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Protein Overview: HDAC1_PONPY

General Information:
Name(s) found: HDAC1_PONPY [Swiss-Prot]
Description(s) found:
Found 2 descriptions.
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  • Histone deacetylase 1 - Pongo pygmaeus (Orangutan) [Swiss-Prot]
    • Organism: Pongo pygmaeus
    Length: 482 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAQTQGTRRK VCYYYDGDVG NYYYGQGHPM KPHRIRMTHN LLLNYGLYRK MEIYRPHKAN  60
   61 AEEMTKYHSD DYIKFLRSIR PDNMSEYSKQ MQRFNVGEDC PVFDGLFEFC QLSTGGSVAS 120
  121 AVKLNKQQTD IAVNWAGGLH HAKKSEASGF CYVNDIVLAI LELLKYHQRV LYIDIDIHHG 180
  181 DGVEEAFYTT DRVMTVSFHK YGEYFPGTGD LRDIGAGKGK YYAVNYPLRD GIDDESYEAI 240
  241 FKPVMSKVME MFQPSAVVLQ CGSDSLSGDR LGCFNLTIKG HAKCVEFVKS FNLPMLMLGG 300
  301 GGYTIRNVAR CWTYETAVAL DTEIPNELPY NDYFEYFGPD FKLHISPSNM TNQNTNEYLE 360
  361 KIKQRLFENL RMLPHAPGVQ MQAIPEDAIP EESGDEDEDD PDKRISICSS DKRIACEEEF 420
  421 SDSEEEGEGG RKNSSNFKKA KRVKTEDEKE KDPEEKKEVT EEEKTKEEKP EAKGVKEEVK 480
  481 LA

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..379] PSI-BLAST 102.0 Crystal Structure of human HDAC8 complexed with Trichostatin A
    2 View Details [380..482] MSA 1.079985 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • protein deacetylase activity
    		•  12.8220438463909 bayes_pls_golite062009
  • histone deacetylase activity
    		•  12.6231784270509 bayes_pls_golite062009
  • deacetylase activity
    		•  11.5037545953213 bayes_pls_golite062009
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
    		•  9.39837596691907 bayes_pls_golite062009
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
    		•  5.91624581343504 bayes_pls_golite062009
  • histone deacetylase activity (H3-K16 specific)
    		•  4.36879207064621 bayes_pls_golite062009
  • histone methyltransferase activity (H3-K27 specific)
    		•  3.8227021325477 bayes_pls_golite062009
  • agmatinase activity
    		•  3.73238467801147 bayes_pls_golite062009
  • histone deacetylase activity (H3-K9 specific)
    		•  3.65015413158247 bayes_pls_golite062009
  • histone deacetylase activity (H3-K14 specific)
    		•  3.59362549089403 bayes_pls_golite062009
  • transcription repressor activity
    		•  3.49362347258099 bayes_pls_golite062009
  • NAD-dependent histone deacetylase activity
    		•  3.35999169984456 bayes_pls_golite062009
  • NAD-dependent protein deacetylase activity
    		•  3.35999169984456 bayes_pls_golite062009
  • transcription regulator activity
    		•  3.05701986980927 bayes_pls_golite062009
  • hydrolase activity
    		•  2.48411098726406 bayes_pls_golite062009
  • transcription factor binding
    		•  2.19991964087943 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.09632179671955 bayes_pls_golite062009
  • transcription corepressor activity
    		•  1.98907367314887 bayes_pls_golite062009
  • DNA binding
    		•  1.982290944939 bayes_pls_golite062009
  • binding
    		•  1.948738669065 bayes_pls_golite062009
  • protein binding
    		•  1.77599011146146 bayes_pls_golite062009
  • catalytic activity
    		•  1.68836803454021 bayes_pls_golite062009
  • histone methyltransferase activity (H3-K9 specific)
    		•  1.48241147541212 bayes_pls_golite062009
  • specific transcriptional repressor activity
    		•  1.37118634909958 bayes_pls_golite062009
  • arginase activity
    		•  1.34373529002692 bayes_pls_golite062009
  • transcription factor activity
    		•  1.24596588472933 bayes_pls_golite062009
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
    		•  1.01223037319069 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.84972377395539 bayes_pls_golite062009
  • histone methyltransferase activity
    		•  0.396822865624511 bayes_pls_golite062009
  • transferase activity
    		•  0.323230424038105 bayes_pls_golite062009
  • chromatin binding
    		•  0.104097933861351 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle