Protein Overview: SORT_RAT

General Information:
Name(s) found:	SORT_RAT [Swiss-Prot]
Description(s) found: SHOW ONLY BEST	gi\|84028264\|sp\|O54861.3\|SORT_RAT RecName: Full=Sortilin; AltName: Full=Neurotensin receptor 3; Short=NTR3; AltName: Full=Glycoprotein 110; Short=Gp110; Flags: Precursor [NCBI NR] gi\|209954677\|ref\|NP_113955.1\| sortilin 1 [Rattus norvegicus] [NCBI NR] gi\|109467411\|ref\|XP_001070486.1\| PREDICTED: similar to sortilin 1 isoform 2 [Rattus norvegicus] [NCBI NR] gi\|109465377\|ref\|XP_001076150.1\| PREDICTED: similar to sortilin 1 isoform 1 [Rattus norvegicus] [NCBI NR] Sortilin OS=Rattus norvegicus GN=Sort1 PE=1 SV=3 [Swiss-Prot] Tax_Id=10116 Sortilin precursor [EBI-IPI_rat_3.17_05-10-2006_con_reversed.fasta] Sortilin precursor (Neurotensin receptor 3) (NTR3) (Glycoprotein 110) (Gp110) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] PREDICTED: similar to sortilin 1 isoform 2 [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] PREDICTED: similar to sortilin 1 isoform 1 [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] sortilin 1 [Rattus norvegicus] [NCBI-RefSeq_human-rat_na_04-07-2009_con_reversed.fasta] Tax_Id=10116 Gene_Symbol=Sort1 Sortilin [rat-ipi-250309-contam.fasta] sortilin precursor [Rattus norvegicus] [NCBI-RefSeq_Human_na_04-23-2010_reversed.fasta] Sortilin OS=Rattus norvegicus GN=Sort1 [011711_HMR.fasta] Isoform of O54861, Sortilin OS=Rattus norvegicus GN=Sort1 PE=1 SV=2 [RAT.fasta.20160308]
Organism:	Rattus norvegicus
Length:	825 amino acids
Gene Ontology:
Cellular Component:	Golgi cisterna membrane [IEA] trans-Golgi network transport vesicle [UNKNOWN] microsome [UNKNOWN][IDA] endoplasmic reticulum [IEA] Golgi apparatus [UNKNOWN][IEA] neuronal cell body [IDA] lysosomal membrane [IEA] plasma membrane [UNKNOWN][IDA] cell surface [UNKNOWN] endoplasmic reticulum membrane [IEA] nucleus [IEA] dendrite [IDA] early endosome [UNKNOWN] nuclear membrane [IEA] endosome [IEA] perinuclear region of cytoplasm [UNKNOWN] coated pit [UNKNOWN] intracellular membrane-bounded organelle [IDA] integral to membrane [UNKNOWN][IDA][IEA] endosome membrane [IEA] cytoplasmic membrane-bounded vesicle [UNKNOWN] clathrin-coated vesicle [UNKNOWN]
Biological Process:	G-protein coupled receptor protein signaling pathway [UNKNOWN] multicellular organismal development [IEA] endosome to lysosome transport [UNKNOWN] glucose import [UNKNOWN] plasma membrane to endosome transport [UNKNOWN] intracellular protein transport [NAS] endocytosis [UNKNOWN][IEA] transport [IEA] induction of apoptosis by extracellular signals [UNKNOWN] Golgi to endosome transport [UNKNOWN] nerve growth factor receptor signaling pathway [UNKNOWN] negative regulation of lipoprotein lipase activity [UNKNOWN] neuropeptide signaling pathway [UNKNOWN] response to insulin stimulus [UNKNOWN] vesicle organization [UNKNOWN] ossification [IEA] negative regulation of apoptosis [UNKNOWN] endosome transport via multivesicular body sorting pathway [UNKNOWN] regulation of gene expression [UNKNOWN] cell differentiation [IEA] myotube differentiation [UNKNOWN]
Molecular Function:	protein binding [UNKNOWN] neurotensin receptor activity, G-protein coupled [TAS] receptor activity [IEA] nerve growth factor receptor activity [UNKNOWN] enzyme binding [UNKNOWN] neurotensin receptor activity, non-G-protein coupled [UNKNOWN] nerve growth factor binding [UNKNOWN]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MERPRGAADG LLRWPLGLLL LLQLLPPAAV GQDRLDAPPP PAPPLLRWAG PVGVSWGLRA  60
   61 AAPGGPVPRA GRWRRGAPAE DQDCGRLPDF IAKLTNNTHQ HVFDDLSGSV SLSWVGDSTG 120
  121 VILVLTTFQV PLVIVSFGQS KLYRSEDYGK NFKDITNLIN NTFIRTEFGM AIGPENSGKV 180
  181 ILTAEVSGGS RGGRVFRSSD FAKNFVQTDL PFHPLTQMMY SPQNSDYLLA LSTENGLWVS 240
  241 KNFGEKWEEI HKAVCLAKWG PNNIIFFTTH VNGSCKADLG ALELWRTSDL GKTFKTIGVK 300
  301 IYSFGLGGRF LFASVMADKD TTRRIHVSTD QGDTWSMAQL PSVGQEQFYS ILAANDDMVF 360
  361 MHVDEPGDTG FGTIFTSDDR GIVYSKSLDR HLYTTTGGET DFTNVTSLRG VYITSTLSED 420
  421 NSIQSMITFD QGGRWEHLQK PENSKCDATA KNKNECSLHI HASYSISQKL NVPMAPLSEP 480
  481 NAVGIVIAHG SVGDAISVMV PDVYISDDGG YSWAKMLEGP HYYTILDSGG IIVAIEHSNR 540
  541 PINVIKFSTD EGQCWQSYVF SQEPVYFTGL ASEPGARSMN ISIWGFTESF LTRQWVSYTI 600
  601 DFKDILERNC EENDYTTWLA HSTDPGDYKD GCILGYKEQF LRLRKSSVCQ NGRDYVVAKQ 660
  661 PSICPCSLED FLCDFGYFRP ENASECVEQP ELKGHELEFC LYGKEEHLTT NGYRKIPGDR 720
  721 CQGGMNPARE VKDLKKKCTS NFLNPKKQNS KSSSVPIILA IVGLMLVTVV AGVLIVKKYV 780
  781 CGGRFLVHRY SVLQQHAEAD GVEALDTASH AKSGYHDDSD EDLLE

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein Overview: SORT_RAT

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: