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Protein Overview: EG10062

General Information:
Name(s) found: arcB / EG10062 [EcoGene]
Description(s) found:
Found 9 descriptions.
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  • aerobic respiration control sensor histidine protein kinase, cognate to two-component response regulators ArcA and RssB / Aerobic respiration control sensor histidine protein kinase; phosphorylates response regulator proteins ArcA and RssB [EcoGene]
    • Organism: Escherichia coli K-12
    Length: 778 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKQIRLLAQY YVDLMMKLGL VRFSMLLALA LVVLAIVVQM AVTMVLHGQV ESIDVIRSIF  60
   61 FGLLITPWAV YFLSVVVEQL EESRQRLSRL VQKLEEMRER DLSLNVQLKD NIAQLNQEIA 120
  121 VREKAEAELQ ETFGQLKIEI KEREETQIQL EQQSSFLRSF LDASPDLVFY RNEDKEFSGC 180
  181 NRAMELLTGK SEKQLVHLKP ADVYSPEAAA KVIETDEKVF RHNVSLTYEQ WLDYPDGRKA 240
  241 CFEIRKVPYY DRVGKRHGLM GFGRDITERK RYQDALERAS RDKTTFISTI SHELRTPLNG 300
  301 IVGLSRILLD TELTAEQEKY LKTIHVSAVT LGNIFNDIID MDKMERRKVQ LDNQPVDFTS 360
  361 FLADLENLSA LQAQQKGLRF NLEPTLPLPH QVITDGTRLR QILWNLISNA VKFTQQGQVT 420
  421 VRVRYDEGDM LHFEVEDSGI GIPQDELDKI FAMYYQVKDS HGGKPATGTG IGLAVSRRLA 480
  481 KNMGGDITVT SEQGKGSTFT LTIHAPSVAE EVDDAFDEDD MPLPALNVLL VEDIELNVIV 540
  541 ARSVLEKLGN SVDVAMTGKA ALEMFKPGEY DLVLLDIQLP DMTGLDISRE LTKRYPREDL 600
  601 PPLVALTANV LKDKQEYLNA GMDDVLSKPL SVPALTAMIK KFWDTQDDEE STVTTEENSK 660
  661 SEALLDIPML EQYLELVGPK LITDGLAVFE KMMPGYVSVL ESNLTAQDKK GIVEEGHKIK 720
  721 GAAGSVGLRH LQQLGQQIQS PDLPAWEDNV GEWIEEMKEE WRHDVEVLKA WVAKATKK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..123] PSI-BLAST 11.0 No description for 2gj3A was found.
    2 View Details [124..265] PSI-BLAST 6.09691 Crystal Structure of the heme PAS sensor domain of Ec DOS (ferric form)
    3 View Details [266..517] PSI-BLAST 42.221849 Structure of the entire cytoplasmic portion of a sensor histidine kinase protein
    4 View Details [518..778] PSI-BLAST 27.0 Response regulator PleD in complex with c-diGMP

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • ion transmembrane transporter activity
    		•  1.94020112661684 bayes_pls_golite062009
  • binding
    		•  1.79230776794479 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  1.70629448457771 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  1.55042643398568 bayes_pls_golite062009
  • two-component response regulator activity
    		•  1.45691562840107 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  1.31850321187865 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.13913685347546 bayes_pls_golite062009
  • protein binding
    		•  1.0133195984081 bayes_pls_golite062009
  • potassium channel activity
    		•  0.93265112299626 bayes_pls_golite062009
  • voltage-gated ion channel activity
    		•  0.92661046549451 bayes_pls_golite062009
  • voltage-gated cation channel activity
    		•  0.926512767264521 bayes_pls_golite062009
  • voltage-gated potassium channel activity
    		•  0.92204538811959 bayes_pls_golite062009
  • voltage-gated channel activity
    		•  0.91469735366704 bayes_pls_golite062009
  • ion channel activity
    		•  0.75430461252947 bayes_pls_golite062009
  • cation channel activity
    		•  0.73262554730695 bayes_pls_golite062009
  • DNA binding
    		•  0.73243452463464 bayes_pls_golite062009
  • gated channel activity
    		•  0.67217953143815 bayes_pls_golite062009
  • substrate-specific channel activity
    		•  0.650205954115699 bayes_pls_golite062009
  • channel activity
    		•  0.64202076714636 bayes_pls_golite062009
  • passive transmembrane transporter activity
    		•  0.64202076714636 bayes_pls_golite062009
  • two-component sensor activity
    		•  0.58151911764083 bayes_pls_golite062009
  • protein histidine kinase activity
    		•  0.56538125817883 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.5545839402512 bayes_pls_golite062009
  • phosphotransferase activity, nitrogenous group as acceptor
    		•  0.518111391350209 bayes_pls_golite062009
  • signal transducer activity
    		•  0.441034662376355 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.441034662376355 bayes_pls_golite062009
  • transcription factor activity
    		•  0.36759096137141 bayes_pls_golite062009
  • transporter activity
    		•  0.360938622392148 bayes_pls_golite062009
  • catalytic activity
    		•  0.285447488878019 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.217804199010847 bayes_pls_golite062009
    3 No functions predicted.
    4
    Term Confidence Notes
  • two-component response regulator activity
    		•  7.02872640261738 bayes_pls_golite062009
  • signal transducer activity
    		•  4.51666042720644 bayes_pls_golite062009
  • molecular transducer activity
    		•  4.51666042720644 bayes_pls_golite062009
  • transcription regulator activity
    		•  3.44888100104099 bayes_pls_golite062009
  • protein histidine kinase activity
    		•  2.35011582062573 bayes_pls_golite062009
  • two-component sensor activity
    		•  2.32303301074957 bayes_pls_golite062009
  • phosphotransferase activity, nitrogenous group as acceptor
    		•  2.28838869071567 bayes_pls_golite062009
  • binding
    		•  1.22427537074115 bayes_pls_golite062009
  • DNA binding
    		•  1.11037597107903 bayes_pls_golite062009
  • protein kinase activity
    		•  1.00737355751913 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.93151849951839 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.811771244977462 bayes_pls_golite062009
  • kinase activity
    		•  0.725824770559857 bayes_pls_golite062009
  • transcription factor activity
    		•  0.62886970109503 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.476057209677045 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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