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View Structure Prediction Details

Protein: Pkcdelta-PC, Pkc...
Organism: Drosophila melanogaster
Length: 671 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Pkcdelta-PC, Pkc....

Description E-value Query
Range
Subject
Range
gi|109039102 - gi|109039102|ref|XP_001083320.1| PREDICTED: similar to protein kinase C, delta [Macaca mulatta]
534.0 [0..52] [671..538]

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Predicted Domain #1
Region A:
Residues: [1-76]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MMFTRAQVRK QKTSNSSSQR PRSSGGSTRH ETRYKQSSTS SSGAGSGLSG ASGASGARRD  60
   61 QYRDRDHYGK HSFELP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [77-195]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RQHSKEEAYH RDRESSAGGV DRGERSGIGG NGGGVTGGGV YVDRRTRPRS ITNRRGAIKH  60
   61 QKTHDINGHR FVAKFFRQPT FCAFCNLFLW GFGKQGYQCI ICQTVVHKKC HDKLLGKCS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 14.045757
Match: 1xa6A
Description: Crystal Structure of the Human Beta2-Chimaerin
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
general RNA polymerase II transcription factor activity 3.71782887289779 bayes_pls_golite062009
transcription regulator activity 2.86705824967236 bayes_pls_golite062009
binding 2.79128751898373 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 2.10625597744594 bayes_pls_golite062009
DNA binding 2.06132216820898 bayes_pls_golite062009
kinase activity 2.03632850156074 bayes_pls_golite062009
nucleic acid binding 1.91441035614579 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 1.8531437045627 bayes_pls_golite062009
protein kinase activity 1.62921423829738 bayes_pls_golite062009
transferase activity 1.4550521488922 bayes_pls_golite062009
transcription factor activity 1.39657429296564 bayes_pls_golite062009
GTPase regulator activity 1.39167263636091 bayes_pls_golite062009
nucleoside-triphosphatase regulator activity 1.37139209958305 bayes_pls_golite062009
protein binding 1.29100556128076 bayes_pls_golite062009
signal transducer activity 1.25507073225414 bayes_pls_golite062009
molecular transducer activity 1.25507073225414 bayes_pls_golite062009
RNA polymerase II transcription factor activity 1.10685156896266 bayes_pls_golite062009
protein serine/threonine kinase activity 0.956859696337723 bayes_pls_golite062009
enzyme regulator activity 0.911061212692491 bayes_pls_golite062009
guanyl-nucleotide exchange factor activity 0.907368864863833 bayes_pls_golite062009
small GTPase regulator activity 0.661240850692236 bayes_pls_golite062009
kinase binding 0.494958567742569 bayes_pls_golite062009
catalytic activity 0.194464246602439 bayes_pls_golite062009
lipid binding 0.170968368793169 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [196-273]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GSVFTSASTI LLRERFKIDM PHRFKPHTFM SPTFCDHCGS LMGGFFIQGL KCEECDVNCH  60
   61 KKCERLTANL CGVNQKLI

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 2.91
Match: 2db6A
Description: No description for 2db6A was found.

Predicted Domain #4
Region A:
Residues: [274-338]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VEALNHVKRG AREARDSPST PPSLNPAYKI EASEEHDETS YTYSQFQKSG RFTAPATVIP  60
   61 RFKNY

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 49.522879
Match: 1fmkA
Description: CRYSTAL STRUCTURE OF HUMAN TYROSINE-PROTEIN KINASE C-SRC
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
cytoskeletal protein binding 4.41722924924158 bayes_pls_golite062009
actin binding 3.91045208670052 bayes_pls_golite062009
binding 3.06905798270146 bayes_pls_golite062009
actin filament binding 2.72908433443928 bayes_pls_golite062009
protein binding 2.08632303609243 bayes_pls_golite062009
molecular transducer activity 1.34867629228264 bayes_pls_golite062009
signal transducer activity 1.34867629228264 bayes_pls_golite062009
transporter activity 1.30447542854757 bayes_pls_golite062009
transmembrane transporter activity 1.08558010881058 bayes_pls_golite062009
insulin receptor binding 1.02499153496761 bayes_pls_golite062009
structural molecule activity 0.989403012920596 bayes_pls_golite062009
substrate-specific transporter activity 0.820987609295422 bayes_pls_golite062009
vinculin binding 0.666656406096231 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.570864043201529 bayes_pls_golite062009
structural constituent of muscle 0.52430033936893 bayes_pls_golite062009
structural constituent of cytoskeleton 0.371928447183203 bayes_pls_golite062009
receptor binding 0.351326788023913 bayes_pls_golite062009
insulin receptor substrate binding 0.30555304014394 bayes_pls_golite062009
ion transmembrane transporter activity 0.277388904131159 bayes_pls_golite062009

Predicted Domain #5
Region A:
Residues: [339-671]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SVDDFHFLAV LGKGSFGKVL LAELRDTTYY YAIKCLKKDV VLEDDDVDST LIERKVLALG  60
   61 TKHPYLCHLF CTFQTESHLF FVMEYLNGGD LMFHIQESGR FSEERARFYG AEIISGLKFL 120
  121 HKKGIIYRDL KLDNVLLDYE GHVRIADFGM CKLQIYLDKT ADSFCGTPDY MAPEIIKGEK 180
  181 YNQNVDWWSF GVLLYEMLIG QSPFSGCDED ELFWSICNEI PWFPVYISAE ATGILKGLLE 240
  241 KDYTKRIGSQ YSPAGDIADH IFFRPIDWGL LEKRQIEPPF KPQVKHPLDT QYFDRVFTRE 300
  301 RVRLTPIDKE ILASMDQKQF HGFTYTNPHI TLD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 97.221849
Match: 2i0eA
Description: No description for 2i0eA was found.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle