Protein Overview: LX12L_RAT

General Information:
Name(s) found:	LX12L_RAT [Swiss-Prot]
Description(s) found: SHOW ONLY BEST	pir\|\|S30051 arachidonate 12-lipoxygenase (EC 1.13.11.31) - rat [NCBI NR] gi\|400195\|sp\|Q02759.2\|LX12L_RAT RecName: Full=Arachidonate 12-lipoxygenase, leukocyte-type; Short=12-LOX [NCBI NR] gi\|205213\|gb\|AAA41532.1\| 12-lipoxygenase [NCBI NR] Arachidonate 12-lipoxygenase, leukocyte-type OS=Rattus norvegicus GN=Alox12l PE=2 SV=2 [Swiss-Prot] Arachidonate 12-lipoxygenase (12-LOX)gi\|423620\|pir\|\|S30051 arachidonate 12-lipoxygenase (EC 1.13.11.31) - ratgi\|205213\|gb\|AAA41532.1\| 12-lipoxygenase [nrdb_11152004_Chlamydomonas] (NM_031010) arachidonate 12-lipoxygenase [Rattus norvegicus] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta] Arachidonate 12-lipoxygenase, leukocyte-type (12-LOX) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] 12-lipoxygenase [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Tax_Id=10116 Gene_Symbol=Alox15 Arachidonate 12-lipoxygenase, leukocyte-type [rat-ipi-250309-contam.fasta] Arachidonate 12-lipoxygenase, leukocyte-type OS=Rattus norvegicus GN=Alox12l [011711_HMR.fasta]
Organism:	Rattus norvegicus
Length:	663 amino acids
Gene Ontology:
Cellular Component:	cytoplasm [IEA] sarcolemma [ISS] cytosol [IDA]
Biological Process:	bone mineralization [UNKNOWN][IEA] positive regulation of cell proliferation [ISS] icosanoid biosynthetic process [NAS] positive regulation of cell growth [ISS] leukotriene biosynthetic process [IEA] regulation of membrane potential [TAS] anti-apoptosis [ISS] fatty acid oxidation [ISS] ossification [UNKNOWN] lipoxygenase pathway [IDA] negative regulation of cell volume [TAS] oxidation reduction [IEA] arachidonic acid metabolic process [IDA][NAS]
Molecular Function:	iron ion binding [IEA] oxidoreductase activity [IEA] metal ion binding [IEA] arachidonate 12-lipoxygenase activity [IDA] potassium channel inhibitor activity [TAS] arachidonate 15-lipoxygenase activity [IDA] lipoxygenase activity [IEA] hepoxilin-epoxide hydrolase activity [IDA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGVYRIRVST GDSKYAGSNN EVYLWLVGQH GEASLGKLLR PCRDSEAEFK VDVSEYLGPL  60
   61 LFVRVQKWHY LTDDAWFCNW ISVKGPGDQG SEYMFPCYRW VQGRSILSLP EGTGCTVVED 120
  121 SQGLFRKHRE EELEERRSLY RWGNWKDGSI LNVAAASISD LPVDQRFRED KRIEFEASQV 180
  181 IGVMDTVVNF PINTVTCWKS LDDFNCVFKS GHTKMAERVR NSWKEDAFFG YQFLNGANPM 240
  241 VLKRSTCLPA RLVFPPGMEK LQAQLNKELQ KGTLFEADFF LLDGIKANVI LCSQQYLAAP 300
  301 LVMLKLMPDG QLLPIAIQLE LPKTGSTPPP IFTPSDPPMD WLLAKCWVRS SDLQLHELQA 360
  361 HLLRGHLMAE LFAVATMRCL PSVHPVFKLL VPHLLYTMEI NVRARSDLIS ERGFFDKAMS 420
  421 TGGGGHLDLL KQAGAFLTYC SLCPPDDLAE RGLLDIETCF YAKDALRLWQ IMNRYVVGMF 480
  481 NLHYKTDKAV QDDYELQSWC REITDIGLQG AQDRGFPTSL QSRAQACYFI TMCIFTCTAQ 540
  541 HSSVHLGQLD WFYWVPNAPC TMRLPPPTTK EATMEKLMAT LPNPNQSTLQ INVVWLLGRR 600
  601 QAVMVPLGQH SEEHFPNPEA KAVLKKFREE LAALDKEIEI RNKSLDIPYE YLRPSMVENS 660
  661 VAI

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.94

Protein Overview: LX12L_RAT

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: