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Protein Overview: pqe-1

General Information:
Name(s) found: pqe-1 / CE39256 [WormBase]
Description(s) found:
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  • WBGene00004095 locus:pqe-1 status:Confirmed UniProt:G8JYC4 protein_id:CCD71616.1 [WormBase]
  • gi|78771786|gb|ABB51184.1| Polyq (poly glutamine tract) toxicity enhancer protein 1, isoform g [Caenorhabditis elegans] [NCBI NR]
  • gi|115532678|ref|NP_001040854.1| PolyQ (poly glutamine tract) toxicity Enhancer family member (pqe-1) [Caenorhabditis elegans] [NCBI NR]
  • CE39256 WBGene00004095 locus:pqe-1 status:Confirmed UniProt:Q304E8_CAEEL protein_id:ABB51184.1 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta]
  • CE39256 WBGene00004095 locus:pqe-1 status:Confirmed UniProt:Q304E8_CAEEL protein_id:ABB51184.1| [wormORF-contam.fasta]
  • CE39256 WBGene00004095 locus:pqe-1 status:Confirmed TR:Q304E8 protein_id:ABB51184.1 [wormpep160-contam.fasta]
  • Polyq (poly glutamine tract) toxicity enhancer protein 1, isoform g [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • PolyQ (poly glutamine tract) toxicity Enhancer family member (pqe-1) [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • CE39256 WBGene00004095 locus:pqe-1 status:Confirmed UniProt:Q304E8 protein_id:ABB51184.1 [wormbase_c-elegans_2.11_01-10-2010_reversed.fasta]
  • [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr]
  • CE39256 WBGene00004095 locus:pqe-1 status:Confirmed UniProt:G8JYC4 protein_id:CCD71616.1 [wormbase_c_elegans_ws231_03-13-2012_reversed.fasta]
  • Isoform of Q10124, PolyQ (Poly glutamine tract) toxicity Enhancer OS=Caenorhabditis elegans GN=pqe-1 PE=1 SV=1 [CAEEL.fasta.20160308]
    • Organism: Caenorhabditis elegans
    Length: 672 amino acids

    Gene Ontology:
    Cellular Component: intracellular [IEALink to PubMed article]
    Biological Process: NONE FOUND
    Molecular Function: exonuclease activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFNGGYGSGN SFNLQNYAPI DPMTGIPGFG PSQNAQQQQQ QASAPGTSSG GPSQAVSGAS  60
   61 SGASMKTEPV ARQVSTAQMK RDLEQAAVYV PTPIPKKDAK SSENRAKEKQ KPMNFQKRPT 120
  121 SSASVDSNDD GVHIPAKRMA HASSVPGPSR SKPPMIGAVK NRPNHTEMLD KRNKESEEKR 180
  181 RKDRDELERL RNKKHTTEEE KIKMARLQNA LKVVGKAAGL KATVKKELTG SPAKKQKPAP 240
  241 AVPKILDFSV GRTFTAIRQT AIKLVFDTFL ERDSPNAARE AQEFELSIAK QYTDGQKYRI 300
  301 NIGHKVAALR KENTSGILEV NKNAVSHDKI LAGGPKDNCT VARGRKTHVD HRQLSIEKLH 360
  361 PLLLQFKLTT SELETNAYPM RRDGSTKAVS IADTVYTQNK KMFLDDYDMS RNCSRCNKEF 420
  421 KLSPNGTMIR STGICRYHNR GVAINGKRDT FRKRYSCCNE EFNVALGCKF SDVHVTDQLF 480
  481 KKELSTFVST PVPVPNDQRS TRVYALDCEM VYTIAGPALA RLTMVDMQRN RVLDVFVKPP 540
  541 TDVLDPNTEF SGLTMEQINS APDTLKTCHQ KLFKYVNADT ILIGHSLESD LKAMRVVHKN 600
  601 VIDTAILFRS TRDTKVALKV LSAKLLHKNI QGDNEDAIGH DSMEDALTCV DLIFYGLRNP 660
  661 ESIAIREANT NC

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..250] FFAS03 1.17 THE BLUETONGUE VIRUS (BTV) CORE BINDS DSRNA
    2 View Details [251..399] deduced N/A No confident structure predictions are available.
    3 View Details [400..501] FFAS03 1.0 Solution Structure of the N-terminal Zinc Fingers of the Xenopus laevis double stranded RNA binding protein ZFa
    4 View Details [502..672] PSI-BLAST 43.09691 human ISG20

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • transcription regulator activity
    		•  3.37529385176635 bayes_pls_golite062009
  • DNA binding
    		•  3.3049326844117 bayes_pls_golite062009
  • nucleic acid binding
    		•  3.24981360535232 bayes_pls_golite062009
  • transcription factor activity
    		•  2.44389510173662 bayes_pls_golite062009
  • binding
    		•  2.40458515823407 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  1.57041104288348 bayes_pls_golite062009
  • transcription activator activity
    		•  1.20323819132961 bayes_pls_golite062009
  • RNA binding
    		•  0.84315767580466 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.732558534458316 bayes_pls_golite062009
  • protein binding
    		•  0.721263040163177 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.686318575498149 bayes_pls_golite062009
  • chromatin binding
    		•  0.626365497850853 bayes_pls_golite062009
  • transcription factor binding
    		•  0.515821187939278 bayes_pls_golite062009
  • catalytic activity
    		•  0.263007611601737 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  0.200483461579207 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.113925660147477 bayes_pls_golite062009
    4
    Term Confidence Notes
  • nuclease activity
    		•  2.65398446409354 bayes_pls_golite062009
  • ribonuclease activity
    		•  2.17677493546761 bayes_pls_golite062009
  • endoribonuclease activity, producing 5'-phosphomonoesters
    		•  1.74431545836806 bayes_pls_golite062009
  • exoribonuclease activity
    		•  1.70600098208524 bayes_pls_golite062009
  • exoribonuclease activity, producing 5'-phosphomonoesters
    		•  1.65911933935463 bayes_pls_golite062009
  • endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters
    		•  1.59628511603826 bayes_pls_golite062009
  • hydrolase activity
    		•  1.52504970608306 bayes_pls_golite062009
  • exonuclease activity
    		•  1.4327316829508 bayes_pls_golite062009
  • 3'-5'-exoribonuclease activity
    		•  1.42069917818896 bayes_pls_golite062009
  • catalytic activity
    		•  1.25233849524628 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  1.19753926150484 bayes_pls_golite062009
    		• 1.18236432793831 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.10433412699603 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.04079362397031 bayes_pls_golite062009
  • endonuclease activity
    		•  0.991569665925888 bayes_pls_golite062009
  • 3'-5' exonuclease activity
    		•  0.86862629020506 bayes_pls_golite062009
  • DNA binding
    		•  0.860359347662869 bayes_pls_golite062009
  • binding
    		•  0.762139256580538 bayes_pls_golite062009
  • RNA binding
    		•  0.750194803368593 bayes_pls_golite062009
  • exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters
    		•  0.389326716045122 bayes_pls_golite062009
  • transcription factor activity
    		•  0.332903382446869 bayes_pls_golite062009
  • ribonuclease H activity
    		•  0.244270343650265 bayes_pls_golite062009
  • endoribonuclease activity
    		•  0.016619833072142 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle