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Protein Overview: Eph-PB

General Information:
Name(s) found: Eph-PB / FBpp0088152 [FlyBase]
Description(s) found:
Found 17 descriptions.
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  • The gene Eph receptor tyrosine kinase is referred to in FlyBase by the symbol Dmel\Eph (CG1511, FBgn0025936). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 4:631312..641552. It has the cytological map location 102D1. Based on sequence similarity, it is predicted to have molecular function</span>: ephrin receptor activity; transmembrane receptor protein tyrosine kinase activity. There is experimental evidence that it is involved in the biological process</span>: mushroom body development. 12 alleles are reported. The phenotypes of these alleles are annotated with: medulla neuropil; commissure; lobula plate cortex; medulla cortex; longitudinal connective; mushroom body medial lobe; mushroom body vertical lobe; larval optic lobe; embryonic neuron. It has 6 annotated transcripts and 6 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1047 amino acids

    Gene Ontology:
    Cellular Component: integral to plasma membrane [IEA]
    plasma membrane [ISS]
    Biological Process: mushroom body development [IMP]
    signal transduction [ISS]
    axonogenesis [NAS]
    transmembrane receptor protein tyrosine kinase signaling pathway [IEA]
    protein amino acid phosphorylation [IEA][ISS][NAS]
    Molecular Function: ATP binding [IEA]
    protein tyrosine kinase activity [NAS]
    protein binding [IEA]
    transmembrane receptor protein tyrosine kinase activity [ISS][NAS]
    ephrin receptor activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTKSALKSAF YKNQAPISEQ NRSQIVSRMS LLRTILLIII SIHFKLAHAD QVVLLDTTRE  60
   61 ATLEWTRYPY GPQAQTPGWV EESFTDFVKG INWRSYVVCD VAYHNVNNWL WSPFIDRGSA 120
  121 NRLYIEIQFT IRDCSLFPGN ALSCKETFSL LFYEFDAATR EPPPWQTDSY RLIARIAAGE 180
  181 GRFNQNSDVD INTEVKSIAV NKKGVYFAFR DQGACISVLA VKVYYITCPA VTENFAHFNE 240
  241 TPTGREITII EKQNGTCVDN AEPYETPTYL CKGDGKWTIL TGGCRCKAGY EPNYTNKTCT 300
  301 ECPLGTFKSP EVTKCTPCPP NSNASKTGSP FCKCASGFYR HPNDGRHMPC YSPPAAPTNL 360
  361 TLLFVDQTSA IISWSAPAKN ESFSSETNSK IYHSDIVYKI KCNICSPNVV YNPSTDTFNE 420
  421 TKITLTNLEP VTTYTVQIHA INSVSHINEF KRHSNESSLV AVSDIVFSNT SLLNIPLDLN 480
  481 EVKTGQAEIV FTTESVLLST VFNLRILAIT NKDADLEWDK PVQSDFPLEF YEVRWFPKVE 540
  541 LDAINKSALN TKETKAHIVG LLENTEYGFQ VRCKTNNGFG SYSNMIYAQT LQSVGSVYDD 600
  601 SVQIRFIAGA IVTGVLFLVI FIIATVYFMR SKHQDDLDKK STNHLPLPLD YASNEVTTPL 660
  661 FGNSRSYVDP HTYEDPNQAI REFAREIDAN YITIEAIIGG GEFGDVCRGR LKIPPNFVQD 720
  721 IDVAIKTLKP GSSEKARCDF LTEASIMGQF DHPNVIYLQG VVTRSNPVMI ITEYMENGSL 780
  781 DTFLRVNDGK FQTLQLIVML RGIASGMSYL SDMNYVHRDL AARNVLVNAQ LICKIADFGL 840
  841 SREIENASDA YTTRGGKIPV RWTAPEAIAF RKFTSASDVW SYGVVLWEVM SYGERPYWNW 900
  901 SNQDVIKSIE KGYRLPAPMD CPEALYQLML DCWQKQRTHR PTFASIVSTL DNLARQPQSL 960
  961 LTTRPSPESD GNHILDGQRG QNIFISTDLW LEHIKMSRYC HHFKEANLIN AQQISRLTAQ1020
 1021 QLSDMGITLV GHQKKILHQA RQLDTII

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..217] PSI-BLAST 82.69897 Ligand-binding domain of the ephb2 receptor tyrosine kinase
    2 View Details [218..596] PSI-BLAST 17.522879 Receptor protein-tyrosine kinase Erbb-3 extracellular domain; Receptor protein-tyrosine kinase Erbb-3 Cys-rich domains
    3 View Details [597..669] PSI-BLAST 5.09691 No description for 2v5yA was found.
    4 View Details [670..966] PSI-BLAST 73.045757 No description for 2helA was found.
    5 View Details [967..1047] PSI-BLAST 80.69897 No description for 2qoqA was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • integrin binding
    		•  3.61193098087012 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  2.80879825615822 bayes_pls_golite062009
  • receptor activity
    		•  2.77268648576901 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine kinase activity
    		•  2.47762337031838 bayes_pls_golite062009
  • binding
    		•  2.31774167130542 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  2.23073603832866 bayes_pls_golite062009
  • phosphatidylserine binding
    		•  2.22270974208755 bayes_pls_golite062009
  • molecular transducer activity
    		•  2.03595043486636 bayes_pls_golite062009
  • signal transducer activity
    		•  2.03595043486636 bayes_pls_golite062009
  • protein binding
    		•  1.90867517664953 bayes_pls_golite062009
  • fucose binding
    		•  1.72607684089801 bayes_pls_golite062009
  • protein kinase activity
    		•  1.70755634087208 bayes_pls_golite062009
  • monosaccharide binding
    		•  1.62596107035359 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.39122779055629 bayes_pls_golite062009
  • kinase activity
    		•  1.31546222648513 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.28997154411534 bayes_pls_golite062009
  • carbohydrate binding
    		•  1.26743933952271 bayes_pls_golite062009
  • vascular endothelial growth factor receptor activity
    		•  1.21634643105777 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  1.18833031215069 bayes_pls_golite062009
  • sugar binding
    		•  1.1562287794497 bayes_pls_golite062009
  • glycoprotein binding
    		•  0.68697655195721 bayes_pls_golite062009
  • protein complex binding
    		•  0.56054373949313 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.533285414042183 bayes_pls_golite062009
  • transferase activity
    		•  0.530643564656921 bayes_pls_golite062009
  • receptor binding
    		•  0.365344483970243 bayes_pls_golite062009
  • DNA binding
    		•  0.324772578014229 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  0.24891369301653 bayes_pls_golite062009
  • ubiquitin-protein ligase activity
    		•  0.16022291279782 bayes_pls_golite062009
  • phosphatidylethanolamine binding
    		•  0.121022714964449 bayes_pls_golite062009
    2
    Term Confidence Notes
  • receptor activity
    		•  3.83269261081332 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  3.75945815830294 bayes_pls_golite062009
  • G-protein coupled receptor activity
    		•  3.09281229196379 bayes_pls_golite062009
  • molecular transducer activity
    		•  2.99319600166105 bayes_pls_golite062009
  • signal transducer activity
    		•  2.99319600166105 bayes_pls_golite062009
  • insulin-like growth factor I binding
    		•  2.97927266804248 bayes_pls_golite062009
  • glycosaminoglycan binding
    		•  1.94753631697974 bayes_pls_golite062009
  • binding
    		•  1.87302803330255 bayes_pls_golite062009
  • polysaccharide binding
    		•  1.72554005663659 bayes_pls_golite062009
  • protein binding
    		•  1.69661396118522 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  1.50579173120225 bayes_pls_golite062009
  • protein kinase activity
    		•  1.43632437878638 bayes_pls_golite062009
  • integrin binding
    		•  1.40983775289543 bayes_pls_golite062009
  • insulin-like growth factor II binding
    		•  1.39804733127147 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine kinase activity
    		•  1.36671598599873 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.16530645523007 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.12585418084562 bayes_pls_golite062009
  • kinase activity
    		•  1.11577341189523 bayes_pls_golite062009
  • growth factor binding
    		•  1.1095340886971 bayes_pls_golite062009
  • insulin-like growth factor receptor activity
    		•  1.05533763659606 bayes_pls_golite062009
  • actin filament binding
    		•  0.855558247588515 bayes_pls_golite062009
  • heparin binding
    		•  0.596331166056362 bayes_pls_golite062009
  • transferase activity
    		•  0.435331931559158 bayes_pls_golite062009
  • epidermal growth factor receptor binding
    		•  0.430075899423884 bayes_pls_golite062009
  • protein-hormone receptor activity
    		•  0.42902267001067 bayes_pls_golite062009
  • glycoprotein binding
    		•  0.41080910982871 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.370391722473665 bayes_pls_golite062009
  • receptor binding
    		•  0.319201203357304 bayes_pls_golite062009
  • phosphatase activator activity
    		•  0.234175951765568 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  0.231213253402712 bayes_pls_golite062009
  • pattern binding
    		•  0.195655028782749 bayes_pls_golite062009
  • enzyme activator activity
    		•  0.126307392530805 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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