: protein kinase C activity; diacylglycerol binding. It is reported to be involved in the biological process</span>: protein amino acid phosphorylation. 8 alleles are reported. No phenotypic data is available. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
  • The gene Protein kinase C Ã?&#142;Ã?´ is referred to in FlyBase by the symbol Dmel\PkcÃ?&#142;Ã?´ (CG42349, FBgn0259680). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:12326259..12347683. It has the cytological map location 11A10-11A11. Based on sequence similarity, it is predicted to have molecular function</span>: protein kinase C activity; diacylglycerol binding. It is reported to be involved in the biological process</span>: protein amino acid phosphorylation. 8 alleles are reported. No phenotypic data is available. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 671 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: intracellular signaling pathway [IEA]
    protein amino acid phosphorylation [IEA][NAS]
    Molecular Function: ATP binding [IEA]
    diacylglycerol binding [ISS]
    protein serine/threonine kinase activity [NAS]
    protein kinase C activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MMFTRAQVRK QKTSNSSSQR PRSSGGSTRH ETRYKQSSTS SSGAGSGLSG ASGASGARRD  60
   61 QYRDRDHYGK HSFELPRQHS KEEAYHRDRE SSAGGVDRGE RSGIGGNGGG VTGGGVYVDR 120
  121 RTRPRSITNR RGAIKHQKTH DINGHRFVAK FFRQPTFCAF CNLFLWGFGK QGYQCIICQT 180
  181 VVHKKCHDKL LGKCSGSVFT SASTILLRER FKIDMPHRFK PHTFMSPTFC DHCGSLMGGF 240
  241 FIQGLKCEEC DVNCHKKCER LTANLCGVNQ KLIVEALNHV KRGAREARDS PSTPPSLNPA 300
  301 YKIEASEEHD ETSYTYSQFQ KSGRFTAPAT VIPRFKNYSV DDFHFLAVLG KGSFGKVLLA 360
  361 ELRDTTYYYA IKCLKKDVVL EDDDVDSTLI ERKVLALGTK HPYLCHLFCT FQTESHLFFV 420
  421 MEYLNGGDLM FHIQESGRFS EERARFYGAE IISGLKFLHK KGIIYRDLKL DNVLLDYEGH 480
  481 VRIADFGMCK LQIYLDKTAD SFCGTPDYMA PEIIKGEKYN QNVDWWSFGV LLYEMLIGQS 540
  541 PFSGCDEDEL FWSICNEIPW FPVYISAEAT GILKGLLEKD YTKRIGSQYS PAGDIADHIF 600
  601 FRPIDWGLLE KRQIEPPFKP QVKHPLDTQY FDRVFTRERV RLTPIDKEIL ASMDQKQFHG 660
  661 FTYTNPHITL D

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..76] deduced N/A No confident structure predictions are available.
    2 View Details [77..195] PSI-BLAST 14.045757 Crystal Structure of the Human Beta2-Chimaerin
    3 View Details [196..273] FFAS03 2.91 No description for 2db6A was found.
    4 View Details [274..338] PSI-BLAST 49.522879 CRYSTAL STRUCTURE OF HUMAN TYROSINE-PROTEIN KINASE C-SRC
    5 View Details [339..671] PSI-BLAST 97.221849 No description for 2i0eA was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • general RNA polymerase II transcription factor activity
    		•  3.71782887289779 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.86705824967236 bayes_pls_golite062009
  • binding
    		•  2.79128751898373 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  2.10625597744594 bayes_pls_golite062009
  • DNA binding
    		•  2.06132216820898 bayes_pls_golite062009
  • kinase activity
    		•  2.03632850156074 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.91441035614579 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.8531437045627 bayes_pls_golite062009
  • protein kinase activity
    		•  1.62921423829738 bayes_pls_golite062009
  • transferase activity
    		•  1.4550521488922 bayes_pls_golite062009
  • transcription factor activity
    		•  1.39657429296564 bayes_pls_golite062009
  • GTPase regulator activity
    		•  1.39167263636091 bayes_pls_golite062009
  • nucleoside-triphosphatase regulator activity
    		•  1.37139209958305 bayes_pls_golite062009
  • protein binding
    		•  1.29100556128076 bayes_pls_golite062009
  • signal transducer activity
    		•  1.25507073225414 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.25507073225414 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  1.10685156896266 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.956859696337723 bayes_pls_golite062009
  • enzyme regulator activity
    		•  0.911061212692491 bayes_pls_golite062009
  • guanyl-nucleotide exchange factor activity
    		•  0.907368864863833 bayes_pls_golite062009
  • small GTPase regulator activity
    		•  0.661240850692236 bayes_pls_golite062009
  • kinase binding
    		•  0.494958567742569 bayes_pls_golite062009
  • catalytic activity
    		•  0.194464246602439 bayes_pls_golite062009
  • lipid binding
    		•  0.170968368793169 bayes_pls_golite062009
    3 No functions predicted.
    4
    Term Confidence Notes
  • cytoskeletal protein binding
    		•  4.41722924924158 bayes_pls_golite062009
  • actin binding
    		•  3.91045208670052 bayes_pls_golite062009
  • binding
    		•  3.06905798270146 bayes_pls_golite062009
  • actin filament binding
    		•  2.72908433443928 bayes_pls_golite062009
  • protein binding
    		•  2.08632303609243 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.34867629228264 bayes_pls_golite062009
  • signal transducer activity
    		•  1.34867629228264 bayes_pls_golite062009
  • transporter activity
    		•  1.30447542854757 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.08558010881058 bayes_pls_golite062009
  • insulin receptor binding
    		•  1.02499153496761 bayes_pls_golite062009
  • structural molecule activity
    		•  0.989403012920596 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.820987609295422 bayes_pls_golite062009
  • vinculin binding
    		•  0.666656406096231 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.570864043201529 bayes_pls_golite062009
  • structural constituent of muscle
    		•  0.52430033936893 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  0.371928447183203 bayes_pls_golite062009
  • receptor binding
    		•  0.351326788023913 bayes_pls_golite062009
  • insulin receptor substrate binding
    		•  0.30555304014394 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.277388904131159 bayes_pls_golite062009
    5 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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