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Catalysis of the reaction: arachidonate + O2 = (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate. Catalysis of the incorporation of both atoms of oxygen from one molecule of O2 into the (reduced) substrate. Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and two oxygen atoms is incorporated into a donor. Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and molecular oxygen is incorporated into a donor.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: arachidonate 12-lipoxygenase activity
Acc: GO:0004052
Aspect: Molecular Function
Desc: Catalysis of the reaction: arachidonate + O2 = (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate.
Synonyms:
  • arachidonate:oxygen 12-oxidoreductase activity
  • delta12-lipoxygenase activity
  • C-12 lipoxygenase activity
  • LTA4 synthase activity
  • 12Delta-lipoxygenase activity
  • 12S-lipoxygenase activity
  • leukotriene A4 synthase
  • 12-lipoxygenase activity
Proteins in PDR annotated with:
   This term: 3 [Search]
   Term or descendants: 3 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0004052 - arachidonate 12-lipoxygenase activity (interactive image map)
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Created and Maintained by: Michael Riffle