Protein Overview: SRBP2_RAT

General Information:
Name(s) found:	SRBP2_RAT [Swiss-Prot]
Description(s) found: SHOW ONLY BEST	gi\|76096332\|ref\|NP_001028866.1\| sterol regulatory element binding transcription factor 2 [Rattus norvegicus] [NCBI NR] gi\|74353805\|gb\|AAI01903.1\| Sterol regulatory element binding transcription factor 2 [Rattus norvegicus] [NCBI NR] gi\|123792976\|sp\|Q3T1I5.1\|SRBP2_RAT RecName: Full=Sterol regulatory element-binding protein 2; Short=SREBP-2; AltName: Full=Sterol regulatory element-binding transcription factor 2; Contains: RecName: Full=Processed sterol regulatory element-binding protei [NCBI NR] Sterol regulatory element-binding protein 2 OS=Rattus norvegicus GN=Srebf2 PE=2 SV=1 [Swiss-Prot] Tax_Id=10116 Sterol regulatory element binding factor 2 [EBI-IPI_rat_3.17_05-10-2006_con_reversed.fasta] Sterol regulatory element binding factor 2 [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] sterol regulatory element binding factor 2 [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Sterol regulatory element-binding protein 2 (SREBP-2) (Sterol regulatory element-binding transcription factor 2) [Contains: Processed sterol regulatory element-binding protein 2] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] sterol regulatory element binding transcription factor 2 [Rattus norvegicus] [NCBI-RefSeq_human-rat_na_04-07-2009_con_reversed.fasta] Sterol regulatory element binding factor 2 (predicted) [Rattus norvegicus] [nr-271106-contam.fasta] Tax_Id=10116 Gene_Symbol=Srebf2 Sterol regulatory element-binding protein 2 [rat-ipi-250309-contam.fasta] Sterol regulatory element-binding protein 2 OS=Rattus norvegicus GN=Srebf2 [011711_HMR.fasta]
Organism:	Rattus norvegicus
Length:	1133 amino acids
Gene Ontology:
Cellular Component:	microsome [IDA] Golgi membrane [IEA] endoplasmic reticulum [UNKNOWN][IEA] Golgi apparatus [IEA] endoplasmic reticulum membrane [IEA] nucleus [UNKNOWN][IDA][IEA] dendrite [IDA] cytoplasm [UNKNOWN][IDA] SREBP-SCAP-Insig complex [UNKNOWN][IEA] ER to Golgi transport vesicle membrane [IEA] membrane [IEA] integral to membrane [IEA] cytoplasmic vesicle [IEA]
Biological Process:	spermatogenesis [IEP] cholesterol metabolic process [IEA] lipid biosynthetic process [TAS] steroid metabolic process [IEA] positive regulation of transcription [IMP] aging [IEP] response to hormone stimulus [IMP] regulation of transcription [UNKNOWN][IEA] positive regulation of transcription from RNA polymerase II promoter [UNKNOWN][IDA] response to drug [IEP] response to lipid [IEP] response to lead ion [IEP] positive regulation of transcription via sterol regulatory element binding [UNKNOWN][IEA]
Molecular Function:	DNA binding [UNKNOWN] transcription factor activity [UNKNOWN][IEA] protein binding [UNKNOWN] protein C-terminus binding [UNKNOWN][IEA] transcription regulator activity [IEA] specific RNA polymerase II transcription factor activity [IDA] sequence-specific DNA binding [IDA] chromatin binding [IDA] [NOT]C-8 sterol isomerase activity [UNKNOWN]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDENSELGGL ETMETLTELG DELTLGDIDE MLQFVSNQVG EFSDLFSEQL CSSFPGGGGG  60
   61 SGSGGTSNNS SGRGTSGGAA DPAVQRSFSQ VPLSTFSPSS TSPQAPALQV KVSPTPPRAT 120
  121 PVLQPRPQPQ PQPPAQLQQQ TVMITPTFST APQTRIIQQP LIYQNAATSF QVLQPQVQSL 180
  181 VTSSQVQPVT IQQQVQTVQA QRVLTQTANG TLQTLAPATV QTVATPQVQQ VPVLVQPQII 240
  241 KTDSLVLTTL KTDGSPVMAA VQNPALTALT APIQTAALQV PTLVGSNGAI LTTMPVMMGQ 300
  301 EKVPIKQVPG GVKQLEPPKE GERRTTHNII EKRYRSSIND KIIELKDLVM GTDAKMHKSG 360
  361 VLRKAIDYIK YLQQVNHKLR QENMVLKLAN QKNKLLKGID LGSLVDSDVD LKIDDFNQNV 420
  421 LLMSPPASDS GSQAGFSPYS IDSEPGSPLL DDAKVKDEPD SPPVALGMVD RSRILLCVLT 480
  481 FLGLSFNPLT SLLQWGGAHN PDQHPYSGSG RNVLSLESGS GGWFDWMMPT LLLWLLNGVI 540
  541 VLSVFVKLLV HGEPVIRPHS RSSVTFWRHR KQADLDLAKG DFAAAAANLQ TCLSVLGRAL 600
  601 PTSRLDLACS LSWNVIRYSL QKLRLVRWLL KKVFQRWRAT PATAAGFEDE AKSSARDAAL 660
  661 AYHRLHQLHI TGKLPAGSAC SDVHMALCAV NLAECAEEKI PPSTLVEIHL TAAMGLKTRC 720
  721 GGKLGFLASY FLNRAQSLCG PEHSAVPDSL RWLCHPLGQK FFMERSWSIK SAAKDSLYCA 780
  781 QRNPADPIAQ VHQAFCKHLL ERAVEALVKP QAKKKAGDRE EESCEFSSAL EFLKLLHSFV 840
  841 DSVGFVASPF SSSSVLRSAL GPDVVCRWWT SAITVAISWL QGDDAAVRSH FTEVERVPKA 900
  901 LEVTESPLVK AVFYACRAMH ASLSGKADGQ QNSFCHCERA SGHLWSSLNV SGTTSDPSLN 960
  961 HVVQLLTCDL LLSLRTTLWQ KQASASQLLG ETYHASGTEL AGFQRDLGSL RRLAHSFRPA1020
 1021 YRKVFLHEAT VRLMAGASPT RTHQLLEHSL RRRTTQNTKH GEVDTWPGQR ERATAILLAC1080
 1081 RHLPLSFLSS PGQRAVLLAE AARTLEKVGD RRSCSDCQQM IVKLGGGTAI AAS

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein Overview: SRBP2_RAT

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: