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View Structure Prediction Details

Protein: pqe-1
Organism: Caenorhabditis elegans
Length: 672 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for pqe-1.

Description E-value Query
Range		 Subject
Range
pqe-1 - status:Confirmed UniProt:Q10124 protein_id:AAM45368.1
 423.0 [0..1] [672..1]

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Predicted Domain #1
Region A:
Residues: [1-250] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFNGGYGSGN SFNLQNYAPI DPMTGIPGFG PSQNAQQQQQ QASAPGTSSG GPSQAVSGAS  60
   61 SGASMKTEPV ARQVSTAQMK RDLEQAAVYV PTPIPKKDAK SSENRAKEKQ KPMNFQKRPT 120
  121 SSASVDSNDD GVHIPAKRMA HASSVPGPSR SKPPMIGAVK NRPNHTEMLD KRNKESEEKR 180
  181 RKDRDELERL RNKKHTTEEE KIKMARLQNA LKVVGKAAGL KATVKKELTG SPAKKQKPAP 240
  241 AVPKILDFSV

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.17
Match: 1h1kI
Description: THE BLUETONGUE VIRUS (BTV) CORE BINDS DSRNA
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [251-399] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GRTFTAIRQT AIKLVFDTFL ERDSPNAARE AQEFELSIAK QYTDGQKYRI NIGHKVAALR  60
   61 KENTSGILEV NKNAVSHDKI LAGGPKDNCT VARGRKTHVD HRQLSIEKLH PLLLQFKLTT 120
  121 SELETNAYPM RRDGSTKAVS IADTVYTQN

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [400-501] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KKMFLDDYDM SRNCSRCNKE FKLSPNGTMI RSTGICRYHN RGVAINGKRD TFRKRYSCCN  60
   61 EEFNVALGCK FSDVHVTDQL FKKELSTFVS TPVPVPNDQR ST

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.0
Match: 1zu1A
Description: Solution Structure of the N-terminal Zinc Fingers of the Xenopus laevis double stranded RNA binding protein ZFa
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 3.37529385176635 bayes_pls_golite062009
DNA binding 3.3049326844117 bayes_pls_golite062009
nucleic acid binding 3.24981360535232 bayes_pls_golite062009
transcription factor activity 2.44389510173662 bayes_pls_golite062009
binding 2.40458515823407 bayes_pls_golite062009
RNA polymerase II transcription factor activity 1.57041104288348 bayes_pls_golite062009
transcription activator activity 1.20323819132961 bayes_pls_golite062009
RNA binding 0.84315767580466 bayes_pls_golite062009
sequence-specific DNA binding 0.732558534458316 bayes_pls_golite062009
protein binding 0.721263040163177 bayes_pls_golite062009
transcription repressor activity 0.686318575498149 bayes_pls_golite062009
chromatin binding 0.626365497850853 bayes_pls_golite062009
transcription factor binding 0.515821187939278 bayes_pls_golite062009
catalytic activity 0.263007611601737 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 0.200483461579207 bayes_pls_golite062009
transcription cofactor activity 0.113925660147477 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [502-672] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RVYALDCEMV YTIAGPALAR LTMVDMQRNR VLDVFVKPPT DVLDPNTEFS GLTMEQINSA  60
   61 PDTLKTCHQK LFKYVNADTI LIGHSLESDL KAMRVVHKNV IDTAILFRST RDTKVALKVL 120
  121 SAKLLHKNIQ GDNEDAIGHD SMEDALTCVD LIFYGLRNPE SIAIREANTN C

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 43.09691
Match: 1wljA
Description: human ISG20
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
nuclease activity 2.65398446409354 bayes_pls_golite062009
ribonuclease activity 2.17677493546761 bayes_pls_golite062009
endoribonuclease activity, producing 5'-phosphomonoesters 1.74431545836806 bayes_pls_golite062009
exoribonuclease activity 1.70600098208524 bayes_pls_golite062009
exoribonuclease activity, producing 5'-phosphomonoesters 1.65911933935463 bayes_pls_golite062009
endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 1.59628511603826 bayes_pls_golite062009
hydrolase activity 1.52504970608306 bayes_pls_golite062009
exonuclease activity 1.4327316829508 bayes_pls_golite062009
3'-5'-exoribonuclease activity 1.42069917818896 bayes_pls_golite062009
catalytic activity 1.25233849524628 bayes_pls_golite062009
hydrolase activity, acting on ester bonds 1.19753926150484 bayes_pls_golite062009
1.18236432793831 bayes_pls_golite062009
transcription regulator activity 1.10433412699603 bayes_pls_golite062009
nucleic acid binding 1.04079362397031 bayes_pls_golite062009
endonuclease activity 0.991569665925888 bayes_pls_golite062009
3'-5' exonuclease activity 0.86862629020506 bayes_pls_golite062009
DNA binding 0.860359347662869 bayes_pls_golite062009
binding 0.762139256580538 bayes_pls_golite062009
RNA binding 0.750194803368593 bayes_pls_golite062009
exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 0.389326716045122 bayes_pls_golite062009
transcription factor activity 0.332903382446869 bayes_pls_golite062009
ribonuclease H activity 0.244270343650265 bayes_pls_golite062009
endoribonuclease activity 0.016619833072142 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle