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Protein Overview: Zasp52-PC

General Information:
Name(s) found: Zasp52-PC / FBpp0086449 [FlyBase]
Description(s) found:
Found 15 descriptions.
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  • The gene Z band alternatively spliced PDZ-motif protein 52 is referred to in FlyBase by the symbol Dmel\Zasp52 (CG30084, FBgn0083919). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:11650070..11704314. It has the cytological map location 52C4-52C7. There is experimental evidence that it has the molecular function</span>: protein binding. The biological processes in which it is involved are not known. 17 alleles are reported. The phenotypes of these alleles are annotated with: Z disc; myofibril; embryonic somatic muscle; embryonic/larval somatic muscle. It has 7 annotated transcripts and 7 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1082 amino acids

    Gene Ontology:
    Cellular Component: Z disc [IDA]
    muscle tendon junction [IDA]
    Biological Process: NONE FOUND
    Molecular Function: zinc ion binding [IEA]
    protein binding [IPI]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAQPQLLQIK LSRFDAQPWG FRLQGGTDFA QPLLVQKVNA GSLSEQAGLQ PGDAVVKIND  60
   61 VDVFNLRHKD AQDIVVRSGN NFVITVQRGG STWRPHVTPT GNVPQPNSPY LQTVTKTSLA 120
  121 HKQQDSQHIG CGYNNAARPF SNGGDGGVKS IVNKQYNTPV GIYSDESIAE TLSAQAEVLA 180
  181 GGVLGVNFKK NEKEYQGDRS EVLKFLREEE TGQSTPAFGN SHYEHDAPQQ LQQPQQQYNQ 240
  241 HQQHYHQQQQ QQQSSTTRHV SAPVNSPKPP STGGLPTGQN ICTECERLIT GVFVRIKDKN 300
  301 LHVECFKCAT CGTSLKNQGY YNFNNKLYCD IHAKQAAINN PPTGTEGYVP VPIKPNTKLS 360
  361 ASTISSALNS HGYGGHSNGY SNGNSTPAPA PPESESSQEL PLPPPPSPTQ LLQYEAEQQV 420
  421 LPEPHMSTIQ QPQQQQKLEH TRTHSSLSSI SSGSSSSGVG GSGSGSGSGS GVGQSQQSYS 480
  481 STLSLDRFGS PLHSRQTSGS STSLEVALAA PGAGQGDNYT MTPPSPPPPP PPQAQSVTNY 540
  541 RLQAAQNEND MNTQNKSPNA YNQLLKEYSN KLQQQHHHNT TQHTTATTAP SLKHNNTAKP 600
  601 FAVAATSTPQ QHLPHQQHQQ QPLVAALTAT LANQLKFNPH QVASSQATAT VATVAPSAAT 660
  661 AATAAATPQA ATATDSPAAT ASSSDNMSAY VADEPSSIYG QISAESVALA PPPPQPPTAG 720
  721 GGDQPFEYVT LTGNVIRSVQ APGKGACPSY KVNQGYARPF GAAAPKSPVS YPPQQQQQSP 780
  781 RPAPGGQNPY ATLPRSNVGQ QGRNVRYQQQ QQQQQQYNNQ QKQQYRNSYP MGSNYSTPSQ 840
  841 SPYITSNTNN YSSSNSYNNN NYSNYNNNNV YRGAGGKSAG AFGATSAPKR GRGILNKAAG 900
  901 PGVRIPLCNS CNVQIRGPFI TALGRIWCPD HFICVNGNCR RPLQDIGFVE EKGDLYCEYC 960
  961 FEKYLAPTCS KCAGKIKGDC LNAIGKHFHP ECFTCGQCGK IFGNRPFFLE DGNAYCEADW1020
 1021 NELFTTKCFA CGFPVEAGDR WVEALNHNYH SQCFNCTFCK QNLEGQSFYN KGGRPFCKNH1080
 1081 AR

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..93] PSI-BLAST 20.522879 Solution structure of PDZ domain of mouse Alpha-actinin-2 associated LIM protein
    2 View Details [94..216] deduced N/A No confident structure predictions are available.
    3 View Details [217..520] FFAS03 3.76 No description for 2dfyX was found.
    4 View Details [521..664] deduced N/A No confident structure predictions are available.
    5 View Details [665..808] deduced N/A No confident structure predictions are available.
    6 View Details [809..900] PSI-BLAST 6.0 Transcription factor IIIA, TFIIIA
    7 View Details [901..1082] PSI-BLAST 34.221849 No description for 2i13A was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • structural constituent of muscle
    		•  3.94885944537237 bayes_pls_golite062009
  • actin binding
    		•  3.71885072001885 bayes_pls_golite062009
  • actinin binding
    		•  3.61513078757793 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  3.60106431937699 bayes_pls_golite062009
  • binding
    		•  3.2595117613307 bayes_pls_golite062009
  • protein binding
    		•  2.35875654816667 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.16834620509051 bayes_pls_golite062009
  • actin filament binding
    		•  1.91421788587359 bayes_pls_golite062009
  • myosin binding
    		•  1.34447751574529 bayes_pls_golite062009
  • alpha-actinin binding
    		•  0.81785989473612 bayes_pls_golite062009
  • transporter activity
    		•  0.782216866213126 bayes_pls_golite062009
  • structural molecule activity
    		•  0.745651480925433 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.699604120098573 bayes_pls_golite062009
  • PDZ domain binding
    		•  0.53069705861477 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.434921764966531 bayes_pls_golite062009
  • protein domain specific binding
    		•  0.30840185305841 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.250590541549843 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.211809989510755 bayes_pls_golite062009
  • signal transducer activity
    		•  0.211809989510755 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  0.182094987832726 bayes_pls_golite062009
  • transcription coactivator activity
    		•  0.171693460058476 bayes_pls_golite062009
  • transcription activator activity
    		•  0.0433431329070377 bayes_pls_golite062009
  • transcription factor binding
    		•  0.0283953080227368 bayes_pls_golite062009
  • receptor binding
    		•  0.00333430733556384 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6
    Term Confidence Notes
  • transcription regulator activity
    		•  4.70988788192472 bayes_pls_golite062009
  • DNA binding
    		•  4.56219307357342 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.28215395396923 bayes_pls_golite062009
  • transcription factor activity
    		•  3.50954949535763 bayes_pls_golite062009
  • binding
    		•  3.10743787485868 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.31369346002275 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  2.22104591928521 bayes_pls_golite062009
  • transcription activator activity
    		•  2.19952417915035 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.64349785387632 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  1.42975942698743 bayes_pls_golite062009
  • transcription factor binding
    		•  1.39608963544799 bayes_pls_golite062009
  • chromatin binding
    		•  1.37132088004982 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  1.0497955246512 bayes_pls_golite062009
  • protein binding
    		•  1.00484935878505 bayes_pls_golite062009
  • transcription coactivator activity
    		•  0.912796194488319 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.77874411480713 bayes_pls_golite062009
  • tubulin binding
    		•  0.744315484113484 bayes_pls_golite062009
  • microtubule binding
    		•  0.576452165256057 bayes_pls_golite062009
  • signal transducer activity
    		•  0.274401804698955 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.274401804698955 bayes_pls_golite062009
  • catalytic activity
    		•  0.245893663605433 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.240825841910931 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.10558148421807 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  0.0129353639725593 bayes_pls_golite062009
    7 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle